dentate gyrus of hippocampal formation granule cell
cerebellar cortex
esophagus
primary visual cortex
Cortex of frontal lobe
superior frontal gyrus
hippocampus proper
muscle of thigh
jejunum
ganglionic eminence
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
cytochrome-c oxidase activity
metal ion binding
protein binding
heme binding
oxidoreductase activity
Cellular component
integral component of membrane
membrane
mitochondrion
mitochondrial inner membrane
respirasome
respiratory chain complex IV
mitochondrial respiratory chain complex III
mitochondrial respiratory chain complex IV
Biological process
response to copper ion
human ageing
response to electrical stimulus
response to oxidative stress
cerebellum development
oxidative phosphorylation
mitochondrial electron transport, cytochrome c to oxygen
aerobic respiration
electron transport coupled proton transport
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
4512
17708
Ensembl
ENSG00000198804
ENSMUSG00000064351
UniProt
P00395
P00397
RefSeq (mRNA)
n/a
n/a
RefSeq (protein)
n/a
NP_904330
Location (UCSC)
Chr M: 0.01 – 0.01 Mb
Chr M: 0.01 – 0.01 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Cytochrome c oxidase subunit I
Structure of the 13-subunit oxidized cytochrome c oxidase.[5]
Identifiers
Symbol
COX1 or COI
Pfam
PF00115
InterPro
IPR000883
PROSITE
PDOC00074
SCOP2
1occ / SCOPe / SUPFAM
TCDB
3.D.4
OPM superfamily
4
OPM protein
1v55
CDD
cd01663
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Location of the MT-CO1 gene in the human mitochondrial genome. MT-CO1 is one of the three cytochrome c oxidase subunit mitochondrial genes (orange boxes).
Cytochrome c oxidase I (COX1) also known as mitochondrially encoded cytochrome c oxidase I (MT-CO1) is a protein that is encoded by the MT-CO1 gene in eukaryotes.[6] The gene is also called COX1, CO1, or COI.[7] Cytochrome c oxidase I is the main subunit of the cytochrome c oxidase complex. In humans, mutations in MT-CO1 have been associated with Leber's hereditary optic neuropathy (LHON), acquired idiopathic sideroblastic anemia, Complex IV deficiency, colorectal cancer, sensorineural deafness, and recurrent myoglobinuria.[8][9][10]
^ abcGRCh38: Ensembl release 89: ENSG00000198804 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000064351 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Tsukihara T, Aoyama H, Yamashita E, Tomizaki T, Yamaguchi H, Shinzawa-Itoh K, et al. (May 1996). "The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A". Science. 272 (5265): 1136–1144. Bibcode:1996Sci...272.1136T. doi:10.1126/science.272.5265.1136. PMID 8638158. S2CID 20860573.
^"Entrez Gene: Cytochrome c oxidase subunit I".
^Kosakyan A, Heger TJ, Leander BS, Todorov M, Mitchell EA, Lara E (May 2012). "COI barcoding of Nebelid testate amoebae (Amoebozoa: Arcellinida): extensive cryptic diversity and redefinition of the Hyalospheniidae Schultze" (PDF). Protist. 163 (3): 415–434. doi:10.1016/j.protis.2011.10.003. PMID 22130576.
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^Cite error: The named reference :3 was invoked but never defined (see the help page).
and 27 Related for: Cytochrome c oxidase subunit I information
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III itself is composed of several subunits, one of which is a b-type cytochrome while another one is a c-type cytochrome. Both domains are involved in electron...
III (cytochrome bc1 complex; labeled III), which passes them to cytochromec (cyt c). Cyt c passes electrons to Complex IV (cytochromecoxidase; labeled...
Annelida), assessed from 18SrRNA, 28SrRNA, 16SrRNA, mitochondrial cytochromecoxidasesubunitI (COI), and morphology". Molecular Phylogenetics and Evolution...
Atlantic S. antillensis with a 10.2% sequence divergence in the cytochromecoxidasesubunitI gene. In a nod to the species' namesake, the paper describing...
based on 18S ribosomal RNA, 28S ribosomal RNA, and partial cytochromecoxidasesubunitI (COI) genes shows phylogenic relations of species in the genus...
Annelida), assessed from 18SrRNA, 28SrRNA, 16SrRNA, mitochondrial cytochromecoxidasesubunitI (COI), and morphology". Molecular Phylogenetics and Evolution...
the southernmost location to this date. Two haplotypes of the CytochromecoxidasesubunitI (a mitochondrial gene commonly used for DNA barcoding) sequence...
1955 Clavelina viola Tokioka & Nishikawa, 1976 A 2024 study of cytochromecoxidasesubunitI gene sequences found that Clavelina was paraphyletic to the...
Yaono R, Yoshikawa S (1996). "The whole structure of the 13-subunit oxidized cytochromecoxidase at 2.8 A". Science. 272 (5265): 1136–44. Bibcode:1996Sci...
and Chile Recent findings from a phylogenetic study using the CytochromecoxidasesubunitI and the 18S genes showed that Maindronia neotropicalis, inhabiting...
brown-orange color if the cells produce a mitochondrial protein called cytochromecoxidasesubunitI (CCOI or COX-1). The nuclei of the cells (located at the outer...
its walking legs, and color pattern) and its mitochondrial cytochromecoxidasesubunitI sequences. Macpherson, E.; Machordom, A. (2001). "Phylogenetic...
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