Global InformationPhomoxanthone A information
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| Names | |
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| Preferred IUPAC name
rel-(5R,5′R,6R,6′R,10aR,10′aR)-10a,10′a-Bis[(acetyloxy)methyl]-1,1′,8,8′-tetrahydroxy-6,6′-dimethyl-9,9′-dioxo-5,5′,7,7′,9,9′,10a,10′a-octahydro-6H,6′H-[4,4′-bixanthene]-5,5′-diyl diacetate | |
| Other names
PXA
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| Identifiers | |
CAS Number
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3D model (JSmol)
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| ChEBI |
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PubChem CID
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CompTox Dashboard (EPA)
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InChI
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SMILES
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| Properties | |
Chemical formula
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C38H38O16 |
| Molar mass | 750.70 g/mol |
| Appearance | yellow solid |
| Density | ~1.53 g/cm3 |
Solubility in water
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not soluble |
| Solubility in DMSO | good, but unstable[1] |
| Solubility in EtOH | moderate[1] |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
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The mycotoxin phomoxanthone A, or PXA for short, is a toxic natural product that affects the mitochondria. It is the most toxic and the best studied of the naturally occurring phomoxanthones. PXA has recently been shown to induce rapid, non-canonical mitochondrial fission by causing the mitochondrial matrix to fragment while the outer mitochondrial membrane can remain intact. This process was shown to be independent from the mitochondrial fission and fusion regulators DRP1 and OPA1.[1]
- ^ a b c Böhler, Philip; Stuhldreier, Fabian; Anand, Ruchika; Kondadi, Arun Kumar; Schlütermann, David; Berleth, Niklas; Deitersen, Jana; Wallot-Hieke, Nora; Wu, Wenxian; Frank, Marian; Niemann, Hendrik; Wesbuer, Elisabeth; Barbian, Andreas; Luyten, Tomas; Parys, Jan B; Weidtkamp-Peters, Stefanie; Borchardt, Andrea; Reichert, Andreas S; Peña-Blanco, Aida; García-Sáez, Ana J; Itskanov, Samuel; Van Der Bliek, Alexander M; Proksch, Peter; Wesselborg, Sebastian; Stork, Björn (2018). "The mycotoxin phomoxanthone a disturbs the form and function of the inner mitochondrial membrane". Cell Death & Disease. 9 (3): 286. doi:10.1038/s41419-018-0312-8. PMC 5833434. PMID 29459714.