Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound
Inositol trisphosphate or inositol 1,4,5-trisphosphate abbreviated InsP3 or Ins3P or IP3 is an inositol phosphate signaling molecule. It is made by hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2), a phospholipid that is located in the plasma membrane, by phospholipase C (PLC).
Together with diacylglycerol (DAG), IP3 is a second messenger molecule used in signal transduction in biological cells. While DAG stays inside the membrane, IP3 is soluble and diffuses through the cell, where it binds to its receptor, which is a calcium channel located in the endoplasmic reticulum. When IP3 binds its receptor, calcium is released into the cytosol, thereby activating various calcium regulated intracellular signals.
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Inositoltrisphosphate or inositol 1,4,5-trisphosphate abbreviated InsP3 or Ins3P or IP3 is an inositol phosphate signaling molecule. It is made by hydrolysis...
Inositoltrisphosphate receptor (InsP3R) is a membrane glycoprotein complex acting as a Ca2+ channel activated by inositoltrisphosphate (InsP3). InsP3R...
Inositol, primarily the isomer myo-inositol, is a carbocyclic sugar that is abundant in the brain and other mammalian tissues; it mediates cell signal...
heart and pancreas cells. Ryanodine receptors are similar to the inositoltrisphosphate (IP3 or InsP3) receptor, and stimulated to transport Ca2+ into the...
class Gq, which use upregulation of phospholipase C and, therefore, inositoltrisphosphate and intracellular calcium as a signaling pathway. A receptor so...
Inositol 1,4,5-trisphosphate receptor, type 3, also known as ITPR3, is a protein which in humans is encoded by the ITPR3 gene. The protein encoded by this...
Phosphatidylinositol or inositol phospholipid is a biomolecule. It was initially called "inosite" when it was discovered by Léon Maquenne and Johann Joseph...
phosphatidylinositol 4,5-bisphosphate (PIP2) to diacyl glycerol (DAG) and inositoltrisphosphate (IP3). IP3 acts as a second messenger to release stored calcium...
Inositol 1,4,5-trisphosphate receptor type 1 is a protein that in humans is encoded by the ITPR1 gene. ITPR1 has been shown to interact with: AHCYL1, CA8...
the arterial bed. The molecular mechanism involves inhibition of inositoltrisphosphate-induced Ca2+ release from the sarcoplasmic reticulum in arterial...
for his work on cell signaling, in particular the discovery that inositoltrisphosphate acts as a second messenger, linking events at the plasma membrane...
various inositol phosphates. Members of the family include inositol-polyphosphate multikinases, inositol-hexakisphosphate kinases, inositol-trisphosphate 3-kinases...
that bind to them are usually intracellular second messengers like inositoltrisphosphate (IP3) and extracellular lipophilic hormones like steroid hormones...
Inositol-trisphosphate 3-kinase A is an enzyme that in humans is encoded by the ITPKA gene. ITPKA is one of three inositol-trisphosphate 3-kinase (ITP3K)...
enzyme) that, through the same reaction, produces inositoltrisphosphate (IP3). Although inositoltrisphosphate diffuses into the cytosol, diacylglycerol remains...
Inositol-trisphosphate 3-kinase B is an enzyme that in humans is encoded by the ITPKB gene. The protein encoded by the ITPKB gene is one of 3 isoforms...
transduction. The enzyme phospholipase C produces diacylglycerol and inositoltrisphosphate, which increases calcium ion permeability into the membrane. Active...
class Gq that use upregulation of phospholipase C and, therefore, inositoltrisphosphate and intracellular calcium as a signalling pathway. A receptor so...
expressing Gi2. Coupling of the receptors to this protein mediates inositoltrisphosphate signaling. A number of human V1 receptor homologues have also been...
IP3 may refer to: Inositoltrisphosphate (IP3), used for signal transduction in biological cells Third-order intercept point, in radio telecommunication...
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