RALA information

RALA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UAD, 1ZC3, 1ZC4, 2A78, 2A9K, 2BOV
Identifiers
Aliases	RALA, RAL, RALA Ras like proto-oncogene A, RAS like proto-oncogene A, HINCONS
External IDs	OMIM: 179550; MGI: 1927243; HomoloGene: 3942; GeneCards: RALA; OMA:RALA - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	39,708,120 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	18,118,824 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; buccal mucosa cell; ; amniotic fluid; ; oral cavity; ; gingival epithelium; ; mucosa of pharynx; ; Brodmann area 23; ; skin of hip; ; visceral pleura; ; middle temporal gyrus;
	Top expressed in
	otic placode; ; saccule; ; medial ganglionic eminence; ; otic vesicle; ; Rostral migratory stream; ; atrioventricular valve; ; maxillary prominence; ; human fetus; ; facial motor nucleus; ; endocardial cushion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	Edg-2 lysophosphatidic acid receptor binding; nucleotide binding; GDP binding; myosin binding; ATPase binding; GTP binding; protein binding; GTPase activity; ubiquitin protein ligase binding;
Cellular component	membrane; focal adhesion; myelin sheath; plasma membrane; endocytic vesicle; cleavage furrow; extracellular exosome; cytoplasmic vesicle membrane; cell surface; Flemming body; intracellular anatomical structure;
Biological process	actin cytoskeleton reorganization; cell division; regulation of exocytosis; chemotaxis; neural tube closure; membrane raft localization; cell cycle; membrane organization; viral process; positive regulation of filopodium assembly; signal transduction; exocytosis; Ras protein signal transduction; interleukin-12-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5898
	56044
	ENSG00000006451
	ENSMUSG00000008859
	P11233
	P63321
	NM_005402
	NM_019491
	NP_005393
	NP_062364
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-related protein Ral-A (RalA) is a protein that in humans is encoded by the RALA gene on chromosome 7.^[5]^[6] This protein is one of two paralogs of the Ral protein, the other being RalB, and part of the Ras GTPase family.^[7] RalA functions as a molecular switch to activate a number of biological processes, majorly cell division and transport, via signaling pathways.^[7]^[8]^[9] Its biological role thus implicates it in many cancers.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000006451 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000008859 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rousseau-Merck MF, Bernheim A, Chardin P, Miglierina R, Tavitian A, Berger R (Jun 1988). "The ras-related ral gene maps to chromosome 7p15-22". Human Genetics. 79 (2): 132–6. doi:10.1007/BF00280551. PMID 3292391. S2CID 24522661.
^ "Entrez Gene: RALA v-ral simian leukemia viral oncogene homolog A (ras related)".
^ ^a ^b Simicek M, Lievens S, Laga M, Guzenko D, Aushev VN, Kalev P, Baietti MF, Strelkov SV, Gevaert K, Tavernier J, Sablina AA (Oct 2013). "The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response". Nature Cell Biology. 15 (10): 1220–30. doi:10.1038/ncb2847. PMID 24056301. S2CID 205287526.
^ Tecleab A, Zhang X, Sebti SM (Nov 2014). "Ral GTPase down-regulation stabilizes and reactivates p53 to inhibit malignant transformation". The Journal of Biological Chemistry. 289 (45): 31296–309. doi:10.1074/jbc.M114.565796. PMC 4223330. PMID 25210032.
^ ^a ^b Kashatus DF (Sep 2013). "Ral GTPases in tumorigenesis: emerging from the shadows". Experimental Cell Research. 319 (15): 2337–42. doi:10.1016/j.yexcr.2013.06.020. PMC 4270277. PMID 23830877.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000006451 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000008859 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3292391-5] Rousseau-Merck MF, Bernheim A, Chardin P, Miglierina R, Tavitian A, Berger R (Jun 1988). "The ras-related ral gene maps to chromosome 7p15-22". Human Genetics. 79 (2): 132–6. doi:10.1007/BF00280551. PMID 3292391. S2CID 24522661.

[entrez-6] "Entrez Gene: RALA v-ral simian leukemia viral oncogene homolog A (ras related)".

[pmid24056301-7] Simicek M, Lievens S, Laga M, Guzenko D, Aushev VN, Kalev P, Baietti MF, Strelkov SV, Gevaert K, Tavernier J, Sablina AA (Oct 2013). "The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response". Nature Cell Biology. 15 (10): 1220–30. doi:10.1038/ncb2847. PMID 24056301. S2CID 205287526.

[pmid25210032-8] Tecleab A, Zhang X, Sebti SM (Nov 2014). "Ral GTPase down-regulation stabilizes and reactivates p53 to inhibit malignant transformation". The Journal of Biological Chemistry. 289 (45): 31296–309. doi:10.1074/jbc.M114.565796. PMC 4223330. PMID 25210032.

[pmid23830877-9] Kashatus DF (Sep 2013). "Ral GTPases in tumorigenesis: emerging from the shadows". Experimental Cell Research. 319 (15): 2337–42. doi:10.1016/j.yexcr.2013.06.020. PMC 4270277. PMID 23830877.

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