Global InformationChilblain lupus erythematosus information
| Chilblain lupus erythematosus | |
|---|---|
| Other names | Chilblain lupus erythematosus of Hutchinson, Chilblain lupus, CHLE, Hutchinson lupus.[1] |
| Specialty | Dermatology  |
Chilblain lupus erythematosus was initially described by Hutchinson in 1888 as an uncommon manifestation of chronic cutaneous lupus erythematosus.[2] Chilblain lupus erythematosus is characterized by a rash that primarily affects acral surfaces that are frequently exposed to cold temperatures, such as the toes, fingers, ears, and nose. The rash is defined by oedematous skin, nodules, and tender plaques with a purple discoloration.[3]
Its pathogenetic factors include cold-induced vascular thrombosis, blood stasis, and impaired microcirculation.[4] Chilblain lupus has been linked to anti-Ro antibodies.[5]
- ^ "Chilblain lupus". Monarch Initiative. Retrieved December 25, 2023.
- ^ Hutchinson, J. (January 14, 1888). "Harveian Lectures on Lupus". BMJ. 1 (1411): 58–63. doi:10.1136/bmj.1.1411.58. ISSN 0959-8138. PMC 2197256. PMID 20752140.
- ^ AlMahameed, Amjad; Pinto, Duane S. (March 29, 2008). "Pernio (Chilblains)". Current Treatment Options in Cardiovascular Medicine. 10 (2). Springer Science and Business Media LLC: 128–135. doi:10.1007/s11936-008-0014-0. ISSN 1092-8464. PMID 18325315. S2CID 32207202.
- ^ Doutre, M.S.; Beylot, C.; Beylot, J.; Pompougnac, E.; Royer, P. (1992). "Chilblain Lupus erythematosus: Report of 15 Cases". Dermatology. 184 (1). S. Karger AG: 26–28. doi:10.1159/000247494. ISSN 1018-8665. PMID 1558991.
- ^ Franceschini, F; Calzavara-Pinton, P; Quinzanini, M; Cavazzana, I; Bettoni, L; Zane, C; Facchetti, F; Airò, P; McCauliffe, D P; Cattaneo, R (1999). "Chilblain lupus erythematosus is associated with antibodies to SSA/Ro". Lupus. 8 (3). SAGE Publications: 215–219. doi:10.1191/096120399678847632. ISSN 0961-2033. PMID 10342714. S2CID 40390076.