CSNK1D information

CSNK1D
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3UYS, 3UYT, 3UZP, 4HGT, 4HNF, 4KB8, 4KBA, 4KBC, 4KBK, 4TW9, 4TWC, 4TN6, 5IH6, 5IH5, 5IH4
Identifiers
Aliases	CSNK1D, ASPS, CKIdelta, FASPS2, HCKID, casein kinase 1 delta, CKId, CKI-delta
External IDs	OMIM: 600864; MGI: 1355272; HomoloGene: 74841; GeneCards: CSNK1D; OMA:CSNK1D - orthologs
EC number	2.7.11.26
Gene location (Human)
Chr.	Chromosome 17 (human)
End	82,273,700 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	120,882,156 bp
RNA expression pattern
	Top expressed in
	left uterine tube; ; anterior pituitary; ; left lobe of thyroid gland; ; minor salivary glands; ; gastric mucosa; ; right lung; ; right lobe of thyroid gland; ; stromal cell of endometrium; ; upper lobe of left lung; ; canal of the cervix;
	Top expressed in
	Paneth cell; ; fossa; ; condyle; ; retinal pigment epithelium; ; ciliary body; ; motor neuron; ; renal corpuscle; ; trigeminal ganglion; ; medullary collecting duct; ; hair follicle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; peptide binding; kinase activity; tau-protein kinase activity; ATP binding; protein serine/threonine kinase activity; cadherin binding; protein binding;
Cellular component	cytoplasm; cytosol; Golgi apparatus; membrane; plasma membrane; spindle; microtubule organizing center; spindle microtubule; perinuclear region of cytoplasm; neuron projection; endoplasmic reticulum-Golgi intermediate compartment membrane; cytoskeleton; Golgi membrane; nucleus; centrosome; nucleoplasm;
Biological process	cellular response to nerve growth factor stimulus; positive regulation of protein phosphorylation; Golgi organization; phosphorylation; rhythmic process; positive regulation of canonical Wnt signaling pathway; circadian regulation of gene expression; spindle assembly; positive regulation of Wnt signaling pathway; COPII vesicle coating; G2/M transition of mitotic cell cycle; regulation of circadian rhythm; peptidyl-serine phosphorylation; protein localization to cilium; protein localization to Golgi apparatus; protein localization to centrosome; positive regulation of non-canonical Wnt signaling pathway; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; microtubule nucleation; regulation of cell shape; endocytosis; rRNA processing; Wnt signaling pathway; ciliary basal body-plasma membrane docking; positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation; non-motile cilium assembly; protein phosphorylation; regulation of G2/M transition of mitotic cell cycle; peptidyl-threonine phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	1453
	104318
	ENSG00000141551
	ENSMUSG00000025162
	P48730
	Q9DC28
	NM_001893; NM_139062; NM_001363749
	NM_027874; NM_139059
	NP_001884; NP_620693; NP_001350678
	NP_082150; NP_620690
	Wikidata
View/Edit Human	View/Edit Mouse

