Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Lipoic acid (LA), also known as α-lipoic acid, alpha-lipoic acid (ALA) and thioctic acid, is an organosulfur compound derived from caprylic acid (octanoic acid).[3] ALA is made in animals normally, and is essential for aerobic metabolism. It is also manufactured and is available as a dietary supplement in some countries where it is marketed as an antioxidant, and is available as a pharmaceutical drug in other countries. Lipoate is the conjugate base of lipoic acid, and the most prevalent form of LA under physiological conditions.[3]
Only the (R)-(+)-enantiomer (RLA) exists in nature and is essential for aerobic metabolism because RLA is an essential cofactor of many enzyme complexes.[3]
^"Lipoic Acid". Pubmed. NCBI. Retrieved October 18, 2018.
^Teichert, J; Hermann, R; Ruus, P; Preiss, R (November 2003). "Plasma kinetics, metabolism, and urinary excretion of alpha-lipoic acid following oral administration in healthy volunteers". The Journal of Clinical Pharmacology. 43 (11): 1257–67. doi:10.1177/0091270003258654. PMID 14551180. S2CID 30589232.
^ abc"Lipoic acid". Micronutrient Information Center, Linus Pauling Institute, Oregon State University, Corvallis. 1 January 2019. Retrieved 5 November 2019.
Lipoicacid (LA), also known as α-lipoicacid, alpha-lipoicacid (ALA) and thioctic acid, is an organosulfur compound derived from caprylic acid (octanoic...
asparagusic acid can substitute for lipoicacid in α-keto-acid oxidation systems such as the citric acid cycle. The (R)-(+)-enantiomer of α-lipoicacid is a...
malonyl-CoA from acetyl-CoA. The fatty acids, such as octanoyl-ACP (C8), which forms the starting substrate of lipoicacid biosynthesis, are formed via further...
pilocarpine, zinc supplementation, alterations in drug therapy, and alpha lipoicacid. The alterations in the sense of taste, usually a metallic taste, and...
Dihydrolipoic acid is an organic compound that is the reduced form of lipoicacid. This carboxylic acid features a pair of thiol groups, and therefore...
The citric acid cycle—also known as the Krebs cycle, Szent–Györgyi–Krebs cycle or the TCA cycle (tricarboxylic acid cycle)—is a series of biochemical reactions...
acids are steroid acids found predominantly in the bile of mammals and other vertebrates. Diverse bile acids are synthesized in the liver. Bile acids...
therefore comparable in effect to calorie restriction (CR). LipoicAcid (α-LipoicAcid, Alpha LipoicAcid, or ALA) has failed to extend lifespan in normal mice...
trivial name for 6,8-dithiooctanoic amide. It is the functional form of lipoicacid, i.e the carboxyl group is attached to protein via an amine with an amide...
mtFASII, which also forms the starting substrate of lipoicacid biosynthesis. Since lipoicacid is the cofactor of important mitochondrial enzyme complexes...
Dibenzothiophene, a component of crude oil Perfluorooctanesulfonic acid, a controversial surfactant Lipoicacid, an essential cofactor of four mitochondrial enzyme complexes...
There is some evidence that alpha-lipoicacid (ALA) may work as a milder chelator of tissue-bound copper. Alpha lipoicacid is also being researched for chelating...
peroxide consumption via glutaredoxin. Glutathionylation “protects” the lipoicacid of the E2 domain from undergoing oxidative damage, which helps spare...
are then sulfonated with sulfur trioxide to give the sulfonic acid. The sulfonic acid is subsequently neutralized with sodium hydroxide. The term "linear"...
use in pregnancy is unclear. It works by blocking the release of stomach acid. Omeprazole was patented in 1978, and approved for medical use in 1988. It...
Ellagic acid is a polyphenol found in numerous fruits and vegetables. It is the dilactone of hexahydroxydiphenic acid. The name comes from the French...
of studies found that injected (parenteral) administration of alpha lipoicacid (ALA) was found to reduce the various symptoms of peripheral diabetic...
Teichert J, Preiss R (November 1992). "HPLC-methods for determination of lipoicacid and its reduced form in human plasma". International Journal of Clinical...
Other chelating agents, such as 2,3-dimercaptopropanesulfonic acid (DMPS) and alpha lipoicacid (ALA), are used in conventional and alternative medicine....
It also increases the activity of MEF2, mainly MEF2C, in N2a cells. α-lipoicacid (LA) mainly causes N2a differentiation through phosphorylation of the...
is a coupling of a DV-acid ester and an alcohol. In the case of permethrin synthesis, the DV-acid cyclopropanecarboxylic acid, 3-(2,2-dichloroethenyl)-2...
identify any study comparing acupuncture with treatment as usual." Alpha lipoicacid (ALA) with benfotiamine is a proposed pathogenic treatment for painful...
Valproate (valproic acid, VPA, sodium valproate, and valproate semisodium forms) are medications primarily used to treat epilepsy and bipolar disorder...
February 2017, an article was published in Nature Medicine entitled "Alpha lipoicacid treatment prevents cystine urolithiasis in a mouse model of cystinuria"...
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