Spleen exonuclease (EC 3.1.16.1, 3'-exonuclease, spleen phosphodiesterase, 3'-nucleotide phosphodiesterase, phosphodiesterase II) is an enzyme.[1] This enzyme catalyses the following chemical reaction
Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 3'-phosphates (exonuclease type b)
This enzyme has a preference for single-stranded substrate.
PLD3 and/or PLD4 might be the genes encoding spleen exonuclease, as they have similar substrate specificity and tissue distribution.[2]
^Bernardi A, Bernardi G (1971). "Spleen acid nuclease". In Boyer PD (ed.). The Enzymes. Vol. 4 (3rd ed.). New York: Academic Press. pp. 329–336.
^Gavin AL, Huang D, Huber C, Mårtensson A, Tardif V, Skog PD, et al. (September 2018). "PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing". Nature Immunology. 19 (9): 942–953. doi:10.1038/s41590-018-0179-y. PMC 6105523. PMID 30111894.
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Spleenexonuclease (EC 3.1.16.1, 3'-exonuclease, spleen phosphodiesterase, 3'-nucleotide phosphodiesterase, phosphodiesterase II) is an enzyme. This enzyme...
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