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Immune system contribution to regeneration information


Immune system contribution to regeneration of tissues generally involves specific cellular components, transcription of a wide variety of genes, morphogenesis, epithelia renewal and proliferation of damaged cell types (progenitor or tissue-resident stem cells). However, current knowledge reveals more and more studies about immune system influence that cannot be omitted. As the immune system exhibits inhibitory or inflammatory functions during regeneration, the therapies are focused on either stopping these processes or control the immune cells setting in a regenerative way, suggesting that interplay between damaged tissue and immune system response must be well-balanced. Recent studies provide evidence that immune components are required not only after body injury but also in homeostasis or senescent cells replacement.

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Immune system contribution to regeneration

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Immune system contribution to regeneration of tissues generally involves specific cellular components, transcription of a wide variety of genes, morphogenesis...

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Immune system

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The immune system is a network of biological systems that protects an organism from diseases. It detects and responds to a wide variety of pathogens, from...

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Transplant rejection

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rejection occurs when transplanted tissue is rejected by the recipient's immune system, which destroys the transplanted tissue. Transplant rejection can be...

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Dermal macrophage

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the exact contribution of each phenotype to cancer defence and the skin's homeostasis is still unclear. Dermal macrophages are native immune cells mainly...

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Regenerative agriculture

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Regenerative agriculture is a conservation and rehabilitation approach to food and farming systems. It focuses on topsoil regeneration, increasing biodiversity...

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Regenerative endodontics

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concept of cell homing in dental pulp and dentin regeneration was first proposed in 2010. In tissue regeneration, cell homing consists of 2 distinct cellular...

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Greater omentum

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omentum are: Fat deposition, having varying amounts of adipose tissue Immune contribution, having milky spots of macrophage collections Infection and wound...

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Progenitor cell

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immune system. Inflammatory cytokines and other factors released during infections will activate haematopoietic progenitor cells to differentiate to replenish...

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Positive feedback

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in the 1920s with the introduction of the regenerative circuit. Friis & Jensen (1924) described regeneration in a set of electronic amplifiers as a case...

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Echinoderm

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echinoderms are able to reproduce asexually and regenerate tissue, organs and limbs; in some cases, they can undergo complete regeneration from a single limb...

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Zebrafish

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used as a model organism to study vertebrate innate immunity. The innate immune system is capable of phagocytic activity by 28 to 30 h postfertilization...

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Denise Faustman

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for regeneration to occur, these cells could hasten regeneration. The source of islet cell regeneration is debated. Faustman's team was the first to document...

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Platelet

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Cox D, Kerrigan SW, Watson SP (June 2011). "Platelets and the innate immune system: mechanisms of bacterial-induced platelet activation". Journal of Thrombosis...

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Microchimerism

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might induce the alteration of the woman's immune system and make the cervical tissue more susceptible to HPV infection or provide a suitable environment...

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Estrogen

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thromboembolism. Estrogen has been shown to upregulate the peptide hormone adropin. The effect of estrogen on the immune system is in general described as Th2 favoring...

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Complement component 4

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intricate complement system, originating from the human leukocyte antigen (HLA) system. It serves a number of critical functions in immunity, tolerance, and...

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Autotomy

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One cost is to the immune system: tail loss results in a weakened immune system which allows for mites and other harmful organisms to have a larger...

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Astrogliosis

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environment conducive to axonal regeneration for about four days. After four days, CNS glia reinvade the area of injection and axonal regeneration is consequently...

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Decellularization

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organ and tissue regeneration. Organ and tissue transplantation treat a variety of medical problems, ranging from end organ failure to cosmetic surgery...

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List of nominees for the Nobel Prize in Physiology or Medicine

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and the discovery of surgical myxoedema" "Contributions to the biochemistry of bacteria; production of immunity by filtered bacterial cultures (hog cholera);...

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T helper 17 cell

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monocytes. Thus, three T helper cell subsets are able to influence the myeloid part of the immune system, largely responsible for innate defense against pathogens...

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Senescence

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PMID 34888528. News article about the study: "Tool that calculates immune system age could predict frailty and disease". New Atlas. 13 July 2021. Archived...

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Neuron

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to neurotrophins such as BDNF. The gut microbiome is also connected with the brain. Neurons also communicate with microglia, the brain's main immune cells...

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Astrocyte

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been described as an impermeable barrier to regeneration, thus implicating a negative role in axon regeneration. However, recently, it was found through...

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