Mitochondrial network (green) in two human cells (HeLa cells)
Mitochondrial fission is the process where mitochondria divide or segregate into two separate mitochondrial organelles. Mitochondrial fission is counteracted by the process of mitochondrial fusion, whereby two separate mitochondria can fuse together to form a large one.[1] Mitochondrial fusion in turn can result in elongated mitochondrial networks. Both mitochondrial fission and fusion are balanced in the cell, and mutations interfering with either processes are associated with a variety of diseases. Mitochondria can divide by prokaryotic binary fission and since they require mitochondrial DNA for their function, fission is coordinated with DNA replication.[2] Some of the proteins that are involved in mitochondrial fission have been identified and some of them are associated with mitochondrial diseases.[3] Mitochondrial fission has significant implications in stress response and apoptosis.[4]
^Lewis, Margaret (1915). "Mitochondria (and other cytoplasmic structures) in tissue cultures" (PDF). American Journal of Anatomy. 17 (3): 339–401. doi:10.1002/aja.1000170304.
^Lewis, S.; Uchiyama, L.; Nunnari, J. (15 July 2016). "ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells". Science. 353 (6296). doi:10.1126/science.aaf5549. PMC 5554545. PMID 27418514.
^Otera, Hidenori, and Katsuyoshi Mihara. "Discovery of the membrane receptor for mitochondrial fission GTPase Drp1." Small GTPases 2.3 (2011): 241-251.
^Chan, DC (2012). "Fusion and fission: interlinked processes critical for mitochondrial health". Annu. Rev. Genet. 46: 265–287. doi:10.1146/annurev-genet-110410-132529. PMID 22934639.
and 27 Related for: Mitochondrial fission information
Mitochondrialfission is the process where mitochondria divide or segregate into two separate mitochondrial organelles. Mitochondrialfission is counteracted...
Mitochondrialfission factor (Mff) is a protein that in humans is encoded by the MFF gene. Its primary role is in controlling the division of mitochondria...
balance of fission and fusion in a cell, it could significantly alter the mitochondrial network. For example, an increase in mitochondrialfission would create...
regulates inner mitochondrial membrane fusion, MFN1 is a mediator of mitochondrial fusion and DRP1 is responsible for mitochondrialfission. The human mitofusin-2...
Dynamin-1-like protein is a GTPase that regulates mitochondrialfission. In humans, dynamin-1-like protein, which is typically referred to as dynamin-related...
Human mitochondrial genetics is the study of the genetics of human mitochondrial DNA (the DNA contained in human mitochondria). The human mitochondrial genome...
PINK1 may also control mitochondria quality through mitochondrialfission. Through mitochondrialfission, a number of daughter mitochondria are created, often...
ability to fuse and divide (fission), forming constantly changing tubular networks in most eukaryotic cells. These mitochondrial dynamics, first observed...
assist in mitochondrial binary fission. It is a dynamic peripheral protein receptor found on the surface of the mitochondrial membrane. MID51 is a very similar...
mitochondrion, there may be random segregation of the chromosomes during mitochondrialfission to generate new mitochondria. This can give rise to a mitochondrion...
triggers mitochondrialfission, leads to a loss of mitochondrial membrane potential and causes host cell death. Fission is also linked to mitochondrial Bax/Bak...
non-profit chemistry organization MFF (gene), encodes the protein mitochondrialfission factor MFF SIM, SIM cards for machine use Manly Fast Ferry, ferry...
an increase in reactive oxygen species, mitochondrial swelling and fission, and an increase in mitochondrial turnover via autophagy. Sequence similarity...
mitochondrialfission and fusion, lipid concentration of the mitochondrial membranes, and the mitochondrial permeability transition. Mitochondrial disease...
induce rapid, non-canonical mitochondrialfission by causing the mitochondrial matrix to fragment while the outer mitochondrial membrane can remain intact...
transport along microtubule regulation of mitochondrialfission negative regulation of mitochondrialfission axonal transport regulation of cellular response...
Lipton SA (August 2010). "S-nitrosylation of Drp1 links excessive mitochondrialfission to neuronal injury in neurodegeneration". Mitochondrion. 10 (5):...
2010). "Misfolding of short-chain acyl-CoA dehydrogenase leads to mitochondrialfission and oxidative stress". Molecular Genetics and Metabolism. 100 (2):...
help modulate mitochondrial fusion and fission. In healthy conditions, VPS35 helps regulate mitochondrial fusion by removing mitochondrial E3 ubiquitin...
in the relocation of RalA to the inner mitochondrial membrane, where RalA helps carry out mitochondrialfission; whereas phosphorylation of Serine 198...
Schizosaccharomyces pombe, also called "fission yeast", is a species of yeast used in traditional brewing and as a model organism in molecular and cell...
protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. LRRK2 interacts with the C-terminal R2 RING finger domain...
(2016-09-06). "Impaired mitophagy in Fanconi anemia is dependent on mitochondrialfission". Oncotarget. 7 (36): 58065–58074. doi:10.18632/oncotarget.11161...
differentiating humans from apes. PGC-1α is the master regulator of mitochondrial biogenesis. PGC-1α is also the primary regulator of liver gluconeogenesis...
Global Information