double-stranded DNA 5'-3' exodeoxyribonuclease activity
single-stranded DNA 5'-3' exodeoxyribonuclease activity
DNA binding
5'-3' exonuclease activity
nuclease activity
RNA-DNA hybrid ribonuclease activity
protein binding
5'-3' exodeoxyribonuclease activity
flap endonuclease activity
chromatin binding
exonuclease activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
metal ion binding
double-stranded DNA binding
5'-flap endonuclease activity
Cellular component
nucleus
nucleoplasm
nuclear body
plasma membrane
Biological process
DNA recombination
immune system process
humoral immune response mediated by circulating immunoglobulin
DNA mismatch repair
cellular response to DNA damage stimulus
somatic hypermutation of immunoglobulin genes
meiosis
isotype switching
DNA repair
RNA phosphodiester bond hydrolysis, endonucleolytic
nucleic acid phosphodiester bond hydrolysis
DNA replication
t-circle formation
meiotic DNA double-strand break processing
regulation of signal transduction by p53 class mediator
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
9156
26909
Ensembl
ENSG00000174371
ENSMUSG00000039748
UniProt
Q9UQ84 Q5T397
Q9QZ11
RefSeq (mRNA)
NM_003686 NM_006027 NM_130398 NM_001319224
NM_012012
RefSeq (protein)
NP_001306153 NP_003677 NP_006018 NP_569082
NP_036142
Location (UCSC)
Chr 1: 241.85 – 241.9 Mb
Chr 1: 175.71 – 175.74 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Exonuclease 1 is an enzyme that in humans is encoded by the EXO1 gene.[5][6][7]
This gene encodes a protein with 5' to 3' exonuclease activity as well as RNase activity (endonuclease activity cleaving RNA on DNA/RNA hybrid).[8] It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in DNA mismatch repair and homologous recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000174371 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000039748 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Wilson DM III, Carney JP, Coleman MA, Adamson AW, Christensen M, Lamerdin JE (September 1998). "Hex1: a new human Rad2 nuclease family member with homology to yeast exonuclease 1". Nucleic Acids Res. 26 (16): 3762–8. doi:10.1093/nar/26.16.3762. PMC 147753. PMID 9685493.
^Schmutte C, Marinescu RC, Sadoff MM, Guerrette S, Overhauser J, Fishel R (November 1998). "Human exonuclease I interacts with the mismatch repair protein hMSH2". Cancer Res. 58 (20): 4537–42. PMID 9788596.
^ ab"Entrez Gene: EXO1 exonuclease 1".
^Qiu J, Qian Y, Chen V, Guan MX, Shen B (June 1999). "Human exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidance". J. Biol. Chem. 274 (25): 17893–900. doi:10.1074/jbc.274.25.17893. PMID 10364235.
Exonuclease1 is an enzyme that in humans is encoded by the EXO1 gene. This gene encodes a protein with 5' to 3' exonuclease activity as well as RNase...
Exonucleases are enzymes that work by cleaving nucleotides one at a time from the end (exo) of a polynucleotide chain. A hydrolyzing reaction that breaks...
prime repair exonuclease1 is an enzyme that in humans is encoded by the TREX1 gene. This gene encodes the major 3'->5' DNA exonuclease in human cells...
Exonuclease 5 is a protein that in humans is encoded by the EXO5 gene. The protein encoded by this gene is a single-stranded DNA (ssDNA)-specific exonuclease...
Exonuclease III (ExoIII) is an enzyme that belongs to the exonuclease family. ExoIII catalyzes the stepwise removal of mononucleotides from 3´-hydroxyl...
prime repair exonuclease1". The normal function of the TREX1 gene is to provide instructions for making the 3-prime repair exonuclease1 enzyme. This...
strand to be excised as it goes. An exonuclease trails the complex and digests the ss-DNA tail. The exonuclease recruited is dependent on which side...
3' to 5' exonuclease proofreading activity resulting in relatively low replication fidelity. Originally its error rate was measured at about 1 in 9,000...
Venom exonuclease (EC 3.1.15.1, venom phosphodiesterase) is an enzyme. This enzyme catalyses the following chemical reaction Exonucleolytic cleavage in...
genomic retroelements by the three prime repair exonuclease1 (TREX1) and excision repair cross complementing 1 (ERCC) appear to mimic the action of RM-systems...
Mitochondrial genome maintenance exonuclease1, abbreviated as MGME1, is an enzyme that in humans is encoded by the MGME1 gene. MGME1 is a 344 amino acids...
genomic retroelements by the three prime repair exonuclease1 (TREX1) and excision repair cross complementing 1(ERCC) appear to mimic the action of RM-systems...
syndrome. MLH1 has been shown to interact with: Bloom syndrome protein Exonuclease1, MBD4, MSH4, Myc, and PMS2. Mismatch repair#MutH: an endonuclease present...
activity and the 3’ → 5’ exonuclease activity for removal of precoding nucleotides and proofreading, but loses its 5' → 3' exonuclease activity. The other...
recognized, DNA polymerase moves backwards by one base pair of DNA. The 3'–5' exonuclease activity of the enzyme allows the incorrect base pair to be excised (this...
Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known by their taxonomic names Human alphaherpesvirus 1 and Human alphaherpesvirus 2, are two members...
Ozsoy AZ, Genschel J, Modrich P, Kowalczykowski SC (2008). "Human exonuclease1 and BLM helicase interact to resect DNA and initiate DNA repair". Proc...
Exodeoxyribonuclease I (EC 3.1.11.1, Escherichia coli exonuclease I, E. coli exonuclease I, exonuclease I) is an enzyme that catalyses the following chemical...
Exodeoxyribonuclease III (EC 3.1.11.2, Escherichia coli exonuclease III, E. coli exonuclease III, endoribonuclease III) is an enzyme that catalyses the...
a template strand A 3'→5' (reverse) exonuclease activity that mediates proofreading A 5'→3' (forward) exonuclease activity mediating nick translation...
Jiricny J (September 2015). "FANCD2-associated nuclease 1, but not exonuclease1 or flap endonuclease 1, is able to unhook DNA interstrand cross-links in vitro"...
on by cold. A missense mutation in TREX1, encoding the 3′–5′ repair exonuclease1, was found in affected individuals of one kindred in familial CHLE with...
DIS3-like exonuclease1 (Dis3L1 or Dis3L) is an enzyme that in humans is encoded by the DIS3L gene. Its protein product is an RNase enzyme homologous...
components. The three required enzyme activities are: exonuclease, DNA polymerase, and DNA ligase. The exonuclease chews back DNA from the 5' end, thus not inhibiting...
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