Organelle in eukaryotic cells responsible for respiration
"Mitochondria" redirects here. For the song by Kenichi Suzumura, see Mitochondria (song). For the Canadian band, see Mitochondrion (band).
A mitochondrion (/ˌmaɪtəˈkɒndriən/;[1] pl.: mitochondria) is an organelle found in the cells of most eukaryotes, such as animals, plants and fungi. Mitochondria have a double membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which is used throughout the cell as a source of chemical energy.[2] They were discovered by Albert von Kölliker in 1857[3] in the voluntary muscles of insects. The term mitochondrion was coined by Carl Benda in 1898. The mitochondrion is popularly nicknamed the "powerhouse of the cell", a phrase coined by Philip Siekevitz in a 1957 article of the same name.[4]
Some cells in some multicellular organisms lack mitochondria (for example, mature mammalian red blood cells). The multicellular animal Henneguya salminicola is known to have retained mitochondrion-related organelles in association with a complete loss of their mitochondrial genome.[5][6][7] A large number of unicellular organisms, such as microsporidia, parabasalids and diplomonads, have reduced or transformed their mitochondria into other structures,[8] e.g. hydrogenosomes and mitosomes.[9] The oxymonads Monocercomonoides, Streblomastix, and Blattamonas have completely lost their mitochondria.[5][10]
Mitochondria are commonly between 0.75 and 3 μm2 in cross section,[11] but vary considerably in size and structure. Unless specifically stained, they are not visible. In addition to supplying cellular energy, mitochondria are involved in other tasks, such as signaling, cellular differentiation, and cell death, as well as maintaining control of the cell cycle and cell growth.[12] Mitochondrial biogenesis is in turn temporally coordinated with these cellular processes.[13][14] Mitochondria have been implicated in several human disorders and conditions, such as mitochondrial diseases,[15] cardiac dysfunction,[16] heart failure[17] and autism.[18]
The number of mitochondria in a cell can vary widely by organism, tissue, and cell type. A mature red blood cell has no mitochondria,[19] whereas a liver cell can have more than 2000.[20][21] The mitochondrion is composed of compartments that carry out specialized functions. These compartments or regions include the outer membrane, intermembrane space, inner membrane, cristae, and matrix.
Although most of a eukaryotic cell's DNA is contained in the cell nucleus, the mitochondrion has its own genome ("mitogenome") that is substantially similar to bacterial genomes.[22] This finding has led to general acceptance of the endosymbiotic hypothesis - that free-living prokaryotic ancestors of modern mitochondria permanently fused with eukaryotic cells in the distant past, evolving such that modern animals, plants, fungi, and other eukaryotes are able to respire to generate cellular energy.[23]
^"mitochondrion". Lexico UK English Dictionary. Oxford University Press. Archived from the original on January 2, 2020.
^Campbell NA, Williamson B, Heyden RJ (2006). Biology: Exploring Life. Boston, Massachusetts: Pearson/Prentice Hall. ISBN 978-0132508827. Archived from the original on November 2, 2014. Retrieved January 6, 2009.
^"Mighty Mitochondria and Neurodegenerative Diseases". Science in the News. February 1, 2012. Archived from the original on April 6, 2022. Retrieved April 24, 2022.
^Cite error: The named reference Siekevitz was invoked but never defined (see the help page).
^ abCite error: The named reference CB1 was invoked but never defined (see the help page).
^Le Page M. "Animal that doesn't need oxygen to survive discovered New Scientist". New Scientist. Archived from the original on February 26, 2020. Retrieved February 25, 2020.
^Yahalomi D, Atkinson SD, Neuhof M, Chang ES, Philippe H, Cartwright P, et al. (March 2020). "A cnidarian parasite of salmon (Myxozoa: Henneguya) lacks a mitochondrial genome". Proceedings of the National Academy of Sciences of the United States of America. 117 (10): 5358–5363. Bibcode:2020PNAS..117.5358Y. doi:10.1073/pnas.1909907117. PMC 7071853. PMID 32094163.
^Henze K, Martin W (November 2003). "Evolutionary biology: essence of mitochondria". Nature. 426 (6963): 127–128. Bibcode:2003Natur.426..127H. doi:10.1038/426127a. PMID 14614484. S2CID 862398.
^Leger, Michelle M.; Kolisko, Martin; Kamikawa, Ryoma; Stairs, Courtney W.; Kume, Keitaro; Čepička, Ivan; Silberman, Jeffrey D.; Andersson, Jan O.; Xu, Feifei; Yabuki, Akinori; Eme, Laura; Zhang, Qianqian; Takishita, Kiyotaka; Inagaki, Yuji; Simpson, Alastair G. B. (March 13, 2017). "Organelles that illuminate the origins of Trichomonas hydrogenosomes and Giardia mitosomes". Nature Ecology & Evolution. 1 (4): 0092. Bibcode:2017NatEE...1...92L. doi:10.1038/s41559-017-0092. ISSN 2397-334X. PMC 5411260. PMID 28474007.
^Cite error: The named reference :1 was invoked but never defined (see the help page).
^Wiemerslage L, Lee D (March 2016). "Quantification of mitochondrial morphology in neurites of dopaminergic neurons using multiple parameters". Journal of Neuroscience Methods. 262: 56–65. doi:10.1016/j.jneumeth.2016.01.008. PMC 4775301. PMID 26777473.
^Cite error: The named reference McBrideNeuspiel2006 was invoked but never defined (see the help page).
^Valero T (2014). "Mitochondrial biogenesis: pharmacological approaches". Current Pharmaceutical Design. 20 (35): 5507–5509. doi:10.2174/138161282035140911142118. hdl:10454/13341. PMID 24606795. Mitochondrial biogenesis is therefore defined as the process via which cells increase their individual mitochondrial mass [3]. ... Mitochondrial biogenesis occurs by growth and division of pre-existing organelles and is temporally coordinated with cell cycle events [1].
