Cloniprazepam information

Cloniprazepam
Clinical data
Other names	1-Cyclopropylmethylclonazepam, Kloniprazepam, 2-Chloro-7'-nitroprazepam
Drug class	Benzodiazepines
Legal status
Legal status	CA: Schedule IV; DE: NpSG (Industrial and scientific use only); UK: Under Psychoactive Substances Act;
Identifiers
	IUPAC name 5-(2-Chlorophenyl)-1-(cyclopropylmethyl)-7-nitro-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one;
CAS Number	1998158-84-1 ;
PubChem CID	137700140;
ChemSpider	68003855;
UNII	YSL4SM8QYP;
CompTox Dashboard (EPA)	DTXSID60893511 ;
Chemical and physical data
Formula	C19H16ClN3O3
Molar mass	369.81 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1N(CC2CC2)C3=CC=C([N+]([O-])=O)C=C3C(C4=CC=CC=C4Cl)=NC1;
	InChI InChI=1S/C19H16ClN3O3/c20-16-4-2-1-3-14(16)19-15-9-13(23(25)26)7-8-17(15)22(11-12-5-6-12)18(24)10-21-19/h1-4,7-9,12H,5-6,10-11H2; Key:CCSYKGYLSFXNTA-UHFFFAOYSA-N;

Cloniprazepam is a benzodiazepine derivative and a prodrug of clonazepam, 7-aminoclonazepam, and other metabolites.^[1]^[2]

Some of the minor metabolites include 3-hydroxyclonazepam and 6-hydroxyclonazepam, 3-hydroxycloniprazepam and ketocloniprazepam with ketone group formed where 3-hydroxy group was.^[1]

It is a designer drug and an NPS (short for "new psychoactive substance").^[1] At the end of 2017, cloniprazepam was an uncontrolled substance in most of the countries.

^ ^a ^b ^c Moosmann B, Bisel P, Franz F, Huppertz LM, Auwärter V (November 2016). "Characterization and in vitro phase I microsomal metabolism of designer benzodiazepines - an update comprising adinazolam, cloniprazepam, fonazepam, 3-hydroxyphenazepam, metizolam and nitrazolam". Journal of Mass Spectrometry. 51 (11): 1080–1089. Bibcode:2016JMSp...51.1080M. doi:10.1002/jms.3840. PMID 27535017.
^ Mortelé O, Vervliet P, Gys C, Degreef M, Cuykx M, Maudens K, et al. (May 2018). "In vitro Phase I and Phase II metabolism of the new designer benzodiazepine cloniprazepam using liquid chromatography coupled to quadrupole time-of-flight mass spectrometry". Journal of Pharmaceutical and Biomedical Analysis. 153: 158–167. doi:10.1016/j.jpba.2018.02.032. hdl:10067/1496330151162165141. PMID 29494888. S2CID 3946404.

[pmid27535017-1] Moosmann B, Bisel P, Franz F, Huppertz LM, Auwärter V (November 2016). "Characterization and in vitro phase I microsomal metabolism of designer benzodiazepines - an update comprising adinazolam, cloniprazepam, fonazepam, 3-hydroxyphenazepam, metizolam and nitrazolam". Journal of Mass Spectrometry. 51 (11): 1080–1089. Bibcode:2016JMSp...51.1080M. doi:10.1002/jms.3840. PMID 27535017.

[2] Mortelé O, Vervliet P, Gys C, Degreef M, Cuykx M, Maudens K, et al. (May 2018). "In vitro Phase I and Phase II metabolism of the new designer benzodiazepine cloniprazepam using liquid chromatography coupled to quadrupole time-of-flight mass spectrometry". Journal of Pharmaceutical and Biomedical Analysis. 153: 158–167. doi:10.1016/j.jpba.2018.02.032. hdl:10067/1496330151162165141. PMID 29494888. S2CID 3946404.

Cloniprazepam information

and 28 Related for: Cloniprazepam information

Cloniprazepam

Nitrous oxide

Methaqualone

Butane

Pentobarbital

Nicotinamide

Dihydrotestosterone

Cholesterol

Acetone

Kava

Chloroform

Zolpidem

Ethchlorvynol

Benzodiazepine

Lorazepam

Alprazolam

Isopropyl alcohol

Toluene

Propane

Phenobarbital

Propofol

Methanol

Barbiturate

Fluoxetine

Clonazepam

Temazepam

Nonbenzodiazepine

Flunitrazepam