positive regulation of transcription by RNA polymerase II
positive regulation of defense response to virus by host
apoptotic process
innate immune response
neutrophil degranulation
cellular response to organic cyclic compound
viral process
positive regulation of DNA-binding transcription factor activity
positive regulation of type I interferon production
regulation of gene expression
regulation of cellular metabolic process
regulation of inflammatory response
cytoplasmic pattern recognition receptor signaling pathway in response to virus
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
340061
72512
Ensembl
ENSG00000184584 ENSG00000288243
ENSMUSG00000024349
UniProt
Q86WV6
Q3TBT3
RefSeq (mRNA)
NM_001301738 NM_198282 NM_001367258
NM_001289591 NM_001289592 NM_028261
RefSeq (protein)
NP_001288667 NP_938023 NP_001354187
NP_001276520 NP_001276521 NP_082537
Location (UCSC)
Chr 5: 139.48 – 139.48 Mb
Chr 18: 35.87 – 35.87 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Stimulator of interferon genes (STING), also known as transmembrane protein 173 (TMEM173) and MPYS/MITA/ERIS is a protein that in humans is encoded by the STING1 gene.[5]
STING plays an important role in innate immunity. STING induces type I interferon production when cells are infected with intracellular pathogens, such as viruses, mycobacteria and intracellular parasites.[6] Type I interferon, mediated by STING, protects infected cells and nearby cells from local infection by binding to the same cell that secretes it (autocrine signaling) and nearby cells (paracrine signaling.) It thus plays an important role, for instance, in controlling norovirus infection.[7]
STING works as both a direct cytosolic DNA sensor (CDS) and an adaptor protein in Type I interferon signaling through different molecular mechanisms. It has been shown to activate downstream transcription factors STAT6 and IRF3 through TBK1, which are responsible for antiviral response and innate immune response against intracellular pathogen.[8]
^ abcGRCm38: Ensembl release 89: ENSMUSG00000024349 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"STING1 stimulator of interferon response cGAMP interactor 1 [ Homo sapiens (human) ]".
^Nakhaei P, Hiscott J, Lin R (Jun 2010). "STING-ing the antiviral pathway". Journal of Molecular Cell Biology. 2 (3): 110–2. doi:10.1093/jmcb/mjp048. PMID 20022884.
^NYu P, Miao Z, Li Y, Bansal R, Peppelenbosch MP, Pan Q (2021). "cGAS-STING effectively restricts murine norovirus infection but antagonizes the antiviral action of N-terminus of RIG-I in mouse macrophage". Gut Microbes. 13 (1): 1959839. doi:10.1080/19490976.2021.1959839. ISSN 1949-0976. PMC 8344765. PMID 34347572.
^Cite error: The named reference pmid23238760 was invoked but never defined (see the help page).
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Global Information
