Pyruvate dehydrogenase lipoamide kinase isozyme 1 information

PDK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2Q8F, 2Q8G, 2Q8H
Identifiers
Aliases	PDK1, entrez:5163, pyruvate dehydrogenase kinase 1
External IDs	OMIM: 602524 MGI: 1926119 HomoloGene: 134437 GeneCards: PDK1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	172,608,669 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	71,734,202 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; right ventricle; ; jejunal mucosa; ; thymus; ; endothelial cell; ; trabecular bone; ; tibia; ; human penis; ; oral cavity; ; bone marrow;
	Top expressed in
	iris; ; otic placode; ; saccule; ; atrium; ; atrioventricular valve; ; ciliary body; ; Paneth cell; ; stria vascularis; ; cumulus cell; ; intercostal muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; protein binding; ATP binding; pyruvate dehydrogenase (acetyl-transferring) kinase activity;
Cellular component	mitochondrial pyruvate dehydrogenase complex; mitochondrial matrix; nucleus; nucleolus; mitochondrion;
Biological process	intrinsic apoptotic signaling pathway in response to oxidative stress; phosphorylation; hypoxia-inducible factor-1alpha signaling pathway; regulation of acetyl-CoA biosynthetic process from pyruvate; regulation of glucose metabolic process; glucose metabolic process; cell population proliferation; protein phosphorylation; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	5163
	228026
	ENSG00000152256
	ENSMUSG00000006494
	Q15118
	Q8BFP9
	NM_001278549; NM_002610
	NM_172665; NM_001360002
	NP_001265478; NP_002601
	NP_766253; NP_001346931
	Wikidata
View/Edit Human	View/Edit Mouse

Pyruvate dehydrogenase lipoamide kinase isozyme 1, mitochondrial is an enzyme that in humans is encoded by the PDK1 gene.^[5]^[6] It codes for an isozyme of pyruvate dehydrogenase kinase (PDK).

Pyruvate dehydrogenase (PDH) is a part of a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000152256 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006494 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gudi R, Bowker-Kinley MM, Kedishvili NY, Zhao Y, Popov KM (Jan 1996). "Diversity of the pyruvate dehydrogenase kinase gene family in humans". J Biol Chem. 270 (48): 28989–94. doi:10.1074/jbc.270.48.28989. PMID 7499431.
^ ^a ^b "Entrez Gene: PDK1 pyruvate dehydrogenase kinase, isozyme 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000152256 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006494 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7499431-5] Gudi R, Bowker-Kinley MM, Kedishvili NY, Zhao Y, Popov KM (Jan 1996). "Diversity of the pyruvate dehydrogenase kinase gene family in humans". J Biol Chem. 270 (48): 28989–94. doi:10.1074/jbc.270.48.28989. PMID 7499431.

[entrez-6] "Entrez Gene: PDK1 pyruvate dehydrogenase kinase, isozyme 1".

Pyruvate dehydrogenase lipoamide kinase isozyme 1 information

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