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Glycan information


The terms glycans and polysaccharides are defined by IUPAC as synonyms meaning "compounds consisting of a large number of monosaccharides linked glycosidically".[1] However, in practice the term glycan may also be used to refer to the carbohydrate portion of a glycoconjugate, such as a glycoprotein, glycolipid, or a proteoglycan, even if the carbohydrate is only an oligosaccharide.[2] Glycans usually consist solely of O-glycosidic linkages of monosaccharides. For example, cellulose is a glycan (or, to be more specific, a glucan) composed of β-1,4-linked D-glucose, and chitin is a glycan composed of β-1,4-linked N-acetyl-D-glucosamine. Glycans can be homo- or heteropolymers of monosaccharide residues, and can be linear or branched.

  1. ^ "Glycans". IUPAC Gold Book - Glycans. 2009. doi:10.1351/goldbook.G02645. ISBN 978-0-9678550-9-7.
  2. ^ Dwek, Raymond A. (1996). "Glycobiology: Toward Understanding the Function of Sugars". Chem. Rev. 96 (2): 683–720. doi:10.1021/cr940283b. PMID 11848770.

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Glycan

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The terms glycans and polysaccharides are defined by IUPAC as synonyms meaning "compounds consisting of a large number of monosaccharides linked glycosidically"...

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Glycan array

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Glycan arrays, like that offered by the Consortium for Functional Glycomics (CFG), National Center for Functional Glycomics (NCFG) and Z Biotech, LLC,...

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Glycoprotein

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cell. In contrast, perturbation of glycan processing (enzymatic removal/addition of carbohydrate residues to the glycan), which occurs in both the endoplasmic...

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Symbol Nomenclature For Glycans

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Nomenclature For Glycans (SNFG) is a community-curated standard for the depiction of simple monosaccharides and complex carbohydrates (glycans) using various...

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Glycan nomenclature

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Glycan nomenclature is the systematic naming of glycans, which are carbohydrate-based polymers made by all living organisms. In general glycans can be...

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Glycosylation

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Glycosylation is the reaction in which a carbohydrate (or 'glycan'), i.e. a glycosyl donor, is attached to a hydroxyl or other functional group of another...

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Glycobiology

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the structure, biosynthesis, and biology of saccharides (sugar chains or glycans) that are widely distributed in nature. Sugars or saccharides are essential...

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Glycomics

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Moreover, glycans can be modified (modified sugars), this increases its complexity. Complex biosynthetic pathways for glycans. Usually glycans are found...

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PIGA

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N-acetylglucosaminyltransferase subunit A (PIG-A, or phosphatidylinositol glycan, class A) is the catalytic subunit of the phosphatidylinositol...

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Glycome

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systematic study of all glycan structures of a given cell type or organism" and is a subset of glycobiology. "Carbohydrate", "glycan", "saccharide", and "sugar"...

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GlycoRNA

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GlycoRNAs are small non-coding RNAs with sialylated glycans. Glycans mediate inter- and intramolecular interactions by adding polysaccharide chains onto...

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Consortium for Functional Glycomics

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host glycans Immune recognition of glycans Glycans in immune cell communication Glycans in development and physiology Glycans in cancer biology Glycans in...

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Glycosylphosphatidylinositol

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Glycosylphosphatidylinositol (pronunciation) or glycophosphatidylinositol (GPI) is a phosphoglyceride that can be attached to the C-terminus of a protein...

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Glycopeptide

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Glycopeptides are peptides that contain carbohydrate moieties (glycans) covalently attached to the side chains of the amino acid residues that constitute...

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Fucose

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deoxy sugar with the chemical formula C6H12O5. It is found on N-linked glycans on the mammalian, insect and plant cell surface. Fucose is the fundamental...

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Autoimmune disease

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ME, Patel F, Wilken R, et al. (February 2015). "Glycans in the immune system and The Altered Glycan Theory of Autoimmunity: a critical review". Journal...

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National Center for Functional Glycomics

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projects are: Analysis of potential glycan-binding proteins on various glycan arrays (CFG glycan array, Microbial glycan array, NCFG-derived arrays)[clarification...

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Metabolism

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usually being used to maintained glucose level in blood. Polysaccharides and glycans are made by the sequential addition of monosaccharides by glycosyltransferase...

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Glyquest

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tool to help glycomics researchers to determine asparagine-linked glycan (N-glycan) structures based on collision-induced dissociation (CID) tandem mass...

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Lectin

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and autoreactive processes. Intelectins (X-type lectins) bind microbial glycans and may function in the innate immune system as well. Lectins may be involved...

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Scleroderma

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include endothelin receptor antagonists, tyrosine kinase inhibitors, beta-glycan peptides, halofuginone, basiliximab, alemtuzumab, abatacept, and haematopoietic...

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Mannose

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considerable amount of mannose residues due to the tight clustering of glycans in its viral spike. These mannose residues are the target for broadly neutralizing...

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HIV

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the mass of the trimeric envelope spike is N-linked glycans. The density is high as the glycans shield the underlying viral protein from neutralisation...

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Protein biosynthesis

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with the addition of a precursor glycan. The precursor glycan is modified in the Golgi apparatus to produce complex glycan bound covalently to the nitrogen...

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