Quiescent stage of the cell cycle in which the cell does not divide
Mitosis in an animal cell (phases ordered counter-clockwise), with G0 labeled at left.Many mammal cells, such as this 9x H neuron, remain permanently or semipermanently in G0.
The G0 phase describes a cellular state outside of the replicative cell cycle. Classically[when?], cells were thought to enter G0 primarily due to environmental factors, like nutrient deprivation, that limited the resources necessary for proliferation. Thus it was thought of as a resting phase. G0 is now known to take different forms and occur for multiple reasons. For example, most adult neuronal cells, among the most metabolically active cells in the body, are fully differentiated and reside in a terminal G0 phase. Neurons reside in this state, not because of stochastic or limited nutrient supply, but as a part of their developmental program.
G0 was first suggested as a cell state based on early cell cycle studies. When the first studies defined the four phases of the cell cycle using radioactive labeling techniques, it was discovered that not all cells in a population proliferate at similar rates.[1] A population's "growth fraction" – or the fraction of the population that was growing – was actively proliferating, but other cells existed in a non-proliferative state. Some of these non-proliferating cells could respond to extrinsic stimuli and proliferate by re-entering the cell cycle.[2] Early contrasting views either considered non-proliferating cells to simply be in an extended G1 phase or in a cell cycle phase distinct from G1 – termed G0.[3] Subsequent research pointed to a restriction point (R-point) in G1 where cells can enter G0 before the R-point but are committed to mitosis after the R-point.[4] These early studies provided evidence for the existence of a G0 state to which access is restricted. These cells that do not divide further exit G1 phase to enter an inactive stage called quiescent stage.
^Howard A, Pelc SR (2009). "Synthesis of Desoxyribonucleic Acid in Normal and Irradiated Cells and Its Relation to Chromosome Breakage". International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine. 49 (2): 207–218. doi:10.1080/09553008514552501. ISSN 0020-7616.
^Baserga R (2008). "Biochemistry of the Cell Cycle: A Review". Cell Proliferation. 1 (2): 167–191. doi:10.1111/j.1365-2184.1968.tb00957.x. ISSN 0960-7722. S2CID 86353634.
^Patt HM, Quastler H (July 1963). "Radiation effects on cell renewal and related systems". Physiological Reviews. 43 (3): 357–96. doi:10.1152/physrev.1963.43.3.357. PMID 13941891.
^Pardee AB (April 1974). "A restriction point for control of normal animal cell proliferation". Proceedings of the National Academy of Sciences of the United States of America. 71 (4): 1286–90. Bibcode:1974PNAS...71.1286P. doi:10.1073/pnas.71.4.1286. PMC 388211. PMID 4524638.
The G0phase describes a cellular state outside of the replicative cell cycle. Classically[when?], cells were thought to enter G0 primarily due to environmental...
S phase, it will leave the G1 phase and move into a state of dormancy called the G0phase. Most nonproliferating vertebrate cells will enter the G0 phase...
grows in size. In G1 phase, a cell has three options. To continue cell cycle and enter S phase Stop cell cycle and enter G0phase for undergoing differentiation...
cycle through G0 after completing the cycle. The cell can progress from G0 through terminal differentiation. The interphase refers to the phases of the cell...
Look up g0 in Wiktionary, the free dictionary. G0, G0, G0, g0, or G-zero, may refer to: G0phase of cell division G0 star, a subclass of G-class stars...
in G0. Interphase is the phase of the cell cycle in which a typical cell spends most of its life. Interphase is the "daily living" or metabolic phase of...
multiply only when needed. They spend most of the time in the quiescent G0phase of the cell cycle but can be stimulated to enter the cell cycle when needed...
phase, the DNA content (and thereby intensity of fluorescence) of cells in the G0phase and G1 phase (before S), in the S phase, and in the G2 phase and...
proceed or not, from one phase to another. Cells may also temporarily or permanently leave the cell cycle and enter G0phase to stop dividing. This can...
cellular components. The different stages of mitosis all together define the M phase of an animal cell cycle—the division of the mother cell into two genetically...
Quiescence, a type of dormancy in trees Quiescent phase, the first part of the first stage of childbirth The G0phase of a cell in the cell cycle; quiescence is...
G2 phase, Gap 2 phase, or Growth 2 phase, is the third subphase of interphase in the cell cycle directly preceding mitosis. It follows the successful...
of cells from the quiescent G0phase of the cell cycle into G1-, and subsequently progression through S-, G2- and M- phases of the cycle. Prior to 1960...
a cell is dependent on the phase of the cell cycle, increasing significantly during the transition from G0phase to S phase in mouse fibroblast and human...
Schematic karyograms generally display a DNA copy number corresponding to the G0phase of the cellular state (outside of the replicative cell cycle) which is...
the cell cycle. That is, the hepatocytes go from the quiescent G0phase to the G1 phase and undergo mitosis. This process is activated by the p75 receptors...
bone marrow. Labile cells exhibit a very short G1 phase and never enter G0phase (the resting phase), as they are continually proliferating throughout...
nutrients - has been shown to arrest and synchronize cell cycle progression in G0phase, for example in neonatal mammalian astrocytes and human foreskin fibroblasts...
However, since most micrometastatic tumor cells are in the nonproliferative G0phase[clarification needed], standard cytotoxic chemotherapies may not be as...
G2/M phase. Abrogation of the DREAM complex on the other hand, led to increased expression of E2F regulated genes normally repressed in the G0phase. Contrary...
activation of the mitotic checkpoint triggers apoptosis or reversion to the G0-phase of the cell cycle without cell division. The ability of paclitaxel to inhibit...
found associated with E2F-binding elements on E2F-target promoters during G0-phase. E2F-4 and 5 preferentially bind to p107/p130. E2F-6 acts as a transcriptional...
caused by shortened G1 phase, absent G0phase, and modifications in cell cycle checkpoints—which leaves the cells mostly in S phase at any given time. ESCs'...
replication The pupal phase of insect metamorphosis Resting spore G0phase or resting phase This disambiguation page lists articles associated with the title...
result, Rb is hypophosphorylated and inhibits E2F, promoting quiescence in G0-phase of the cell cycle. Mitogen stimulation mobilizes these cells into cycle...
targets IRS-1 at transcriptional level and inhibits transition from G1/G0phase to S phase during cell cycle in HEK293 and MCF-7 cells. Transgenic mice overexpressing...
karyogram of a typical human cell during the G0phase in relation to the cell cycle, which is most common phase among human cells, and wherein there will...
three phases and comes with several algorithms for each phase: Coarsen the graph by generating a sequence of graphs G0, G1, ..., GN, where G0 is the...
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