The type III interferon group is a group of anti-viral cytokines, that consists of four IFN-λ (lambda) molecules called IFN-λ1, IFN-λ2, IFN-λ3 (also known as IL29, IL28A and IL28B respectively), and IFN-λ4.[1] They were discovered in 2003.[2] Their function is similar to that of type I interferons, but is less intense and serves mostly as a first-line defense against viruses in the epithelium.[3]
^Kotenko SV, Gallagher G, Baurin VV, Lewis-Antes A, Shen M, Shah NK, et al. (January 2003). "IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex". Nature Immunology. 4 (1): 69–77. doi:10.1038/ni875. PMID 12483210. S2CID 2734534.
^Kotenko SV, Durbin JE (May 2017). "Contribution of type III interferons to antiviral immunity: location, location, location". The Journal of Biological Chemistry. 292 (18): 7295–7303. doi:10.1074/jbc.R117.777102. PMC 5418032. PMID 28289095.
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The typeIIIinterferon group is a group of anti-viral cytokines, that consists of four IFN-λ (lambda) molecules called IFN-λ1, IFN-λ2, IFN-λ3 (also known...
induction of Th1 immune response. IFN type II binds to IFNGR, which consists of IFNGR1 and IFNGR2 chains. InterferontypeIII: Signal through a receptor complex...
The type-I interferons (IFN) are cytokines which play essential roles in inflammation, immunoregulation, tumor cells recognition, and T-cell responses...
respond to a select group of cytokines including interferontype I, interferontype II, interferontypeIII. and members of the interleukin-10 family These...
Interferon gamma (IFNG or IFN-γ) is a dimerized soluble cytokine that is the only member of the type II class of interferons. The existence of this interferon...
Interleukin 5 Interleukin 6 Granulocyte-macrophage colony-stimulating factor Interferon-gamma Julius M. Cruse; Robert Edwin Lewis (20 April 2009). Illustrated...
'movement'. Interferon-alpha, an interferontype I, was identified in 1957 as a protein that interfered with viral replication. The activity of interferon-gamma...
induces type I interferon production when cells are infected with intracellular pathogens, such as viruses, mycobacteria and intracellular parasites. Type I...
stimulate the growth and function of T cells. It stimulates the production of interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) from T cells and...
proliferation of further CD4+ Th1 cells. CD4+ T cells secrete IL-2 and interferon gamma (IFNγ), inducing the further release of other Th1 cytokines, thus...
in 2002 by two independent groups of researchers. Irisin (fibronectin typeIII domain-containing protein 5 or FNDC5), a recently described myokine hormone...
S2CID 85495400. Apte SH, Baz A, Groves P, Kelso A, Kienzle N (November 2008). "Interferon-gamma and interleukin-4 reciprocally regulate CD8 expression in CD8+ T...
alpha interferons, but the Ueda team deemed it an "omega-type" interferon due to some motifs. Phylogenic analysis in 2007 puts it as an alpha-type interferon...
the unique ability to give rise to all of the different mature blood cell types and tissues. HSCs are self-renewing cells: when they differentiate, at least...
recently reviewed. There are 3 types of IFNs: Interferontype I, Interferontype II and InterferontypeIII. The type II IFN, also called IFNγ, is produced...
killer cells also express the IL-23 receptor. They respond with increased interferon-γ secretion and enhanced antibody-dependent cellular cytotoxicity. IL-23...
C-X-C motif chemokine ligand 10 (CXCL10) also known as Interferon gamma-induced protein 10 (IP-10) or small-inducible cytokine B10 is an 8.7 kDa protein...
6 (IL6), also referred to as B-cell stimulatory factor-2 (BSF-2) and interferon beta-2, is a cytokine involved in a wide variety of biological functions...
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