Mitochondrial fission factor (Mff) is a protein that in humans is encoded by the MFF gene.[5] Its primary role is in controlling the division of mitochondria. Mitochondrial morphology changes by continuous fission in order to create interconnected network of mitochondria. This activity is crucial for normal function of mitochondria.[6] Mff is anchored to the mitochondrial outer membrane through the C-terminal transmembrane domain, extruding the bulk of the N-terminal portion containing two short amino acid repeats in the N-terminal half and a coiled-coil domain just upstream of the transmembrane domain into the cytosol.[7] It has also been shown to regulate peroxisome morphology.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000168958 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000026150 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: mitochondrial fission factor".
^Otera H, Wang C, Cleland MM, Setoguchi K, Yokota S, Youle RJ, Mihara K (December 2010). "Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells". The Journal of Cell Biology. 191 (6): 1141–1158. doi:10.1083/jcb.201007152. PMC 3002033. PMID 21149567.
^Otera H, Wang C, Cleland MM, Setoguchi K, Yokota S, Youle RJ, Mihara K (2010-12-13). "Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells". Journal of Cell Biology. 191 (6): 1141–1158. doi:10.1083/jcb.201007152. ISSN 1540-8140. PMC 3002033. PMID 21149567.
^Gandre-Babbe S, van der Bliek AM (June 2008). "The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells". Molecular Biology of the Cell. 19 (6): 2402–2412. doi:10.1091/mbc.E07-12-1287. PMC 2397315. PMID 18353969.
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Mitochondrialfissionfactor (Mff) is a protein that in humans is encoded by the MFF gene. Its primary role is in controlling the division of mitochondria...
Mitochondrialfission is the process where mitochondria divide or segregate into two separate mitochondrial organelles. Mitochondrialfission is counteracted...
balance of fission and fusion in a cell, it could significantly alter the mitochondrial network. For example, an increase in mitochondrialfission would create...
division of the cytoplasm. Mitochondrial dynamics, the balance between mitochondrial fusion and fission, is an important factor in pathologies associated...
non-profit chemistry organization MFF (gene), encodes the protein mitochondrialfissionfactor MFF SIM, SIM cards for machine use Manly Fast Ferry, ferry operator...
limiting factor in mitochondrialfission. After the mitochondrion has enough mtDNA, membrane area, and membrane proteins, it can undergo fission (very similar...
assist in mitochondrial binary fission. It is a dynamic peripheral protein receptor found on the surface of the mitochondrial membrane. MID51 is a very similar...
mitochondrion, there may be random segregation of the chromosomes during mitochondrialfission to generate new mitochondria. This can give rise to a mitochondrion...
healthy mitochondria. Furthermore, mutations in both Drp1, a mitochondrialfissionfactor, and PINK1 were fatal in Drosophila models. However, an over-expression...
"The COX18 gene, involved in mitochondrial biogenesis, is functionally conserved and tightly regulated in humans and fission yeast". FEMS Yeast Research...
Dynamin-1-like protein is a GTPase that regulates mitochondrialfission. In humans, dynamin-1-like protein, which is typically referred to as dynamin-related...
regulates inner mitochondrial membrane fusion, MFN1 is a mediator of mitochondrial fusion and DRP1 is responsible for mitochondrialfission. The human mitofusin-2...
whose copies of mitochondrial DNA are all identical. In normal and healthy tissues, all cells are homoplasmic. Homoplasmic mitochondrial DNA copies may...
by context-dependent constant fission and fusion. Fission is crucial for mitophagy, as it cuts off a small mitochondrial part that can be further engulfed...
an increase in reactive oxygen species, mitochondrial swelling and fission, and an increase in mitochondrial turnover via autophagy. Sequence similarity...
mitochondrialfission and fusion, lipid concentration of the mitochondrial membranes, and the mitochondrial permeability transition. Mitochondrial disease...
contact sites also regulate early and late endosome fission, RNA granule division, and mitochondrial fusion. These works establish the ER network as a master...
Animalia, Plantae, Fungi, and Protista. They both reproduce through binary fission. Bacteria, the most prominent type, have several different shapes, although...
F (December 2006). "The cell-end factor pom1p inhibits mid1p in specification of the cell division plane in fission yeast". Curr. Biol. 16 (24): 2480–7...
Lipton SA (August 2010). "S-nitrosylation of Drp1 links excessive mitochondrialfission to neuronal injury in neurodegeneration". Mitochondrion. 10 (5):...
triggers mitochondrialfission, leads to a loss of mitochondrial membrane potential and causes host cell death. Fission is also linked to mitochondrial Bax/Bak...
(February 2021). "Function and regulation of the divisome for mitochondrialfission". Nature. 590 (7844): 57–66. doi:10.1038/s41586-021-03214-x. ISSN 1476-4687...
junction resolvase from the fission yeast Schizosaccharomyces pombe that is involved in the maintenance of mitochondrial DNA. In molecular biology, the...
in the relocation of RalA to the inner mitochondrial membrane, where RalA helps carry out mitochondrialfission; whereas phosphorylation of Serine 198...
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