crystal structure of exodeoxyribonuclease vii small subunit (np_881400.1) from bordetella pertussis at 2.40 a resolution
Identifiers
Symbol
Exonuc_VII_S
Pfam
PF02609
InterPro
IPR003761
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
The enzyme exodeoxyribonuclease VII (EC 3.1.11.6, Escherichia coli exonuclease VII, E. coli exonuclease VII, endodeoxyribonuclease VII, exodeoxyribonuclease VII) is a bacterial exonuclease enzyme.[1][2] It is composed of two nonidentical subunits; one large subunit and 4 small ones.[3] that catalyses exonucleolytic cleavage in either 5′- to 3′- or 3′- to 5′-direction to yield nucleoside 5′-phosphates. The large subunit also contains an N-terminal OB-fold domain that binds to nucleic acids.
^Chase, J.W.; Richardson, C.C. (1974). "Ribonuclease VII of Escherichia coli". J. Biol. Chem. 249 (14): 4545–4552. doi:10.1016/S0021-9258(19)42453-8. PMID 4602029.
^Chase, J.W.; Richardson, C.C. (1974). "Exonuclease VII of Escherichia coli". J. Biol. Chem. 249 (14): 4553–4561. doi:10.1016/S0021-9258(19)42454-X. PMID 4602030.
exodeoxyribonuclease VII (EC 3.1.11.6, Escherichia coli exonucleaseVII, E. coli exonucleaseVII, endodeoxyribonuclease VII, exodeoxyribonuclease VII) is a bacterial...
Exonucleases are enzymes that work by cleaving nucleotides one at a time from the end (exo) of a polynucleotide chain. A hydrolyzing reaction that breaks...
insertion in major sigma factor 70, and a one-amino-acid deletion in exonucleaseVII. These indels are all characteristic of the genus and serve as molecular...
protein and the major sigma factor 70, and a one-amino-acid deletion in exonucleaseVII protein that are specific for the Rickettsiaceae species have been...
back-to-back with the xseA promoter (encoding the mismatch repair enzyme exonucleaseVII). Such close spacing of promoters may have regulatory significance...
recognized, DNA polymerase moves backwards by one base pair of DNA. The 3'–5' exonuclease activity of the enzyme allows the incorrect base pair to be excised (this...
by MutH is on the 5' end of the mismatch, either RecJ or ExoVII (both 5' to 3' exonucleases) is used. If, however, the nick is on the 3' end of the mismatch...
mismatched thymine (underlined in the previous sequence). One of the exonucleases RecJ, ExoVII, or ExoI then degrades the site before DNA polymerase resynthesizes...
background due to non-specific cleavage. Surveyor nuclease also has a 5′ exonuclease activity that attacks the ends of double‐stranded DNA increasing background...
EGFR-coamplified and overexpressed protein EEPD1: encoding protein Endonuclease/exonuclease/phosphatase family domain containing 1 EGFR-AS1: encoding protein EGFR...
selectively cleave the unmethylated daughter strand, allowing helicase and exonucleases to excise the nascent strand in the region surrounding the mismatch....
Global Information