Merging of two or more mitochondria within a cell to form a single compartment
Mitochondria are dynamic organelles with the ability to fuse and divide (fission), forming constantly changing tubular networks in most eukaryotic cells. These mitochondrial dynamics, first observed over a hundred years ago[1] are important for the health of the cell, and defects in dynamics lead to genetic disorders. Through fusion, mitochondria can overcome the dangerous consequences of genetic malfunction.[2] The process of mitochondrial fusion involves a variety of proteins that assist the cell throughout the series of events that form this process.
Mitochondrial network (green) in two human cells (HeLa cells)Mitochondria, mammalian lung - TEM (2)
^Lewis, Margaret (1915). "Mitochondria (and other cytoplamic structures) in tissue cultures" (PDF). American Journal of Anatomy. 17 (3): 339–401. doi:10.1002/aja.1000170304.
^Hales, Karen G. (2010). "Mitochondrial Fusion and Division". Nature Education. 3 (9): 12. Retrieved 23 November 2014.
and 23 Related for: Mitochondrial fusion information
stresses, mitochondrialfusion and fission work to maintain functional mitochondria. An increase in fusion activity leads to mitochondrial elongation...
for mitochondrialfusion. In addition to the mitofusins, OPA1 regulates inner mitochondrial membrane fusion, and DRP1 is responsible for mitochondrial fission...
Critically, mitochondrial numbers and morphology vary according to cell type and context-specific demand, whereby the balance between mitochondrialfusion/fission...
cells during the division of the cytoplasm. Mitochondrial dynamics, the balance between mitochondrialfusion and fission, is an important factor in pathologies...
by the process of mitochondrialfusion, whereby two separate mitochondria can fuse together to form a large one. Mitochondrialfusion in turn can result...
mediator of mitochondrialfusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane...
Human mitochondrial genetics is the study of the genetics of human mitochondrial DNA (the DNA contained in human mitochondria). The human mitochondrial genome...
routinely undergo fission and fusion events that maintain a dynamic reticular network. Drp1 is a fundamental component of mitochondrial fission. Indeed, Drp1...
Duan X, Shang W, Fan HY, Tong C (2016). "Mitoguardin Regulates MitochondrialFusion through MitoPLD and Is Required for Neuronal Homeostasis". Mol. Cell...
Mitochondrial fission factor (Mff) is a protein that in humans is encoded by the MFF gene. Its primary role is in controlling the division of mitochondria...
as NO, can trigger aberrant mitochondrial fission and fusion, resulting in mitophagy. For example, increased mitochondrial fragmentation and FIS1 levels...
Tondera D, et al. (December 2009). "Regulation of OPA1 processing and mitochondrialfusion by m-AAA protease isoenzymes and OMA1". The Journal of Cell Biology...
(19 December 2013). "Horizontal Transfer of Entire Genomes via MitochondrialFusion in the Angiosperm Amborella". Science. 342 (6165): 1468–1473. Bibcode:2013Sci...
as the whole cell partner in the fusion. Rho-zero cells are cells which have been depleted of their own mitochondrial DNA by prolonged incubation with...
mediate eukaryotic membrane fusion and fission necessary for endocytosis, organelle biogenesis and maintenance, Mitochondrialfusion and fission, as well as...
Poderoso, C., Cooke, M., Soria, G., Cornejo Maciel, F., et al. (2012). Mitochondrialfusion is essential for steroid biosynthesis. PLoS ONE, 7(9): e45829. Porterfield...
context-dependent constant fission and fusion. Fission is crucial for mitophagy, as it cuts off a small mitochondrial part that can be further engulfed by...
the outer mitochondrial membrane by forming homo- and hetero-oligomers inside the membrane. Upregulation results in a decrease in mitochondrial potential...
ubiquitination of Drp1 and a knockdown of MARCH5 is by RNAi led to abnormal mitochondrialfusion. Further evidences show that MARCH 5 specifically interacts with...
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