^Sanchis-Gomar F, García-Giménez JL, Gómez-Cabrera MC, Pallardó FV (2014). "Mitochondrial biogenesis in health and disease. Molecular and therapeutic approaches". Current Pharmaceutical Design. 20 (35): 5619–5633. doi:10.2174/1381612820666140306095106. PMID 24606801. Mitochondrial biogenesis (MB) is the essential mechanism by which cells control the number of mitochondria
^Gardner A, Boles RG (2005). "Is a 'Mitochondrial Psychiatry' in the Future? A Review". Curr. Psychiatry Rev. 1 (3): 255–271. doi:10.2174/157340005774575064.
^Lesnefsky EJ, Moghaddas S, Tandler B, Kerner J, Hoppel CL (June 2001). "Mitochondrial dysfunction in cardiac disease: ischemia – reperfusion, aging, and heart failure". Journal of Molecular and Cellular Cardiology. 33 (6): 1065–1089. doi:10.1006/jmcc.2001.1378. PMID 11444914.
^Dorn GW, Vega RB, Kelly DP (October 2015). "Mitochondrial biogenesis and dynamics in the developing and diseased heart". Genes & Development. 29 (19): 1981–1991. doi:10.1101/gad.269894.115. PMC 4604339. PMID 26443844.
^Griffiths KK, Levy RJ (2017). "Evidence of Mitochondrial Dysfunction in Autism: Biochemical Links, Genetic-Based Associations, and Non-Energy-Related Mechanisms". Oxidative Medicine and Cellular Longevity. 2017: 4314025. doi:10.1155/2017/4314025. PMC 5467355. PMID 28630658.
^Ney PA (May 2011). "Normal and disordered reticulocyte maturation". Current Opinion in Hematology. 18 (3): 152–157. doi:10.1097/MOH.0b013e328345213e. PMC 3157046. PMID 21423015.
^Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P (2005). Molecular Biology of the Cell. New York: Garland Publishing Inc. ISBN 978-0815341055.
^Voet D, Voet JC, Pratt CW (2006). Fundamentals of Biochemistry (2nd ed.). John Wiley and Sons, Inc. pp. 547, 556. ISBN 978-0471214953.
^Andersson SG, Karlberg O, Canbäck B, Kurland CG (January 2003). "On the origin of mitochondria: a genomics perspective". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 358 (1429): 165–77, discussion 177–9. doi:10.1098/rstb.2002.1193. PMC 1693097. PMID 12594925.
^Gabaldón T (October 2021). "Origin and Early Evolution of the Eukaryotic Cell". Annual Review of Microbiology. 75 (1): 631–647. doi:10.1146/annurev-micro-090817-062213. PMID 34343017. S2CID 236916203.
A mitochondrion (/ˌmaɪtəˈkɒndriən/; pl.: mitochondria) is an organelle found in the cells of most eukaryotes, such as animals, plants and fungi. Mitochondria...
eukaryotic cells, the citric acid cycle occurs in the matrix of the mitochondrion. In prokaryotic cells, such as bacteria, which lack mitochondria, the...
crista (/ˈkrɪstə/; pl.: cristae) is a fold in the inner membrane of a mitochondrion. The name is from the Latin for crest or plume, and it gives the inner...
relatives of the Opisthokonts, a group that includes animals and fungi. Mitochondrion-related organelles (MROs) are organelles that evolved from a degradation...
Cell biology mitochondrion Components of a typical mitochondrion 1 Outer membrane 1.1 Porin 2 Intermembrane space 2.1 Intracristal space 2.2 Peripheral...
the cytoplasm. Mitochondria are organelles in eukaryotic cells. The mitochondrion is commonly called "the powerhouse of the cell", for its function providing...
have multiple chromosomes in the mitochondrion. This and the phylogenetics of the genes encoded within the mitochondrion suggest that mitochondria have...
In molecular biology, housekeeping genes are typically constitutive genes that are required for the maintenance of basic cellular function, and are expressed...
which enters the mitochondrion where it is converted into acetyl-CoA and then into citrate. Excess citrate is exported from the mitochondrion back into the...
mitosome, both conventionally considered "mitochondrion-derived organelles", would predate the mitochondrion, and instead be derived from the earlier symbiotic...
depending on the source of the genetic code, such as from a cell nucleus, mitochondrion, plastid, or hydrogenosome. There are 64 different codons in the genetic...
In the mitochondrion, the matrix is the space within the inner membrane. The word "matrix" stems from the fact that this space is viscous, compared to...
and possess normal eukaryotic organelles, for example the nucleus, mitochondrion, golgi apparatus and flagellum. Along with these universal structures...
coming from glycolysis, because pyruvate is not transferred to the mitochondrion and finally oxidized to the carbon dioxide (CO2), but reduced to ethanol...
A mitosome (also called a crypton in early literature) is a mitochondrion-related organelle (MRO) found in a variety of parasitic unicellular eukaryotes...
inorganic phosphate, and fructose-1,6- and -2,6-biphosphate. In the mitochondrion, pyruvate is oxidized by the pyruvate dehydrogenase complex to the acetyl...
as the region between the inner membrane and the outer membrane of a mitochondrion or a chloroplast. It also refers to the space between the inner and...
a process of fermentation. The pyruvate is not transported into the mitochondrion but remains in the cytoplasm, where it is converted to waste products...
and Miklós Müller in 1998 that describes a possible way in which the mitochondrion arose as an endosymbiont within a prokaryotic host in the archaea, giving...