Casein kinase I isoform delta also known as CKI-delta or CK1δ is an enzyme that in humans is encoded by the gene CSNK1D, which is located on chromosome 17 (17q25.3). It is a member of the CK1 (formerly named casein kinase 1) family of serine/threonine specific eukaryotic protein kinases encompassing seven distinct isoforms (CK1α, γ1-3, δ, ε) as well as various post-transcriptionally processed splice variants (transcription variants, TVs) in mammalians.^[5]^[6]^[7] Meanwhile, CK1δ homologous proteins have been isolated from organisms like yeast, basidiomycetes, plants, algae, and protozoa.^[8]^[9]^[10]^[11]^[12]^[13]^[14]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141551 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025162 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Burzio V, Antonelli M, Allende CC, Allende JE (2002). "Biochemical and cellular characteristics of the four splice variants of protein kinase CK1alpha from zebrafish (Danio rerio)". Journal of Cellular Biochemistry. 86 (4): 805–14. doi:10.1002/jcb.10263. PMID 12210746. S2CID 25667680.
^ Fu Z, Chakraborti T, Morse S, Bennett GS, Shaw G (October 2001). "Four casein kinase I isoforms are differentially partitioned between nucleus and cytoplasm". Experimental Cell Research. 269 (2): 275–86. doi:10.1006/excr.2001.5324. PMID 11570820.
^ Green CL, Bennett GS (August 1998). "Identification of four alternatively spliced isoforms of chicken casein kinase I alpha that are all expressed in diverse cell types". Gene. 216 (1): 189–95. doi:10.1016/S0378-1119(98)00291-1. PMID 9766967.
^ DeMaggio AJ, Lindberg RA, Hunter T, Hoekstra MF (August 1992). "The budding yeast HRR25 gene product is a casein kinase I isoform". Proceedings of the National Academy of Sciences of the United States of America. 89 (15): 7008–12. Bibcode:1992PNAS...89.7008D. doi:10.1073/pnas.89.15.7008. PMC 49634. PMID 1495994.
^ Dhillon N, Hoekstra MF (June 1994). "Characterization of two protein kinases from Schizosaccharomyces pombe involved in the regulation of DNA repair". The EMBO Journal. 13 (12): 2777–88. doi:10.1002/j.1460-2075.1994.tb06571.x. PMC 395157. PMID 8026462.
^ Gross SD, Anderson RA (November 1998). "Casein kinase I: spatial organization and positioning of a multifunctional protein kinase family". Cellular Signalling. 10 (10): 699–711. doi:10.1016/S0898-6568(98)00042-4. PMID 9884021.
^ Kearney PH, Ebert M, Kuret J (August 1994). "Molecular cloning and sequence analysis of two novel fission yeast casein kinase-1 isoforms". Biochemical and Biophysical Research Communications. 203 (1): 231–6. doi:10.1006/bbrc.1994.2172. PMID 8074660.
^ Walczak CE, Anderson RA, Nelson DL (December 1993). "Identification of a family of casein kinases in Paramecium: biochemical characterization and cellular localization". The Biochemical Journal. 296 (3): 729–35. doi:10.1042/bj2960729. PMC 1137756. PMID 8280070.
^ Wang PC, Vancura A, Mitcheson TG, Kuret J (March 1992). "Two genes in Saccharomyces cerevisiae encode a membrane-bound form of casein kinase-1". Molecular Biology of the Cell. 3 (3): 275–86. doi:10.1091/mbc.3.3.275. PMC 275529. PMID 1627830.
^ Wang Y, Liu TB, Patel S, Jiang L, Xue C (November 2011). "The casein kinase I protein Cck1 regulates multiple signaling pathways and is essential for cell integrity and fungal virulence in Cryptococcus neoformans". Eukaryotic Cell. 10 (11): 1455–64. doi:10.1128/EC.05207-11. PMC 3209051. PMID 21926330.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141551 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025162 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Burzio V, Antonelli M, Allende CC, Allende JE (2002). "Biochemical and cellular characteristics of the four splice variants of protein kinase CK1alpha from zebrafish (Danio rerio)". Journal of Cellular Biochemistry. 86 (4): 805–14. doi:10.1002/jcb.10263. PMID 12210746. S2CID 25667680.

[6] Fu Z, Chakraborti T, Morse S, Bennett GS, Shaw G (October 2001). "Four casein kinase I isoforms are differentially partitioned between nucleus and cytoplasm". Experimental Cell Research. 269 (2): 275–86. doi:10.1006/excr.2001.5324. PMID 11570820.

[7] Green CL, Bennett GS (August 1998). "Identification of four alternatively spliced isoforms of chicken casein kinase I alpha that are all expressed in diverse cell types". Gene. 216 (1): 189–95. doi:10.1016/S0378-1119(98)00291-1. PMID 9766967.

[DeMaggio_1992-8] DeMaggio AJ, Lindberg RA, Hunter T, Hoekstra MF (August 1992). "The budding yeast HRR25 gene product is a casein kinase I isoform". Proceedings of the National Academy of Sciences of the United States of America. 89 (15): 7008–12. Bibcode:1992PNAS...89.7008D. doi:10.1073/pnas.89.15.7008. PMC 49634. PMID 1495994.

[9] Dhillon N, Hoekstra MF (June 1994). "Characterization of two protein kinases from Schizosaccharomyces pombe involved in the regulation of DNA repair". The EMBO Journal. 13 (12): 2777–88. doi:10.1002/j.1460-2075.1994.tb06571.x. PMC 395157. PMID 8026462.

[10] Gross SD, Anderson RA (November 1998). "Casein kinase I: spatial organization and positioning of a multifunctional protein kinase family". Cellular Signalling. 10 (10): 699–711. doi:10.1016/S0898-6568(98)00042-4. PMID 9884021.

[11] Kearney PH, Ebert M, Kuret J (August 1994). "Molecular cloning and sequence analysis of two novel fission yeast casein kinase-1 isoforms". Biochemical and Biophysical Research Communications. 203 (1): 231–6. doi:10.1006/bbrc.1994.2172. PMID 8074660.

[12] Walczak CE, Anderson RA, Nelson DL (December 1993). "Identification of a family of casein kinases in Paramecium: biochemical characterization and cellular localization". The Biochemical Journal. 296 (3): 729–35. doi:10.1042/bj2960729. PMC 1137756. PMID 8280070.

[Wang_1992-13] Wang PC, Vancura A, Mitcheson TG, Kuret J (March 1992). "Two genes in Saccharomyces cerevisiae encode a membrane-bound form of casein kinase-1". Molecular Biology of the Cell. 3 (3): 275–86. doi:10.1091/mbc.3.3.275. PMC 275529. PMID 1627830.

[14] Wang Y, Liu TB, Patel S, Jiang L, Xue C (November 2011). "The casein kinase I protein Cck1 regulates multiple signaling pathways and is essential for cell integrity and fungal virulence in Cryptococcus neoformans". Eukaryotic Cell. 10 (11): 1455–64. doi:10.1128/EC.05207-11. PMC 3209051. PMID 21926330.

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