positive regulation of transforming growth factor beta receptor signaling pathway
dendrite extension
TCR signalosome assembly
axonogenesis
glucose homeostasis
positive regulation of autophagy
phosphorylation
negative regulation of lipid biosynthetic process
positive regulation of axonogenesis
cellular response to DNA damage stimulus
regulation of dendrite morphogenesis
autophagy
protein phosphorylation
Golgi localization
regulation of Wnt signaling pathway
vasculature development
anoikis
cellular response to UV-B
negative regulation of cell growth
regulation of cell growth
tissue homeostasis
establishment of cell polarity
positive thymic T cell selection
positive regulation of peptidyl-tyrosine phosphorylation
regulation of protein kinase B signaling
canonical Wnt signaling pathway
intrinsic apoptotic signaling pathway by p53 class mediator
protein autophosphorylation
cell cycle
negative regulation of epithelial cell proliferation involved in prostate gland development
T cell receptor signaling pathway
spermatogenesis
activation of protein kinase activity
negative regulation of TORC1 signaling
negative regulation of cell population proliferation
positive regulation of protein localization to nucleus
apoptotic process
regulation of signal transduction by p53 class mediator
nervous system development
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
cell differentiation
positive regulation of protein serine/threonine kinase activity
protein dephosphorylation
negative regulation of canonical Wnt signaling pathway
negative regulation of cold-induced thermogenesis
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
6794
20869
Ensembl
ENSG00000118046
ENSMUSG00000003068
UniProt
Q15831
Q9WTK7
RefSeq (mRNA)
NM_000455
NM_001301853 NM_001301854 NM_011492
RefSeq (protein)
NP_000446
NP_001288782 NP_001288783 NP_035622
Location (UCSC)
Chr 19: 1.18 – 1.23 Mb
Chr 10: 79.95 – 79.97 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Serine/threonine kinase 11 (STK11) also known as liver kinase B1 (LKB1) or renal carcinoma antigen NY-REN-19 is a protein kinase that in humans is encoded by the STK11 gene.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000118046 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000003068 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Jenne DE, Reimann H, Nezu J, Friedel W, Loff S, Jeschke R, et al. (January 1998). "Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase". Nature Genetics. 18 (1): 38–43. doi:10.1038/ng0198-38. PMID 9425897. S2CID 28986057.
11 (STK11) also known as liver kinase B1 (LKB1) or renal carcinoma antigen NY-REN-19 is a protein kinase that in humans is encoded by the STK11 gene...
rare hereditary syndromes: Peutz–Jeghers syndrome due to mutations in the STK11 tumor suppressor gene (very rare, but a very strong risk factor); dysplastic...
often have inactivations of p53 and RB (~40%), or inactivation of TP53 and STK11 or KEAP1 (~40%). The World Health Organization classification of lung tumors...
without Raptor, no protein synthesis via mTORC1 occurs. LKB1, also known as STK11, is a known tumor suppressor that can activate AMPK. More studies on this...
including TP53 (mutated in 46% of cases), EGFR (27%), KRAS (32%), KEAP1, STK11 and NF1. EGFR and KRAS mutations tend to appear in a mutually exclusive...