DNM1L information

DNM1L
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3W6N, 3W6O, 3W6P, 4BEJ, 4H1U, 4H1V
Identifiers
Aliases	DNM1L, DLP1, DRP1, DVLP, DYMPLE, EMPF, HDYNIV, dynamin 1-like, dynamin 1 like, EMPF1, OPA5
External IDs	OMIM: 603850; MGI: 1921256; HomoloGene: 6384; GeneCards: DNM1L; OMA:DNM1L - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	32,745,650 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	16,176,823 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; Pars compacta; ; sperm; ; pars reticulata; ; Brodmann area 23; ; external globus pallidus; ; parietal lobe; ; superior vestibular nucleus; ; postcentral gyrus; ; entorhinal cortex;
	Top expressed in
	ventral tegmental area; ; dorsomedial hypothalamic nucleus; ; habenula; ; dorsal tegmental nucleus; ; pontine nuclei; ; medial geniculate nucleus; ; lateral hypothalamus; ; paraventricular nucleus of hypothalamus; ; lateral geniculate nucleus; ; medial dorsal nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein homodimerization activity; GTP binding; protein binding; GTPase activity; identical protein binding; hydrolase activity; ubiquitin protein ligase binding; lipid binding; GTPase activator activity; GTP-dependent protein binding; microtubule binding; clathrin binding; protein-containing complex binding; BH2 domain binding;
Cellular component	cytoplasm; cytosol; Golgi apparatus; membrane; intracellular membrane-bounded organelle; microtubule cytoskeleton; peroxisome; synapse; synaptic vesicle membrane; mitochondrial outer membrane; cell junction; mitochondrion; brush border; perinuclear region of cytoplasm; clathrin-coated pit; microtubule; cytoplasmic vesicle; endomembrane system; endoplasmic reticulum membrane; Golgi membrane; endoplasmic reticulum; mitochondrial membranes; protein-containing complex; postsynapse; presynaptic endocytic zone membrane; mitochondrion-derived vesicle; secretory vesicle;
Biological process	mitochondrial fragmentation involved in apoptotic process; regulation of ATP metabolic process; positive regulation of mitochondrial fission; endocytosis; cellular component disassembly involved in execution phase of apoptosis; mitochondrial fission; regulation of mitochondrion organization; regulation of protein oligomerization; regulation of peroxisome organization; membrane fusion; peroxisome fission; regulation of autophagy of mitochondrion; positive regulation of protein secretion; positive regulation of apoptotic process; protein localization to mitochondrion; positive regulation of release of cytochrome c from mitochondria; necroptosis; dynamin family protein polymerization involved in mitochondrial fission; heart contraction; mitochondrion morphogenesis; protein homotetramerization; mitochondrial membrane fission; positive regulation of intrinsic apoptotic signaling pathway; release of cytochrome c from mitochondria; positive regulation of GTPase activity; protein complex oligomerization; programmed cell death; mitochondrion organization; endoplasmic reticulum organization; apoptotic mitochondrial changes; negative regulation of mitochondrial fusion; synaptic vesicle recycling via endosome; intracellular distribution of mitochondria; synaptic vesicle endocytosis; protein homooligomerization; positive regulation of dendritic spine morphogenesis; cellular response to lipid; cellular response to oxygen-glucose deprivation; execution phase of apoptosis; positive regulation of synaptic vesicle endocytosis; response to flavonoid; response to hypobaric hypoxia; positive regulation of synaptic vesicle exocytosis; calcium ion transport; regulation of gene expression; regulation of ubiquitin protein ligase activity; rhythmic process;
	Sources:Amigo / QuickGO
Orthologs
	10059
	74006
	ENSG00000087470
	ENSMUSG00000022789
	O00429
	Q8K1M6
NM_001278463; NM_001278464; NM_001278465; NM_001278466; NM_005690;
	NM_012062; NM_012063; NM_001330380
NM_001025947; NM_001276340; NM_001276341; NM_152816; NM_001360007;
	NM_001360008; NM_001360009; NM_001360010
NP_001265392; NP_001265393; NP_001265394; NP_001265395; NP_001317309;
	NP_005681; NP_036192; NP_036193
NP_001021118; NP_001263269; NP_001263270; NP_690029; NP_001346936;
	NP_001346937; NP_001346938; NP_001346939; NP_001392181; NP_001392182; NP_001392183; NP_001392184; NP_001392185; NP_001392186; NP_001392187; NP_001392188; NP_001392189; NP_001392190; NP_001392191; NP_001392192; NP_001392193; NP_001392194
	Wikidata
View/Edit Human	View/Edit Mouse

Dynamin-1-like protein is a GTPase that regulates mitochondrial fission. In humans, dynamin-1-like protein, which is typically referred to as dynamin-related protein 1 (Drp1), is encoded by the DNM1L gene and is part of the dynamin superfamily (DSP) family of proteins.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000087470 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022789 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shin HW, Shinotsuka C, Torii S, Murakami K, Nakayama K (September 1997). "Identification and subcellular localization of a novel mammalian dynamin-related protein homologous to yeast Vps1p and Dnm1p". Journal of Biochemistry. 122 (3): 525–30. doi:10.1093/oxfordjournals.jbchem.a021784. PMID 9348079.
^ Hong YR, Chen CH, Cheng DS, Howng SL, Chow CC (August 1998). "Human dynamin-like protein interacts with the glycogen synthase kinase 3beta". Biochemical and Biophysical Research Communications. 249 (3): 697–703. doi:10.1006/bbrc.1998.9253. PMID 9731200.
^ "Entrez Gene: DNM1L dynamin 1-like".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000087470 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022789 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9348079-5] Shin HW, Shinotsuka C, Torii S, Murakami K, Nakayama K (September 1997). "Identification and subcellular localization of a novel mammalian dynamin-related protein homologous to yeast Vps1p and Dnm1p". Journal of Biochemistry. 122 (3): 525–30. doi:10.1093/oxfordjournals.jbchem.a021784. PMID 9348079.

[pmid9731200-6] Hong YR, Chen CH, Cheng DS, Howng SL, Chow CC (August 1998). "Human dynamin-like protein interacts with the glycogen synthase kinase 3beta". Biochemical and Biophysical Research Communications. 249 (3): 697–703. doi:10.1006/bbrc.1998.9253. PMID 9731200.

[entrez-7] "Entrez Gene: DNM1L dynamin 1-like".

DNM1L information

and 4 Related for: DNM1L information

DNM1L

Mitochondrial fission

MUL1

FIS1