Temazepam, sold under the brand name Restoril among others, is a medication of the benzodiazepine class which is generally used to treat severe or debilitating insomnia.[8] It is taken by mouth.[8] Temazepam is rapidly absorbed, and significant hypnotic effects begin in less than 30 minutes and can last for up to eight hours.[9][7] Prescriptions for hypnotics such as temazepam have seen a dramatic decrease since 2010, while anxiolytics such as alprazolam, clonazepam, and lorazepam have increased or remained stable.[10] Temazepam and similar hypnotics, such as triazolam (Halcion) are generally reserved for severe and debilitating insomnia. They have largely been replaced by z-drugs (zopiclone, zolpidem) and atypical antidepressants (trazodone, mirtazapine) as first line treatment for insomnia.[8]
Common side effects include drowsiness, motor and cognitive impairment, lethargy, confusion, euphoria, and dizziness.[8] Serious side effects may include hallucinations, hypotension, respiratory depression, abuse, anaphylaxis, and suicide.[8] Use is generally not recommended together with alcohol or opioids.[8] If the dose is rapidly decreased withdrawal may occur.[8] Use during pregnancy or breastfeeding is not recommended.[11] Temazepam is a short-acting benzodiazepine and hypnotic.[8][7] It works by affecting GABA within the brain.[8]
Temazepam was patented in 1962 and came into medical use in 1969.[12] It is available as a generic medication.[13] In 2021, it was the 208th most commonly prescribed medication in the United States, with more than 2million prescriptions.[14][15]
^"Temazepam". www.drugbank.ca. Retrieved 26 June 2019.
^Temaze temazepam 10mg tablet bottle (63863)
^Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
^"Temazepam Product information". Health Canada. 25 April 2012. Retrieved 20 October 2022.
^"Temazepam 10mg/5ml Oral Solution - Summary of Product Characteristics (SmPC)". (emc). 9 April 2021. Retrieved 20 October 2022.
^"Restoril- temazepam capsule". DailyMed. 11 February 2021. Retrieved 20 October 2022.
^ abcCollins SR (2015). Pharmacology and the Nursing Process. Elsevier Health Sciences. p. 193. ISBN 9780323358286.
^ abcdefghi"Temazepam Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 8 April 2019.
^Cite error: The named reference monograph was invoked but never defined (see the help page).
^Breen CL, Degenhardt LJ, Bruno RB, Roxburgh AD, Jenkinson R (September 2004). "The effects of restricting publicly subsidised temazepam capsules on benzodiazepine use among injecting drug users in Australia". The Medical Journal of Australia. 181 (6): 300–304. doi:10.5694/j.1326-5377.2004.tb06293.x. PMID 15377238. S2CID 6870892.
^"Temazepam (Restoril) Use During Pregnancy". Drugs.com. Retrieved 8 April 2019.
^Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 537. ISBN 9783527607495.
^British national formulary: BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 481. ISBN 9780857113382.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Temazepam - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
Temazepam, sold under the brand name Restoril among others, is a medication of the benzodiazepine class which is generally used to treat severe or debilitating...
poisonings have been attributed to benzodiazepines with or without alcohol. Temazepam was shown to be more toxic than the majority of benzodiazepines. An Australian...
than 20 mg of temazepam, are all placed on List 2 of the Opium Law. A prescription is needed for possession of all benzodiazepines. Temazepam formulations...
Farmaceutici Riuniti SpA in the mid-1970s. It is the fluorinated analogue of temazepam that has powerful hypnotic, sedative, amnesiac, anxiolytic, anticonvulsant...
suggesting a higher abuse potential of these drugs. In neighboring Finland, temazepam accounts for roughly 40–50% benzodiazepine prescription forgeries annually...
the drug internationally. Many clandestine temazepam labs are in Eastern Europe. The labs manufacture temazepam by chemically altering diazepam, oxazepam...
nickname or surname Gelignite, also known as blasting jelly or simply jelly Temazepam, a powerful hypnotic drug, street name "jellies" Jellyfish, also known...
performance impact duration were melatonin (with no impact), zaleplon, temazepam, and zopiclone. The effects on serial reaction time (SRT), logical reasoning...
alcohol withdrawal syndrome. It is a metabolite of diazepam, prazepam, and temazepam, and has moderate amnesic, anxiolytic, anticonvulsant, hypnotic, sedative...
that Goddard died from an accidental drug overdose of heroin, cocaine, temazepam and vicodin. "Trevor Goddard, 37, Actor; Left Boxing for TV and Films"...
names Albego, Limpidon and Paxor. It is the dimethyl carbamate ester of temazepam, a metabolite of diazepam. While it possesses anxiolytic, anticonvulsant...
was never marketed. It is the 7-nitro instead of 7-chloro analogue of temazepam, and also the 3-hydroxy derivative of nimetazepam, and an active metabolite...
short to intermediate acting 3-hydroxy benzodiazepine derivative and temazepam analogue. It possesses hypnotic, anxiolytic, anticonvulsant, sedative...
concentrations of diazepam and its metabolites desmethyldiazepam, oxazepam, and temazepam, according to samples taken in the hospital and as follow-up. Overdoses...
steroids Elderly ↑ or unchanged No change found for paracetamol, oxazepam, temazepam, or propranolol. Decreased clearance found for codeine-6-glucuronide,...
chlordiazepoxide, lorazepam, triazolam. A 1985 study found that triazolam and temazepam maintained higher rates of self-injection in both human and animal subjects...
Lancaume died by suicide on 28 January 2005, by taking an overdose of temazepam and alcohol, in her ex-boyfriend's apartment in Paris, France. She was...
maintenance of anesthesia, as well as a benzodiazepine (usually midazolam, but temazepam or flunitrazepam are also used via the oral route) and a narcotic/systemic...
to his grandmother's home. He would drug his victim with triazolam or temazepam before or shortly after engaging in sexual activity with them. Once his...
0.5 mg was shown to be superior to flurazepam 30 mg, but inferior to temazepam 30 mg in some studies. Brotizolam at dosages below 0.5 mg at night usually...
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