Biochemical process involving the production of fats
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In biochemistry, lipogenesis is the conversion of fatty acids and glycerol into fats, or a metabolic process through which acetyl-CoA is converted to triglyceride for storage in fat.[1] Lipogenesis encompasses both fatty acid and triglyceride synthesis, with the latter being the process by which fatty acids are esterified to glycerol before being packaged into very-low-density lipoprotein (VLDL). Fatty acids are produced in the cytoplasm of cells by repeatedly adding two-carbon units to acetyl-CoA. Triacylglycerol synthesis, on the other hand, occurs in the endoplasmic reticulum membrane of cells by bonding three fatty acid molecules to a glycerol molecule. Both processes take place mainly in liver and adipose tissue. Nevertheless, it also occurs to some extent in other tissues such as the gut and kidney.[2][3] A review on lipogenesis in the brain was published in 2008 by Lopez and Vidal-Puig.[4] After being packaged into VLDL in the liver, the resulting lipoprotein is then secreted directly into the blood for delivery to peripheral tissues.
^Kersten S (April 2001). "Mechanisms of nutritional and hormonal regulation of lipogenesis". EMBO Rep. 2 (4): 282–6. doi:10.1093/embo-reports/kve071. PMC 1083868. PMID 11306547.
^Hoffman, Simon; Alvares, Danielle; Adeli, Khosrow (2019). "Intestinal lipogenesis: how carbs turn on triglyceride production in the gut". Current Opinion in Clinical Nutrition and Metabolic Care. 22 (4): 284–288. doi:10.1097/MCO.0000000000000569. ISSN 1473-6519. PMID 31107259. S2CID 159039179.
^Figueroa-Juárez, Elizabeth; Noriega, Lilia G.; Pérez-Monter, Carlos; Alemán, Gabriela; Hernández-Pando, Rogelio; Correa-Rotter, Ricardo; Ramírez, Victoria; Tovar, Armando R.; Torre-Villalvazo, Iván; Tovar-Palacio, Claudia (2021-01-07). "The Role of the Unfolded Protein Response on Renal Lipogenesis in C57BL/6 Mice". Biomolecules. 11 (1): 73. doi:10.3390/biom11010073. ISSN 2218-273X. PMC 7825661. PMID 33430288.
^López, Miguel; Vidal-Puig, Antonio (2008). "Brain lipogenesis and regulation of energy metabolism". Current Opinion in Clinical Nutrition and Metabolic Care. 11 (4): 483–490. doi:10.1097/MCO.0b013e328302f3d8. ISSN 1363-1950. PMID 18542011. S2CID 40680910.
promote the absorption and storage of sugars, including lipogenesis. Insulin stimulates lipogenesis primarily by activating two enzymatic pathways. Pyruvate...
de novo lipogenesis occurs primarily in adipose tissue. But in conditions of obesity, insulin resistance, or type 2 diabetes de novo lipogenesis is reduced...
Lipogenesis inhibitor is a class of drug that works by inhibiting de novo lipogenesis—the generation of fatty acids in the body. These drugs target enzymes...
promoting fatty acid oxidation and inhibiting lipogenesis. Testosterone: stimulates de novo lipogenesis and fat accumulation which are then incorporated...
as carbohydrate insufficiency. Its activation in the liver inhibits lipogenesis, promotes fatty acid oxidation, switches off acetyl-CoA carboxylase,...
lactogen. Fetal insulin is responsible for increasing glucose uptake and lipogenesis during the stages leading up to birth. Fetal cells contain a higher amount...
triglyceride content, as well as the activation of downstream target genes of lipogenesis. Insulin resistance likewise improved in these mice as a result of the...
feeding in mice increases levels of anandamide in the liver and increases lipogenesis. Anandamide may be relevant to the development of obesity, at least in...
contributed to by futile cycles, such as the simultaneous occurrence of lipogenesis and lipolysis or glycolysis and gluconeogenesis. In a broader context...
of fatty acids in the production of triglycerides, a process called lipogenesis.: 634 Fatty acids are made by fatty acid synthases that polymerize and...
several roles in lipid metabolism: it performs cholesterol synthesis, lipogenesis, and the production of triglycerides, and a bulk of the body's lipoproteins...
modification has an inhibitory effect on these enzymes, thus inhibiting lipogenesis and promoting net gluconeogenesis. Insulin, on the other hand, decreases...
supply cytosolic NADPH to counteract oxidative damage or support de novo lipogenesis. Several deficiencies in the level of activity (not function) of glucose-6-phosphate...
into either glycogen, via glycogenesis, or fats (triglycerides), via lipogenesis; in the liver, glucose is converted into both. Glucose production and...
Zaidi N, Lupien L, Kuemmerle NB, Kinlaw WB, Swinnen JV, Smans K (2013). "Lipogenesis and lipolysis: The pathways exploited by the cancer cells to acquire...
The effects of cortisol on lipid metabolism are more complicated since lipogenesis is observed in patients with chronic, raised circulating glucocorticoid...
the liver, activation of the CB1 receptor is known to increase de novo lipogenesis. CB2 receptors are expressed on T cells of the immune system, on macrophages...
cholesterol synthesis zone III cells are more important for glycolysis, lipogenesis and cytochrome P-450-based drug detoxification. This specialization is...
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