Mitochondrial biogenesis is the process by which cells increase mitochondrial numbers.[1][2] It was first described by John Holloszy in the 1960s, when it was discovered that physical endurance training induced higher mitochondrial content levels, leading to greater glucose uptake by muscles.[3] Mitochondrial biogenesis is activated by numerous different signals during times of cellular stress or in response to environmental stimuli, such as aerobic exercise.[1][2][4]
^ abSanchis-Gomar F, García-Giménez JL, Gómez-Cabrera MC, Pallardó FV (2014). "Mitochondrial biogenesis in health and disease. Molecular and therapeutic approaches". Current Pharmaceutical Design. 20 (35): 5619–33. doi:10.2174/1381612820666140306095106. PMID 24606801.
^Holloszy JO (April 2011). "RRegulation of Mitochondrial Biogenesis and GLUT4 Expression by Exercise". Comprehensive Physiology. 1 (2): 921–40. doi:10.1002/cphy.c100052. ISBN 9780470650714. PMID 23737207.
^Boushel R, Lundby C, Qvortrup K, Sahlin K (October 2014). "Mitochondrial plasticity with exercise training and extreme environments". Exercise and Sport Sciences Reviews. 42 (4): 169–74. doi:10.1249/JES.0000000000000025. PMID 25062000. S2CID 39267910.
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Mitochondrialbiogenesis is the process by which cells increase mitochondrial numbers. It was first described by John Holloszy in the 1960s, when it was...
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outer membrane mitochondrial proteins carry out functions for mitochondrialbiogenesis and integration between mitochondria and the cellular system. The...
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Gaisne M, Bonnefoy N (September 2006). "The COX18 gene, involved in mitochondrialbiogenesis, is functionally conserved and tightly regulated in humans and...
expenditure. This is achieved through several mechanisms, such as mitochondrialbiogenesis, adaptive thermogenesis, etc. American chemist Edward Calvin Kendall...
was inversely correlated with PGC-1α activation, which drives mitochondrialbiogenesis. In support of these data, FLCN inactivation was correlated with...
endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrialbiogenesis". Genomics. 25 (2): 559–64. doi:10.1016/0888-7543(95)80058-T. PMID 7789991...
effect of high-fat feeding. FEBS Lett. 582: 510–516. Increase in mitochondrialbiogenesis, oxidative stress, and glycolysis in murine lymphomas Enrique Sampera...
resistance. Mitochondrial dysfunction may result from the formation of reactive oxygen species, genetic factors, aging, and reduced mitochondrialbiogenesis. Important...
Organelle biogenesis is the biogenesis, or creation, of cellular organelles in cells. Organelle biogenesis includes the process by which cellular organelles...
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phenotype, with a coordinated increase in oxidative enzymes and mitochondrialbiogenesis and an increased proportion of ST fibers. Thus—through functional...
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