Lorazepam, sold under the brand name Ativan among others, is a benzodiazepine medication.[7] It is used to treat anxiety (including anxiety disorders), trouble sleeping, severe agitation, active seizures including status epilepticus, alcohol withdrawal, and chemotherapy-induced nausea and vomiting.[7] It is also used during surgery to interfere with memory formation and to sedate those who are being mechanically ventilated.[7][11] It is also used, along with other treatments, for acute coronary syndrome due to cocaine use.[7] It can be given orally (by mouth), transdermal (on the skin via a topical gel or patch), intravenously (IV) (injection into a vein), or intramuscularly (injection into a muscle.)[7] When given by injection, onset of effects is between one and thirty minutes and effects last for up to a day.[7]
Common side effects include weakness, sleepiness, low blood pressure, and a decreased effort to breathe.[7] When given intravenously, the person should be closely monitored.[7] Among those who are depressed, there may be an increased risk of suicide.[7][12] With long-term use, larger doses may be required for the same effect.[7] Physical dependence and psychological dependence may also occur.[7] If stopped suddenly after long-term use, benzodiazepine withdrawal syndrome may occur.[7] Older people more often develop adverse effects.[13] In this age group, lorazepam is associated with falls and hip fractures.[14] Due to these concerns, lorazepam use is generally only recommended for up to two to four weeks.[15]
Lorazepam was initially patented in 1963 and went on sale in the United States in 1977.[16][17] It is on the World Health Organization's List of Essential Medicines.[18] It is available as a generic medication.[7] In 2021, it was the 78th most commonly prescribed medication in the United States, with more than 8million prescriptions.[19][20]
^"Lorazepam". The Drug Gene Interaction Database. Archived from the original on 5 August 2016. Retrieved 18 May 2016.
^Edmunds M, Mayhew M (2013). Pharmacology for the Primary Care Provider (4th ed.). Mosby. p. 545. ISBN 978-0-323-08790-2. Archived from the original on 14 January 2023. Retrieved 13 July 2020.
^Clinical Addiction Psychiatry. Cambridge University Press. 2010. p. 156. ISBN 978-1-139-49169-3. Archived from the original on 8 September 2017.
^Ries RK (2009). Principles of addiction medicine (4 ed.). Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins. p. 106. ISBN 978-0-7817-7477-2. Archived from the original on 8 September 2017.
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
^ abcdefghijklmno"Lorazepam". drugs.com. American Society of Health-System Pharmacists. 29 June 2016. Archived from the original on 5 June 2016. Retrieved 15 July 2016.
^Greenblatt DJ, Shader RI, Franke K, Maclaughlin DS, Harmatz JS, Allen MD, Werner A, Woo E (1991). "Pharmacokinetics and bioavailability of intravenous, intramuscular, and oral lorazepam in humans". Journal of Pharmaceutical Sciences. 68 (1): 57–63. doi:10.1002/jps.2600680119. PMID 31453.
^Greenblatt DJ, von Moltke LL, Ehrenberg BL, Harmatz JS, Corbett KE, Wallace DW, Shader RI (2000). "Kinetics and dynamics of lorazepam during and after continuous intravenous infusion". Critical Care Medicine. 28 (8): 2750–2757. doi:10.1097/00003246-200008000-00011. PMID 10966246. S2CID 42138460.
^Papini O, da Cunha SP, da Silva Mathes Ado C, Bertucci C, Moisés EC, de Barros Duarte L, de Carvalho Cavalli R, Lanchote VL (2006). "Kinetic disposition of lorazepam with a focus on the glucuronidation capacity, transplacental transfer in parturients and racemization in biological samples". Journal of Pharmaceutical and Biomedical Analysis. 40 (2): 397–403. doi:10.1016/j.jpba.2005.07.021. PMID 16143486.
^"Lorazepam: MedlinePlus Drug Information". medlineplus.gov. 1 October 2010. Archived from the original on 19 August 2016. Retrieved 16 July 2016.
^Dodds TJ (March 2017). "Prescribed Benzodiazepines and Suicide Risk: A Review of the Literature". The Primary Care Companion for CNS Disorders. 19 (2). doi:10.4088/PCC.16r02037. PMID 28257172.
^Riss J, Cloyd J, Gates J, Collins S (2008). "Benzodiazepines in epilepsy: pharmacology and pharmacokinetics". Acta Neurologica Scandinavica. 118 (2): 69–86. doi:10.1111/j.1600-0404.2008.01004.x. PMID 18384456. S2CID 24453988.
