Coxsackievirus and adenovirus receptor information

CXADR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1EAJ, 1F5W, 1JEW, 1KAC, 1P69, 1P6A, 1RSF, 2J12, 2J1K, 2NPL, 2W9L, 2WBW, 3J6L, 3J6M, 3J6N, 3J6O
Identifiers
Aliases	CXADR, CAR, CAR4/6, HCAR, coxsackie virus and adenovirus receptor, Ig-like cell adhesion molecule, CXADR Ig-like cell adhesion molecule
External IDs	OMIM: 602621 MGI: 1201679 HomoloGene: 1024 GeneCards: CXADR
Gene location (Human)
Chr.	Chromosome 21 (human)
End	17,593,579 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	78,156,662 bp
RNA expression pattern
	Top expressed in
	nipple; ; palpebral conjunctiva; ; vulva; ; pylorus; ; jejunal mucosa; ; human penis; ; gums; ; hair follicle; ; corpus epididymis; ; bronchial epithelial cell;
	Top expressed in
	ganglionic eminence; ; epithelium of stomach; ; left colon; ; medial ganglionic eminence; ; parotid gland; ; left lung lobe; ; atrioventricular valve; ; sexually immature organism; ; molar; ; ileum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	PDZ domain binding; beta-catenin binding; connexin binding; virus receptor activity; integrin binding; protein binding; identical protein binding; signaling receptor binding; cell adhesion molecule binding; cell adhesive protein binding involved in AV node cell-bundle of His cell communication;
Cellular component	cytoplasm; integral component of membrane; cell body; membrane; intercalated disc; cell-cell junction; bicellular tight junction; filopodium; growth cone; adherens junction; neuromuscular junction; plasma membrane; integral component of plasma membrane; nucleoplasm; extracellular region; cell junction; apicolateral plasma membrane; basolateral plasma membrane; acrosomal vesicle; membrane raft; neuron projection; extracellular space; protein-containing complex;
Biological process	actin cytoskeleton reorganization; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell junction organization; epithelial structure maintenance; AV node cell to bundle of His cell communication; gamma-delta T cell activation; mitochondrion organization; neutrophil chemotaxis; transepithelial transport; homotypic cell-cell adhesion; heart development; cell adhesion; defense response to virus; regulation of immune response; viral entry into host cell; viral process; leukocyte migration; germ cell migration; AV node cell-bundle of His cell adhesion involved in cell communication; regulation of AV node cell action potential; negative regulation of cardiac muscle cell proliferation; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	1525
	13052
	ENSG00000154639
	ENSMUSG00000022865
	P78310
	P97792
	NM_001207063; NM_001207064; NM_001207065; NM_001207066; NM_001338
	NM_001025192; NM_001276263; NM_009988
	NP_001193992; NP_001193993; NP_001193994; NP_001193995; NP_001329
	NP_001020363; NP_001263192; NP_034118
	Wikidata
View/Edit Human	View/Edit Mouse

Coxsackievirus and adenovirus receptor (CAR) is a protein that in humans is encoded by the CXADR gene.^[5]^[6]^[7] The protein encoded by this gene is a type I membrane receptor for group B coxsackie viruses and subgroup C adenoviruses. CAR protein is expressed in several tissues, including heart, brain, and, more generally, epithelial and endothelial cells. In cardiac muscle, CAR is localized to intercalated disc structures, which electrically and mechanically couple adjacent cardiomyocytes. CAR plays an important role in the pathogenesis of myocarditis, dilated cardiomyopathy, and in arrhythmia susceptibility following myocardial infarction or myocardial ischemia. In addition, an isoform of CAR (CAR-SIV) has been recently identified in the cytoplasm of pancreatic beta cells. It's been suggested that CAR-SIV resides in the insulin secreting granules and might be involved in the virus infection of these cells.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000154639 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022865 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bergelson JM, Cunningham JA, Droguett G, Kurt-Jones EA, Krithivas A, Hong JS, Horwitz MS, Crowell RL, Finberg RW (Feb 1997). "Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5". Science. 275 (5304): 1320–3. doi:10.1126/science.275.5304.1320. PMID 9036860. S2CID 33824689.
^ Tomko RP, Xu R, Philipson L (Apr 1997). "HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses". Proceedings of the National Academy of Sciences of the United States of America. 94 (7): 3352–6. Bibcode:1997PNAS...94.3352T. doi:10.1073/pnas.94.7.3352. PMC 20373. PMID 9096397.
^ "Entrez Gene: CXADR coxsackie virus and adenovirus receptor".
^ Ifie, Eseoghene; Russell, Mark A.; Dhayal, Shalinee; Leete, Pia; Sebastiani, Guido; Nigi, Laura; Dotta, Francesco; Marjomäki, Varpu; Eizirik, Decio L.; Morgan, Noel G.; Richardson, Sarah J. (November 2018). "Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells". Diabetologia. 61 (11): 2344–2355. doi:10.1007/s00125-018-4704-1. ISSN 1432-0428. PMC 6182664. PMID 30074059.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000154639 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022865 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9036860-5] Bergelson JM, Cunningham JA, Droguett G, Kurt-Jones EA, Krithivas A, Hong JS, Horwitz MS, Crowell RL, Finberg RW (Feb 1997). "Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5". Science. 275 (5304): 1320–3. doi:10.1126/science.275.5304.1320. PMID 9036860. S2CID 33824689.

[pmid9096397-6] Tomko RP, Xu R, Philipson L (Apr 1997). "HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses". Proceedings of the National Academy of Sciences of the United States of America. 94 (7): 3352–6. Bibcode:1997PNAS...94.3352T. doi:10.1073/pnas.94.7.3352. PMC 20373. PMID 9096397.

[entrez-7] "Entrez Gene: CXADR coxsackie virus and adenovirus receptor".

[8] Ifie, Eseoghene; Russell, Mark A.; Dhayal, Shalinee; Leete, Pia; Sebastiani, Guido; Nigi, Laura; Dotta, Francesco; Marjomäki, Varpu; Eizirik, Decio L.; Morgan, Noel G.; Richardson, Sarah J. (November 2018). "Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells". Diabetologia. 61 (11): 2344–2355. doi:10.1007/s00125-018-4704-1. ISSN 1432-0428. PMC 6182664. PMID 30074059.

Coxsackievirus and adenovirus receptor information

and 11 Related for: Coxsackievirus and adenovirus receptor information

Coxsackievirus and adenovirus receptor

Coxsackievirus

Adenoviridae

Chromosome 21

Coxsackie B4 virus

MPDZ

LNX1

Tight junction proteins

Myocarditis

Virotherapy

STAT2