myoblast migration involved in skeletal muscle regeneration
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2660
17700
Ensembl
ENSG00000138379
ENSMUSG00000026100
UniProt
O14793
O08689
RefSeq (mRNA)
NM_005259
NM_010834
RefSeq (protein)
NP_005250
NP_034964
Location (UCSC)
Chr 2: 190.06 – 190.06 Mb
Chr 1: 53.1 – 53.11 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
In humans, the MSTN gene is located on the long (q) arm of chromosome 2 at position 32.2.[5]
Myostatin (also known as growth differentiation factor 8, abbreviated GDF8) is a protein that in humans is encoded by the MSTN gene.[6] Myostatin is a myokine that is produced and released by myocytes and acts on muscle cells to inhibit muscle growth.[7] Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.[8][9]
Myostatin is assembled and produced in skeletal muscle before it is released into the blood stream.[10] Most of the data regarding the effects of myostatin comes from studies performed on mice.[11]
Animals either lacking myostatin or treated with substances that block the activity of myostatin have significantly more muscle mass.
Furthermore, individuals who have mutations in both copies of the myostatin gene (popularly, but inaccurately called the "Hercules gene") have significantly more muscle mass and are stronger than normal. There is hope that studies into myostatin may have therapeutic application in treating muscle wasting diseases such as muscular dystrophy.[12]
^ abcGRCh38: Ensembl release 89: ENSG00000138379 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000026100 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"MSTN gene". Genetics Home Reference. 28 March 2016.
^Gonzalez-Cadavid NF, Taylor WE, Yarasheski K, Sinha-Hikim I, Ma K, Ezzat S, et al. (December 1998). "Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting". Proceedings of the National Academy of Sciences of the United States of America. 95 (25): 14938–14943. Bibcode:1998PNAS...9514938G. doi:10.1073/pnas.95.25.14938. PMC 24554. PMID 9843994.
^Saunders MA, Good JM, Lawrence EC, Ferrell RE, Li WH, Nachman MW (December 2006). "Human adaptive evolution at Myostatin (GDF8), a regulator of muscle growth". American Journal of Human Genetics. 79 (6): 1089–1097. doi:10.1086/509707. PMC 1698719. PMID 17186467.
^Carnac G, Ricaud S, Vernus B, Bonnieu A (July 2006). "Myostatin: biology and clinical relevance". Mini Reviews in Medicinal Chemistry. 6 (7): 765–770. doi:10.2174/138955706777698642. PMID 16842126.
^Joulia-Ekaza D, Cabello G (June 2007). "The myostatin gene: physiology and pharmacological relevance". Current Opinion in Pharmacology. 7 (3): 310–315. doi:10.1016/j.coph.2006.11.011. PMID 17374508.
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Myostatin (also known as growth differentiation factor 8, abbreviated GDF8) is a protein that in humans is encoded by the MSTN gene. Myostatin is a myokine...
Myostatin inhibitors are a class of drugs that work by blocking the effects of myostatin, which inhibits muscle growth. In animal models and limited human...
natural mutation in the myostatin gene which codes for the protein, myostatin ("myo" meaning muscle and "statin" meaning stop). Myostatin is a protein that...
identified a natural variant of the myostatin gene found in Limousins which has a significant influence on them. The myostatin gene is found in all mammals and...
the term myokine first occurred in 2003. In 2008, the first myokine, myostatin, was identified. The gp130 receptor cytokine IL-6 (Interleukin 6) was...
Piedmontese cattle carry a unique gene mutation identified as an inactive myostatin allele that causes hypertrophic muscle growth, or double muscling. Purebred...
amount of myostatin portray deficiency in muscle development and increase of fat; on the other hand, smaller than normal amounts of myostatin greatly increase...
naturally occurring gene identified as the myostatin allele mutation, or inactive myostatin gene. Myostatin prohibits muscle growth whereas an inactive...
Stamulumab (MYO-029) is an experimental myostatin inhibiting drug developed by Wyeth Pharmaceuticals for the treatment of muscular dystrophy (MD). Stamulumab...
second leading cause of mortality in Whippets. A 2007 study identified a myostatin mutation particular to Whippets that is significantly associated with...
its role in regulation of muscle growth in mice, as an antagonist to myostatin (also known as GDF-8, a TGF superfamily member) which inhibits excessive...
small interfering RNA. Myostatin is a protein responsible for inhibiting muscle differentiation and growth. Removing the myostatin gene or otherwise limiting...
precursor to myostatin, which limits the size of skeletal muscle tissue, as well as inactive myostatin. It does not bind to active myostatin, activin A...
binds to myostatin, it lowers the amount of myostatin that can bind to the native receptor in the membrane (ActRIIB), preventing myostatin from delivering...
; McPherron, Alexandra C. (October 2011). "Expression and Function of Myostatin in Obesity, Diabetes, and Exercise Adaptation". Medicine and Science in...
receptors regulate muscle growth. Myostatin, a TGF-beta superfamily member, is a negative regulator of muscle growth. Myostatin binds to ACVR2B and to a lesser...
the use of superhuman strength in fiction. Berserker Furor Teutonicus Myostatin Physical strength Hysterical strength Kumar, Rajesh (2010-09-01). "Competing...
total carcass fat—especially seam fat. A mutation in the 3' UTR of the myostatin gene in Texel sheep creates target sites for the microRNAs miR-1 and miR-206...
may refer to: Kocher–Debré–Semelaigne syndrome Adrenogenital syndrome Myostatin mutation resulting in hypertrophy and increased strength This disambiguation...
Edward Stephen Hall (born 15 January 1988) is a British media personality and retired strongman. He is best known for his world-record setting 500 kg (1...
its side effects can be counteracted by the administration of hormones. Myostatin has been used to produce muscle hypertrophy. Sedatives may be administered...
to 1.2 the natural size with the same amount of food due to disabled myostatin, which inhibits muscle growth. Engineering first light of the Vera C....
the natural average size with the same amount of food due to disabled myostatin, which inhibits muscle growth. Creating genetically modified food is a...
to myostatin, a negative regulator of muscle growth, both structurally and phylogenetically. Though GDF11 is 90% structurally similar to myostatin, GDF11's...
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