endoplasmic reticulum to Golgi vesicle-mediated transport
response to gravity
response to vitamin K
response to hydroxyisoflavone
cell adhesion
response to nutrient levels
regulation of osteoclast differentiation
osteoblast differentiation
response to inorganic substance
osteoblast development
response to ethanol
regulation of bone resorption
bone development
regulation of cellular response to insulin stimulus
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
632
12095
Ensembl
ENSG00000242252
ENSMUSG00000074489
UniProt
P02818
P54615
RefSeq (mRNA)
NM_199173
NM_031368 NM_001305448 NM_001305449 NM_001305450
RefSeq (protein)
NP_954642
NP_001292377 NP_001292378 NP_001292379 NP_112736
Location (UCSC)
Chr 1: 156.24 – 156.24 Mb
Chr 3: 88.28 – 88.28 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a small (49-amino-acid[5]) noncollagenous protein hormone found in bone and dentin, first identified as a calcium-binding protein.[6]
Because osteocalcin has gla domains, its synthesis is vitamin K dependent. In humans, osteocalcin is encoded by the BGLAP gene.[7][8] Its receptors include GPRC6A, GPR158, and possibly a third, yet-to-be-identified receptor.[9][10] There is evidence that GPR37 might be the third osteocalcin receptor.[11]
^ abcGRCh38: Ensembl release 89: ENSG00000242252 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000074489 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Hauschka PV, Carr SA, Biemann K (1982). "Primary structure of monkey osteocalcin". Biochemistry. 21 (4): 638–42. doi:10.1021/bi00533a006. PMID 6978733.
^Hauschka PV, Reid ML (August 1978). "Timed appearance of a calcium-binding protein containing gamma-carboxyglutamic acid in developing chick bone". Developmental Biology. 65 (2): 426–34. doi:10.1016/0012-1606(78)90038-6. PMID 680371.
^Puchacz E, Lian JB, Stein GS, Wozney J, Huebner K, Croce C (May 1989). "Chromosomal localization of the human osteocalcin gene". Endocrinology. 124 (5): 2648–50. doi:10.1210/endo-124-5-2648. PMID 2785029.
^Cancela L, Hsieh CL, Francke U, Price PA (September 1990). "Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene". The Journal of Biological Chemistry. 265 (25): 15040–8. doi:10.1016/S0021-9258(18)77221-9. PMID 2394711.
^Pi M, Wu Y, Quarles LD (July 2011). "GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo". Journal of Bone and Mineral Research. 26 (7): 1680–3. doi:10.1002/jbmr.390. PMC 5079536. PMID 21425331.
^Berger JM, Singh P, Khrimian L, Morgan DA, Chowdhury S, Arteaga-Solis E, et al. (September 2019). "Mediation of the Acute Stress Response by the Skeleton". Cell Metabolism. 30 (5): 890–902.e8. doi:10.1016/j.cmet.2019.08.012. PMC 6834912. PMID 31523009.
^Qian Z, Li H, Yang H, Yang Q, Lu Z, Wang L, et al. (October 2021). "Osteocalcin attenuates oligodendrocyte differentiation and myelination via GPR37 signaling in the mouse brain". Science Advances. 7 (43): eabi5811. Bibcode:2021SciA....7.5811Q. doi:10.1126/sciadv.abi5811. PMC 8535816. PMID 34678058.
Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a small (49-amino-acid) noncollagenous protein hormone found...
collagen and specialized proteins in much smaller quantities, including osteocalcin and osteopontin, which compose the organic matrix of bone. In organized...
synthesized in the liver and play an important role in blood homeostasis. Osteocalcin. This non-collagenous protein is secreted by osteoblasts and plays an...
release a hormone called osteocalcin, which contributes to the regulation of blood sugar (glucose) and fat deposition. Osteocalcin increases both insulin...
newborn infants. Osteocalcin is involved in calcification of bone tissue. The ratio of uncarboxylated osteocalcin to carboxylated osteocalcin increases with...
inhibition of blood clotting factors and the pro-bone-building hormone osteocalcin. Warfarin is a teratogen which can cross from the mother to the developing...
present in bone together with the related vitamin K2-dependent protein osteocalcin. In bone, its production is increased by vitamin D. The MGP was linked...
osteoid. The ground substance is mostly made up of chondroitin sulfate and osteocalcin. When there is insufficient nutrient minerals or osteoblast dysfunction...
developed modification in the Osteocalcin(burlap) gene, where premature termination of the gene was found. Osteocalcin gene regulates bone development...
functions as a receptor of L-α-amino acids, cations (e.g., calcium), osteocalcin, and steroids. It is a membrane androgen receptor. GPRC6A has also been...
amino acid residues. Trypsin, a digestive enzyme, uses the first method; osteocalcin, a bone matrix protein, uses the third. Some other bone matrix proteins...
C and S, and the factor X-targeting protein Z. The bone Gla protein osteocalcin, the calcification-inhibiting matrix Gla protein (MGP), the cell growth...
and serotonin, also affect how organisms react to stress. The hormone osteocalcin might also play a part. General adaptation syndrome regulates stress...
release a hormone called osteocalcin, which contributes to the regulation of blood sugar (glucose) and fat deposition. Osteocalcin increases both the insulin...
is used along with other bone markers such as alkaline phosphatase, osteocalcin, and N-terminal telopeptide to diagnose bone diseases such as postmenopausal...
Global Information
