UvrABC endonuclease information

UvrABC endonuclease
Identifiers
Aliases	uvrABC systemexcinuclease ABC
External IDs	GeneCards: [1]; OMA:- orthologs
Orthologs
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	n; a
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	Wikidata
View/Edit Human

UvrABC endonuclease is a multienzyme complex in bacteria involved in DNA repair by nucleotide excision repair, and it is, therefore, sometimes called an excinuclease. This UvrABC repair process, sometimes called the short-patch process, involves the removal of twelve nucleotides where a genetic mutation has occurred followed by a DNA polymerase, replacing these aberrant nucleotides with the correct nucleotides and completing the DNA repair. The subunits for this enzyme are encoded in the uvrA, uvrB, and uvrC genes. This enzyme complex is able to repair many different types of damage, including cyclobutyl dimer formation.^[1]

^ Grossman L, Yeung AT (1990). "The UvrABC endonuclease system of Escherichia coli—a view from Baltimore". Mutat. Res. 236 (2–3): 213–21. doi:10.1016/0921-8777(90)90006-q. PMID 2144612.

[1] Grossman L, Yeung AT (1990). "The UvrABC endonuclease system of Escherichia coli—a view from Baltimore". Mutat. Res. 236 (2–3): 213–21. doi:10.1016/0921-8777(90)90006-q. PMID 2144612.

UvrABC endonuclease information

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