CYR61 information

CCN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4D0Z, 4D11
Identifiers
Aliases	CCN1, GIG1, IGFBP10, cysteine rich angiogenic inducer 61, cellular communication network factor 1, CYR61
External IDs	OMIM: 602369; MGI: 88613; HomoloGene: 1194; GeneCards: CCN1; OMA:CCN1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	85,584,589 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	145,355,736 bp
RNA expression pattern
	Top expressed in
	left uterine tube; ; smooth muscle tissue; ; gallbladder; ; vena cava; ; saphenous vein; ; gastric mucosa; ; lower lobe of lung; ; right coronary artery; ; left coronary artery; ; nipple;
	Top expressed in
	endothelial cell of lymphatic vessel; ; stroma of bone marrow; ; calvaria; ; dermis; ; tunica media of zone of aorta; ; muscle of thigh; ; decidua; ; belly cord; ; body of femur; ; right lung;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	insulin-like growth factor binding; growth factor binding; extracellular matrix binding; integrin binding; heparin binding; extracellular matrix structural constituent;
Cellular component	extracellular matrix; extracellular region; extracellular space; endoplasmic reticulum lumen; collagen-containing extracellular matrix;
Biological process	positive regulation of osteoblast proliferation; apoptotic process involved in heart morphogenesis; positive regulation of ceramide biosynthetic process; positive regulation of protein phosphorylation; ventricular septum development; positive regulation of cell migration; anatomical structure morphogenesis; extracellular matrix organization; negative regulation of apoptotic process; labyrinthine layer blood vessel development; reactive oxygen species metabolic process; chorio-allantoic fusion; chondroblast differentiation; chemotaxis; positive regulation of phospholipase activity; atrial septum morphogenesis; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; intussusceptive angiogenesis; positive regulation of osteoblast differentiation; atrioventricular valve morphogenesis; positive regulation of cartilage development; regulation of cell growth; osteoblast differentiation; positive regulation of cell differentiation; regulation of ERK1 and ERK2 cascade; positive regulation of BMP signaling pathway; positive regulation of apoptotic process; cell population proliferation; wound healing, spreading of cells; positive regulation of transcription by RNA polymerase II; positive regulation of protein kinase activity; positive regulation of cell-substrate adhesion; post-translational protein modification; cell adhesion; cell-cell signaling; negative regulation of cell death; cell-cell adhesion; positive regulation of bone mineralization;
	Sources:Amigo / QuickGO
Orthologs
	3491
	16007
	ENSG00000142871
	ENSMUSG00000028195
	O00622
	P18406
	NM_001554
	NM_010516
	NP_001545
	NP_034646
	Wikidata
View/Edit Human	View/Edit Mouse

Cysteine-rich angiogenic inducer 61 (CYR61) or CCN family member 1 (CCN1), is a matricellular protein that in humans is encoded by the CYR61 gene.^[5]

CYR61 is a secreted, extracellular matrix (ECM)-associated signaling protein of the CCN family (CCN intercellular signaling protein).^[6]^[7] CYR61 is capable of regulating a broad range of cellular activities, including cell adhesion, migration, proliferation, differentiation, apoptosis, and senescence through interaction with cell surface integrin receptors and heparan sulfate proteoglycans. During embryonic development, CYR61 is critical for cardiac septal morphogenesis, blood vessel formation in placenta, and vascular integrity. In adulthood CYR61 plays important roles in inflammation and tissue repair, and is associated with diseases related to chronic inflammation, including rheumatoid arthritis, atherosclerosis, diabetes-related nephropathy and retinopathy, and many different forms of cancers.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000142871 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028195 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jay P, Berge-Lefranc JL, Marsollier C, Mejean C, Taviaux S, Berta P (May 1997). "The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p". Oncogene. 14 (14): 1753–7. doi:10.1038/sj.onc.1200986. PMID 9135077.
^ Lau LF (October 2011). "CCN1/CYR61: the very model of a modern matricellular protein". Cell. Mol. Life Sci. 68 (19): 3149–63. doi:10.1007/s00018-011-0778-3. PMC 3651699. PMID 21805345.
^ Jun JI, Lau LF (December 2011). "Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets". Nature Reviews Drug Discovery. 10 (12): 945–63. doi:10.1038/nrd3599. PMC 3663145. PMID 22129992.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000142871 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028195 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9135077-5] Jay P, Berge-Lefranc JL, Marsollier C, Mejean C, Taviaux S, Berta P (May 1997). "The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p". Oncogene. 14 (14): 1753–7. doi:10.1038/sj.onc.1200986. PMID 9135077.

[ReferenceA-6] Lau LF (October 2011). "CCN1/CYR61: the very model of a modern matricellular protein". Cell. Mol. Life Sci. 68 (19): 3149–63. doi:10.1007/s00018-011-0778-3. PMC 3651699. PMID 21805345.

[ReferenceB-7] Jun JI, Lau LF (December 2011). "Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets". Nature Reviews Drug Discovery. 10 (12): 945–63. doi:10.1038/nrd3599. PMC 3663145. PMID 22129992.

CYR61 information

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CYR61

Fibrosis

CTGF

Monocyte

Integrin

CCN1

YAP1

Chromosome 1

CCN

Integrin alpha V

Thrombospondin

CCN protein

Von Willebrand factor type C domain