FOXP1 information

FOXP1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2KIU
Identifiers
Aliases	FOXP1, 12CC4, HSPC215, MFH, QRF1, hFKH1B, forkhead box P1
External IDs	OMIM: 605515; HomoloGene: 136512; GeneCards: FOXP1; OMA:FOXP1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	71,583,978 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; cardia; ; saphenous vein; ; pylorus; ; mucosa of ileum; ; pericardium; ; urethra; ; buccal mucosa cell; ; epithelium of lactiferous gland; ; lactiferous duct;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; sequence-specific DNA binding; protein self-association; androgen receptor binding; DNA-binding transcription factor activity; DNA binding; protein binding; identical protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; chromatin binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; transcription factor binding; protein homodimerization activity; protein heterodimerization activity;
Cellular component	nucleus; nucleoplasm; cytoplasm;
Biological process	regulation of monocyte differentiation; negative regulation of androgen receptor signaling pathway; negative regulation of B cell apoptotic process; positive regulation of endothelial cell migration; transcription, DNA-templated; response to lipopolysaccharide; regulation of defense response to bacterium; endothelial cell activation; regulation of endothelial tube morphogenesis; macrophage activation; osteoclast development; positive regulation of smooth muscle cell proliferation; T follicular helper cell differentiation; regulation of macrophage colony-stimulating factor production; regulation of tumor necrosis factor production; regulation of inflammatory response; osteoclast differentiation; monocyte activation; regulation of transcription, DNA-templated; negative regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; somatic stem cell population maintenance; negative regulation of transcription by RNA polymerase II; in utero embryonic development; positive regulation of mesenchymal cell proliferation; pre-B cell differentiation; positive regulation of immunoglobulin production; heart development; skeletal muscle tissue development; motor neuron axon guidance; ventral spinal cord development; striatum development; lung development; forebrain development; immunoglobulin V(D)J recombination; response to testosterone; sarcomere organization; positive regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; smooth muscle tissue development; positive regulation of epithelial cell proliferation; cardiac muscle cell differentiation; regulation of cardiac muscle cell proliferation; negative regulation of cell growth involved in cardiac muscle cell development; lung secretory cell differentiation; cellular response to tumor necrosis factor; innate vocalization behavior; regulation of action potential; regulation of lung goblet cell differentiation; negative regulation of lung goblet cell differentiation; cellular response to ionomycin; positive regulation of hydrogen peroxide-induced cell death; positive regulation of cardiac muscle cell differentiation; cellular response to DNA damage stimulus; negative regulation of gene expression; positive regulation of B cell receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	27086
	n/a
	ENSG00000114861
	n/a
	Q9H334
	n/a
NM_001012505; NM_001244808; NM_001244810; NM_001244812; NM_001244813;
	NM_001244814; NM_001244815; NM_001244816; NM_032682; NM_001349338; NM_001349340; NM_001349341; NM_001349342; NM_001349343; NM_001349344; NM_001349337; NM_001370548
	n/a
NP_001012523; NP_001231737; NP_001231739; NP_001231741; NP_001231742;
	NP_001231743; NP_001231744; NP_001231745; NP_116071; NP_001336267; NP_001336269; NP_001336270; NP_001336271; NP_001336272; NP_001336273; NP_001336266
	n/a
	Wikidata
View/Edit Human

Forkhead box protein P1 is a protein that in humans is encoded by the FOXP1 gene. FOXP1 is necessary for the proper development of the brain, heart, and lung in mammals. It is a member of the large FOX family of transcription factors.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000114861 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000114861 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

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