dentate gyrus of hippocampal formation granule cell
superior frontal gyrus
visual cortex
lip
primary visual cortex
right lung lobe
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
protein binding
signaling receptor binding
protein-containing complex binding
Cellular component
integral component of membrane
membrane
peroxisomal membrane
peroxisome
mitochondrial outer membrane
mitochondrion
integral component of peroxisomal membrane
endoplasmic reticulum
integral component of mitochondrial outer membrane
protein-containing complex
Biological process
mitochondrial fusion
mitochondrial fission
regulation of mitochondrion organization
positive regulation of cytosolic calcium ion concentration
protein targeting to mitochondrion
peroxisome fission
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
autophagy of mitochondrion
negative regulation of endoplasmic reticulum calcium ion concentration
positive regulation of mitochondrial calcium ion concentration
mitochondrion morphogenesis
calcium-mediated signaling using intracellular calcium source
positive regulation of intrinsic apoptotic signaling pathway
release of cytochrome c from mitochondria
positive regulation of protein targeting to membrane
apoptotic process
response to muscle activity
cellular response to glucose stimulus
cellular response to toxic substance
response to hypobaric hypoxia
positive regulation of neuron apoptotic process
mitochondrial fragmentation involved in apoptotic process
protein homooligomerization
cellular response to lipid
positive regulation of mitochondrial fission
cellular response to peptide
response to flavonoid
response to nutrient levels
response to fluoride
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
51024
66437
Ensembl
ENSG00000214253
ENSMUSG00000019054
UniProt
Q9Y3D6
Q9CQ92
RefSeq (mRNA)
NM_016068
NM_001163243 NM_025562 NM_001347504
RefSeq (protein)
NP_057152
NP_001156715 NP_001334433 NP_079838
Location (UCSC)
Chr 7: 101.24 – 101.25 Mb
Chr 5: 136.98 – 137 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Mitochondrial fission 1 protein (FIS1) is a protein that in humans is encoded by the FIS1 gene on chromosome 7.[5][6][7] This protein is a component of a mitochondrial complex, the ARCosome, that promotes mitochondrial fission.[7][8] Its role in mitochondrial fission thus implicates it in the regulation of mitochondrial morphology, the cell cycle, and apoptosis.[7][8][9][10] By extension, the protein is involved in associated diseases, including neurodegenerative diseases and cancers.[11][12]
^ abcGRCh38: Ensembl release 89: ENSG00000214253 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000019054 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Stojanovski D, Koutsopoulos OS, Okamoto K, Ryan MT (Mar 2004). "Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology". Journal of Cell Science. 117 (Pt 7): 1201–10. doi:10.1242/jcs.01058. PMID 14996942.
^Kong D, Xu L, Yu Y, Zhu W, Andrews DW, Yoon Y, Kuo TH (Apr 2005). "Regulation of Ca2+-induced permeability transition by Bcl-2 is antagonized by Drpl and hFis1". Molecular and Cellular Biochemistry. 272 (1–2): 187–99. doi:10.1007/s11010-005-7323-3. PMID 16010987. S2CID 21452703.
^ abIwasawa R, Mahul-Mellier AL, Datler C, Pazarentzos E, Grimm S (Feb 2011). "Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction". The EMBO Journal. 30 (3): 556–68. doi:10.1038/emboj.2010.346. PMC 3034017. PMID 21183955.
^Gomes LC, Scorrano L (2008). "High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy". Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1777 (7–8): 860–6. doi:10.1016/j.bbabio.2008.05.442. PMID 18515060.
^Lee S, Park YY, Kim SH, Nguyen OT, Yoo YS, Chan GK, Sun X, Cho H (Feb 2014). "Human mitochondrial Fis1 links to cell cycle regulators at G2/M transition". Cellular and Molecular Life Sciences. 71 (4): 711–25. doi:10.1007/s00018-013-1428-8. PMC 11113609. PMID 23907611. S2CID 11694077.
^Wang S, Song J, Tan M, Albers KM, Jia J (Jul 2012). "Mitochondrial fission proteins in peripheral blood lymphocytes are potential biomarkers for Alzheimer's disease". European Journal of Neurology. 19 (7): 1015–22. doi:10.1111/j.1468-1331.2012.03670.x. PMID 22340708. S2CID 21950507.
^Tian Y, Huang Z, Wang Z, Yin C, Zhou L, Zhang L, Huang K, Zhou H, Jiang X, Li J, Liao L, Yang M, Meng F (2014). "Identification of novel molecular markers for prognosis estimation of acute myeloid leukemia: over-expression of PDCD7, FIS1 and Ang2 may indicate poor prognosis in pretreatment patients with acute myeloid leukemia". PLOS ONE. 9 (1): e84150. Bibcode:2014PLoSO...984150T. doi:10.1371/journal.pone.0084150. PMC 3885535. PMID 24416201.
Mitochondrial fission 1 protein (FIS1) is a protein that in humans is encoded by the FIS1 gene on chromosome 7. This protein is a component of a mitochondrial...
adaptor protein Fis1 is an outer membrane protein and associates with Mdv1 and Caf4, which in turn recruit Drp1. The mammalian FIS1 protein does not...
Curia made us, but cast us in a vast field for the dean. 1656) 5 Leopardus fis1 +3 850 1078 """ 1659 SANCTE LEOPARDE ORA PRO NOBIS ANNO 1 6 5 9 (Saint Leopardus...
yeast. The yeast homolog of Drp1 is dynamin-1 (Dnm1), which interacts with Fis1 through Mdv1. This interaction causes Dnm1 to oligomerize and form rings...
upper 5 Georg 1972 Rudolf Perner, Passau 1,090 mm (43 in) 780 kg (1,720 lb) fis1 +10+ South-East, upper 6 Peter 1972 Rudolf Perner, Passau 985 mm (38.8 in)...
mycobacteria with the help of other mitochondrial fission proteins such as DRP1 and FIs1. Under certain conditions, mitochondrial fission and its associated proteins...
DRP1 , OPA1, MFN1, and MFN2 are significantly reduced whereas levels of Fis1 are significantly increased in AD. MFN2 is a key substrate of the PINK1/parkin...
regulate mitochondrial fission by interacting with the proteins Drp1 and FIS1. GRCh38: Ensembl release 89: ENSG00000100335 – Ensembl, May 2017 GRCm38:...
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