^Mets MA, Volkerts ER, Olivier B, Verster JC (2010). "Effect of hypnotic drugs on body balance and standing steadiness". Sleep Medicine Reviews. 14 (4): 259–267. doi:10.1016/j.smrv.2009.10.008. PMID 20171127.
^"Ativan (lorazepam) Tablets Rx only" (PDF). Food and Drug Administration. March 2007. Archived (PDF) from the original on 17 September 2011. In general, benzodiazepines should be prescribed for short periods only (e.g. 2–4 weeks). Extension of the treatment period should not take place without reevaluation of the need for continued therapy. Continuous long-term use of product is not recommended.
^Shorter E (2005). "B". A Historical Dictionary of Psychiatry. Oxford University Press. ISBN 978-0-19-029201-0. Archived from the original on 28 March 2017.
^US patent 3296249, Stanley C. Bell, "5-monocyclic aryl-1, 3-dihydro-2h-1, 4-benzodiazepin-2-ones", published 1967-01-03, issued 1967-01-03, assigned to American Home Products
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Lorazepam - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
Lorazepam, sold under the brand name Ativan among others, is a benzodiazepine medication. It is used to treat anxiety (including anxiety disorders), trouble...
she had died by asphyxiation, and had been given at least twenty-seven lorazepam pills on the day of her death, more than nine times a high dosage amount...
patient responds to the lorazepam challenge, then lorazepam can be scheduled at interval doses until the catatonia resolves. The lorazepam must be tapered slowly...
isoflurane, diethyl ether, propofol, etomidate, ketamine, pentobarbital, lorazepam and midazolam. Sedation is typically used in minor surgical procedures...
it has a longer half-life than lorazepam) is that studies have found that benzodiazepines like midazolam and lorazepam tend to accumulate in critically...
typically phenytoin is given. Possible benzodiazepines include intravenous lorazepam as well as intramuscular injections of midazolam. A number of other medications...
had not received lorazepam. However, the lorazepam participants produced more incorrect recall responses to their TOT states. Lorazepam may inhibit the...
greatly reduced abuse potential. Studies comparing it to the benzodiazepine lorazepam and the antihistamine diphenhydramine, along with placebo, find that methocarbamol...
solubility, which reduces pain upon injection. Diazepam and lorazepam are sometimes used. Lorazepam has particularly marked amnesic properties that may make...
to produce fewer withdrawal reactions than alprazolam, temazepam, or lorazepam. Factors that determine the risk of psychological dependence or physical...
Dadumir) and chloroxazepam (also known as lorazepam, trade name Ativan). Benzodiazepine Delorazepam Lorazepam DE Patent 1954065 "Benzodiazepine Names"...
not enough, medications are also often used. Intramuscular midazolam, lorazepam, or another benzodiazepine can be used both to sedate agitated patients...
decrease since 2010, while anxiolytics such as alprazolam, clonazepam, and lorazepam have increased or remained stable. Temazepam and similar hypnotics, such...
elimination half-life; showing superiority over the short-acting drug lorazepam. In comparison with the antidepressant drugs, paroxetine and imipramine...
have. Intravenous diazepam or lorazepam are first-line treatments for status epilepticus. However, intravenous lorazepam has advantages over intravenous...
at 2:26 pm Pacific time (21:26 UTC). Murray had administered propofol, lorazepam, and midazolam; his death was caused by a propofol overdose. News of his...
Jackson had been administered propofol and anti-anxiety benzodiazepines lorazepam and midazolam by his doctor. Murray was convicted of involuntary manslaughter...
other classical benzodiazepines include: diazepam, clonazepam, oxazepam, lorazepam, nitrazepam, flurazepam, and clorazepate. Its molecular structure is composed...
she needed him to take care of Asunta; Rosario prepares an overdose of lorazepam and dissolves it in orange juice but gives it to Asunta when she asks...
recommended. Benzodiazepines are the medication of choice with diazepam, lorazepam, chlordiazepoxide, and oxazepam all commonly used. They should be given...
concentrations in females Males ↑ Body habitus Overweight ↑ Clearance of lorazepam, oxazepam, temazepam, and paracetamol likely the result of an increase...
early stages, treating psychiatric symptoms. Benzodiazepines, such as lorazepam, are the drugs of choice to control agitation and seizures (when present)...