Cardiomyocyte proliferation refers to the ability of cardiac muscle cells to progress through the cell cycle and continue to divide. Traditionally, cardiomyocytes were believed to have little to no ability to proliferate and regenerate after birth.[1] Although other types of cells, such as gastrointestinal epithelial cells, can proliferate and differentiate throughout life,[2] cardiac tissue contains little intrinsic ability to proliferate, as adult human cells arrest in the cell cycle.[3] However, a recent paradigm shift has occurred. Recent research has demonstrated that human cardiomyocytes do proliferate to a small extent for the first two decades of life.[4] Also, cardiomyocyte proliferation and regeneration has been demonstrated to occur in various neonatal mammals in response to injury in the first week of life.[5][6] Current research aims to further understand the biological mechanism underlying cardiomyocyte proliferation in hopes to turn this capability back on in adults in order to combat heart disease.
^Sadek H, Olson EN (2020). "Toward the goal of human heart regeneration". Cell Stem Cell. 26 (1): 7–16. doi:10.1016/j.stem.2019.12.004. PMC 7257208. PMID 31901252.
^Mollova M, Bersell K, Walsh S, Salva J, Das LT, Park SY, Kühn B (2013). "Cardiomyocyte proliferation contributes to heart growth in young humans". Proceedings of the National Academy of Sciences. 110 (4): 1446–1451. Bibcode:2013PNAS..110.1446M. doi:10.1073/pnas.1214608110. PMC 3557060. PMID 23302686.
^Porello ER, Mahmoud, AI, Simpson E, Hill JA, Richardson JA, Olson EN, Sadek HA (2011). "Transient regenerative potential of the neonatal mouse heart". Science. 331 (6020): 1078–1080. Bibcode:2011Sci...331.1078P. doi:10.1126/science.1200708. PMC 3099478. PMID 21350179.
Cardiomyocyteproliferation refers to the ability of cardiac muscle cells to progress through the cell cycle and continue to divide. Traditionally, cardiomyocytes...
Sadek, Hesham A. (2015). "Human Ventricular Unloading Induces CardiomyocyteProliferation". Journal of the American College of Cardiology. 65 (9): 892–900...
Research indicates a key role of this pathway in regulation of cardiomyocyteproliferation and heart size. Inactivation of the Hippo pathway or activation...
because it controls other genes that regulate cardiomyocyteproliferation, such as Tbx2 and N-myc1. Cardiomyocytes are the basis for the correct architectural...
Overexpression of the mouse Jarid2 gene has been reported to repress cardiomyocyteproliferation through it close interaction with retinoblastoma protein (Rb)...
upregulated in cardiomyocytes after birth and that LKB1 abundance negatively correlates with proliferation of neonatal rat cardiomyocytes. Loss of LKB1...
and proliferation defects that cause a thin ventricular myocardial compact zone, non-separation of the pulmonary artery and aorta, and cardiomyocyte proliferation...
like nutrient deprivation, that limited the resources necessary for proliferation. Thus it was thought of as a resting phase. G0 is now known to take...
the ventricular wall in a process known as compaction. Cardiomyocyte differentiation, proliferation, and trabeculae patterning is regulated through Notch...
differentiation: iPSCs were differentiated into cardiomyocytes that spontaneously began beating. Cardiomyocytes expressed TnTc, MEF2C, MYL2A, MYHCβ, and NKX2...
development, and small molecule Wnt inhibitors are routinely used to produce cardiomyocytes from pluripotent stem cells. In order to have the mass differentiation...
facilitate development of the stem cells into specific type of cells such as cardiomyocytes. Fibroblasts from different anatomical sites in the body express many...
junction conducts signaling molecules, that influence the differentiation, proliferation and polarity of cells. So tight junction plays a key role in maintenance...
organ or tissue. An example of this is the use of cells to replace cardiomyocytes after myocardial infarction, to facilitate angiogenesis in ischemic...
disc structures, which electrically and mechanically couple adjacent cardiomyocytes. CAR plays an important role in the pathogenesis of myocarditis, dilated...
capable of differentiating into all 3 major cell types of the heart: cardiomyocytes, smooth muscle and endothelial cell lineages. Research has shown that...
broad range of cellular activities, including cell adhesion, migration, proliferation, differentiation, apoptosis, and senescence through interaction with...
salamander. Molecules such as Oncostatin M are considered as a mediator of cardiomyocyte dedifferentiation and morphogenesis factor during myocardial infarction...
zebrafish ventricle regenerates via the proliferation of already differentiated cardiomyocyte. The cardiomyocytes dedifferentiation is observed through...
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