Chemical compound
Moperone Trade names Luvatren (discontinued) ATC code Legal status
BR : Class C1 (Other controlled substances)[1]
1-(4-fluorophenyl)-4-[4-hydroxy-4-(4-methylphenyl)piperidin-1-yl]butan-1-one
CAS Number PubChem CID DrugBank ChemSpider UNII KEGG CompTox Dashboard (EPA ) DTXSID6049062 ECHA InfoCard 100.012.625 Formula C 22 H 26 F N O 2 Molar mass 355.453 g·mol−1 3D model (JSmol)
CC1=CC=C(C=C1)C1(O)CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1
InChI=1S/C22H26FNO2/c1-17-4-8-19(9-5-17)22(26)12-15-24(16-13-22)14-2-3-21(25)18-6-10-20(23)11-7-18/h4-11,26H,2-3,12-16H2,1H3
Key:AGAHNABIDCTLHW-UHFFFAOYSA-N
Moperone (Luvatren , since discontinued) is a typical antipsychotic of the butyrophenone class[2] which is marketed in Japan for the treatment of schizophrenia. It is an antagonist for the D2 (Ki 0.7–1.9 nM), D3 (Ki 0.1–1 nM), and 5-HT2A (Ki 52 nM) receptors. It also has a high binding affinity for the sigma receptors.[3] [4]
^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16 .
^ Gross H, Kaltenbäck E (1969). "The clinical position of moperone among the butyrophenones". Nordisk Psykiatrisk Tidsskrift. Nordic Journal of Psychiatry . 23 (1): 4–9. doi:10.3109/08039486909132154. PMID 5354545.
^ Miyamoto S (2010). "Moperone". In Stolerman IP (ed.). Encyclopedia of Psychopharmacology . Berlin, Heidelberg: Springer. p. 798. doi:10.1007/978-3-540-68706-1_1838. ISBN 978-3-540-68706-1 . Retrieved 21 March 2022 .
^ Roth BL, Driscol J. "PDSP Ki Database". Psychoactive Drug Screening Program (PDSP) . University of North Carolina at Chapel Hill and the United States National Institute of Mental Health. Retrieved 21 March 2022 .
Last Update: 2023-08-16T08:07:23Z
Moperone (Luvatren, since discontinued) is a typical antipsychotic of the butyrophenone class which is marketed in Japan for the treatment of schizophrenia...
Word Count : 216
Last Update: 2024-02-21T02:08:44Z
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Last Update: 2024-03-25T20:48:25Z
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Last Update: 2023-12-03T13:12:20Z
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Last Update: 2024-05-14T06:10:24Z
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Last Update: 2024-05-16T00:48:48Z
Levomepromazine (methotrimeprazine) Levosulpiride Loxapine Mesoridazine Moperone Naranol Nemonapride Penfluridol Perathiepin Perazine Pericyazine (periciazine)...
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Last Update: 2024-05-08T15:18:49Z
Bromperidol Bromperidol decanoate Droperidol Haloperidol# Haloperidol decanoate Moperone Pipamperone Spiperone Timiperone Trifluperidol Diphenylbutylpiperidines:...
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Last Update: 2024-04-02T05:19:08Z
Bromperidol Bromperidol decanoate Droperidol Haloperidol# Haloperidol decanoate Moperone Pipamperone Spiperone Timiperone Trifluperidol Diphenylbutylpiperidines:...
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Last Update: 2024-05-19T06:42:59Z
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Last Update: 2024-05-20T10:26:11Z
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Last Update: 2024-03-30T16:28:09Z
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Last Update: 2024-01-25T15:38:39Z
Pipotiazine N05AD01 Haloperidol N05AD02 Trifluperidol N05AD03 Melperone N05AD04 Moperone N05AD05 Pipamperone N05AD06 Bromperidol N05AD07 Benperidol N05AD08 Droperidol...
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Last Update: 2024-04-26T23:03:45Z
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Last Update: 2023-08-11T20:57:39Z
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Last Update: 2024-04-19T17:28:13Z
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Last Update: 2024-04-27T11:23:32Z
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Last Update: 2024-03-28T19:23:24Z
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Last Update: 2024-04-23T21:43:59Z
Levomepromazine (methotrimeprazine) Levosulpiride Loxapine Mesoridazine Moperone Naranol Nemonapride Penfluridol Perathiepin Perazine Pericyazine (periciazine)...
Word Count : 6980
Last Update: 2024-04-13T05:38:56Z
Levomepromazine (methotrimeprazine) Levosulpiride Loxapine Mesoridazine Moperone Naranol Nemonapride Penfluridol Perathiepin Perazine Pericyazine (periciazine)...
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