Exodeoxyribonuclease III (EC 3.1.11.2, Escherichia coli exonuclease III, E. coli exonuclease III, endoribonuclease III) is an enzyme[1][2][3] that catalyses the following reaction
Exonucleolytic cleavage in the 3′- to 5′-direction to yield nucleoside 5′-phosphates
This enzyme has a preference for double-stranded DNA.
^Lindahl T, Gally JA, Edelman GM (September 1969). "Properties of deoxyribonuclease 3 from mammalian tissues". The Journal of Biological Chemistry. 244 (18): 5014–9. doi:10.1016/S0021-9258(18)94303-6. PMID 5824576.
^Richardson CC, Kornberg A (January 1964). "A deoxyribonucleic acid phosphatase-exonuclease from Escherichia coli. I. Purification of the enzyme and characterization of the phosphatase activity". The Journal of Biological Chemistry. 239: 242–50. doi:10.1016/S0021-9258(18)51774-9. PMID 14114850.
^Richardson CC, Lehman IR, Kornberg A (January 1964). "A deoxyribonucleic acid phosphatase-exonuclease from Escherichia coli. II. Characterization of the exonuclease activity". The Journal of Biological Chemistry. 239: 251–8. doi:10.1016/S0021-9258(18)51775-0. PMID 14114851.
and 10 Related for: Exodeoxyribonuclease III information
ExodeoxyribonucleaseIII (EC 3.1.11.2, Escherichia coli exonuclease III, E. coli exonuclease III, endoribonuclease III) is an enzyme that catalyses the...
coli protein suggests that this enzyme may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity. Mutations in this gene...
synthesis in a 5' → 3' manner. Exonuclease III has four catalytic activities: 3' to 5' exodeoxyribonuclease activity, which is specific for double-stranded...
Biotechnology Information, U.S. National Library of Medicine. Wilson DM III, Carney JP, Coleman MA, Adamson AW, Christensen M, Lamerdin JE (September...
structure of human APEX nuclease homologous to Escherichia coli exonuclease III". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1131...
(1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis...
separate patient (p.R507C). This variant is located in the highly conserved ExoIII domain and has not been completely characterized as yet. POLD1 Ser605del...
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