Tight junction proteins (TJ proteins) are molecules situated at the tight junctions of epithelial, endothelial and myelinated cells. This multiprotein junctional complex has a regulatory function in passage of ions, water and solutes through the paracellular pathway. It can also coordinate the motion of lipids and proteins between the apical and basolateral surfaces of the plasma membrane. Thereby tight junction conducts signaling molecules, that influence the differentiation, proliferation and polarity of cells. So tight junction plays a key role in maintenance of osmotic balance and trans-cellular transport of tissue specific molecules. Nowadays is known more than 40 different proteins, that are involved in these selective TJ channels.[1]
proteins composing the tightjunctions. These proteins consist of both transmembrane and cytoplasmic proteins. The three major transmembrane proteins...
belongs to the family of zonula occludens proteins (ZO-1, ZO-2, and ZO-3), which are tightjunction-associated proteins and of which, ZO-1 is the first to be...
Tightjunctionprotein ZO-2 is a protein that in humans is encoded by the TJP2 gene. Tightjunctionproteins (TJPs) belong to a family of membrane-associated...
approximately 40 proteins identified to be involved in tightjunctions. These proteins can be classified into four major categories;signalling proteins. Scaffolding...
at tightjunctions as the molecule adheres to other tightjunctionproteins like PAR-3 and ZO-1. JAM-2 has been shown to interact with these proteins, primarily...
plasma-membrane protein localized at the tightjunctions. Together with Claudins, and zonula occludens-1 (ZO-1), occludin has been considered a staple of tight junctions...
cardiomyocytes. Adherens junctions are composed of the following proteins: cadherins. The cadherins are a family of transmembrane proteins that form homodimers...
to anchoring junctions, intracellular domains of these tightjunctionproteins are bound with scaffold proteins that keep these proteins in clusters and...
kiwifruit, the enzyme is under preliminary research for its effect on tightjunctionproteins of intestinal epithelial cells. Actinidain is commercially useful...
neural crest cells are initially anchored to neighboring cells by tightjunctionproteins such as occludin and cell adhesion molecules such as NCAM and N-Cadherin...
Cormier E, Lavillette D, Cosset FL, Dragic T (Mar 2008). "The TightJunctionProteins Claudin-1, -6, and -9 Are Entry Cofactors for Hepatitis C Virus"...
Claudin-1 is a protein that in humans is encoded by the CLDN1 gene. It belongs to the group of claudins. Tightjunctions represent one mode of cell-to-cell...
family of proteins which, along with occludin, are the most important components of the tightjunctions (zonulae occludentes). Tightjunctions establish...
pathogenesis of syphilis. It does this by reducing the expression of tightjunctionproteins, which in turn increases the expression of adhesion molecules and...
development through controlling the tightjunctionproteins in the blood-testis barrier. While it is a channel protein, GJA1 can also perform channel-independent...
known as CLDN3, is a protein which in humans is encoded by the CLDN3 gene. It is a member of the claudin protein family. Tightjunctions represent one mode...
and source epithelia: barrier function aligns with expression of tightjunctionproteins". Journal of Experimental Biology. 214 (17): 2871–2882. doi:10...
Gap junctionproteins Gap junction α (GJA) proteins GJA1, Cx43, gap junction alpha-1 protein GJA2, Cx38, gap junction alpha-2 protein GJA3, Cx46, gap...
Cormier E, Lavillette D, Cosset FL, Dragic T (Mar 2008). "The tightjunctionproteins claudin-1, -6, and -9 are entry cofactors for hepatitis C virus"...
Several proteins are required for the pedicels to wrap around the capillaries and function. When infants are born with certain defects in these proteins, such...
integrity of the epithelial barrier with expression of their own tight-junctionproteins. A real life example of dendritic cell functions is displayed in...
claudin family. Claudins are integral membrane proteins and components of tightjunction strands. Tightjunction strands serve as a physical barrier to prevent...
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