This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. Find sources: "Calmodulin" – news · newspapers · books · scholar · JSTOR(December 2007) (Learn how and when to remove this message)
Calmodulin
3D structure of Ca2+-bound calmodulin (PDB: 1OSA)
Identifiers
Symbol
CaM
PDB
1OSA
UniProt
P62158
Search for
Structures
Swiss-model
Domains
InterPro
The helix–loop–helix structure of the calcium-binding EF hand motif
Calmodulin (CaM) (an abbreviation for calcium-modulated protein) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells.[1] It is an intracellular target of the secondary messenger Ca2+, and the binding of Ca2+ is required for the activation of calmodulin. Once bound to Ca2+, calmodulin acts as part of a calcium signal transduction pathway by modifying its interactions with various target proteins such as kinases or phosphatases.[2][3][4]
^Stevens FC (August 1983). "Calmodulin: an introduction". Canadian Journal of Biochemistry and Cell Biology. 61 (8): 906–10. doi:10.1139/o83-115. PMID 6313166.
^Chin D, Means AR (August 2000). "Calmodulin: a prototypical calcium sensor". Trends in Cell Biology. 10 (8): 322–8. doi:10.1016/S0962-8924(00)01800-6. PMID 10884684.
^Purves D, Augustine G, Fitzpatrick D, Hall W, LaMantia AS, White L (2012). Neuroscience. Massachusetts: Sinauer Associates. pp. 95, 147, 148. ISBN 9780878936953.
Calmodulin (CaM) (an abbreviation for calcium-modulated protein) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic...
CAMK, also written as CaMK or CCaMK, is an abbreviation for the Ca2+/calmodulin-dependent protein kinase class of enzymes. CAMKs are activated by increases...
Calmodulin 1 is a protein in humans that is encoded by the CALM1 gene. Calmodulin plays a role in calcium signal transduction pathways by regulating control...
In molecular biology, calmodulin binding domain (CaMBD) is a protein domain found in small-conductance calcium-activated potassium channels (SK channels)...
Calmodulin-regulated spectrin-associated protein family member 2 (CAMSAP2) is a protein in humans that is encoded by the CAMSAP2 gene. CAMSAP2 possesses...
variants involving a single protein system. Camgaroos take advantage of calmodulin (CaM), a calcium binding protein. In these structures, CaM is inserted...
Calmodulin-regulated spectrin-associated protein family member 3 (CAMSAP3) is a human protein encoded by the gene CAMSAP3. The protein is commonly referred...
(June 2016). "The chemosensitizing agent lubeluzole binds calmodulin and inhibits Ca(2+)/calmodulin-dependent kinase II". European Journal of Medicinal Chemistry...
neurotransmitter. Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS)....
(eEF-2 kinase or eEF-2K), also known as calmodulin-dependent protein kinase III (CAMKIII) and calcium/calmodulin-dependent eukaryotic elongation factor...
Calmodulin 2 is a protein that in humans is encoded by the CALM2 gene. A member of the calmodulin family of signaling molecules, it is an intermediary...
Calcium/calmodulin-dependent protein kinase kinase 2 is an enzyme that in humans is encoded by the CAMKK2 gene. The product of this gene belongs to the...
voltage gating, which are further influenced by calcium ions (Ca2+), pH and calmodulin. Chemical modulation entails the addition or removal of a functional group...
affinity purification, in which recombinant fusion proteins are bound to calmodulin beads and eluted out by adding EGTA. EGTA is often employed in dentistry...
regulatory protein calmodulin (CaM) and is also involved in responding to oxidative stress. Similarly, GAD in plants binds calmodulin as well. This interaction...
Calcium/calmodulin-dependent protein kinase kinase 1 is an enzyme that in humans is encoded by the CAMKK1 gene. The product of this gene belongs to the...
Calmodulin-regulated spectrin-associated protein 1 (CAMSAP1) is a human protein encoded by the gene CAMSAP1. Like other CAMSAP-family proteins, it is a...
Global Information
