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Calcium signaling information


Shows Ca2+ release from the endoplasmic reticulum through phospholipase C (PLC) pathway.

Calcium signaling is the use of calcium ions (Ca2+) to communicate and drive intracellular processes often as a step in signal transduction. Ca2+ is important for cellular signalling, for once it enters the cytosol of the cytoplasm it exerts allosteric regulatory effects on many enzymes and proteins. Ca2+ can act in signal transduction resulting from activation of ion channels or as a second messenger caused by indirect signal transduction pathways such as G protein-coupled receptors.

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Calcium signaling

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Calcium signaling is the use of calcium ions (Ca2+) to communicate and drive intracellular processes often as a step in signal transduction. Ca2+ is important...

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Calcium signaling in Arabidopsis

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Calcium signaling in Arabidopsis is a calcium mediated signalling pathway that Arabidopsis plants use in order to respond to a stimuli. In this pathway...

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Wnt signaling pathway

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the shape of the cell. The noncanonical Wnt/calcium pathway regulates calcium inside the cell. Wnt signaling was first identified for its role in carcinogenesis...

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Mitochondrion

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(mitochondria-associated ER-membrane). This is important in the ER-mitochondria calcium signaling and is involved in the transfer of lipids between the ER and mitochondria...

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Calcium signaling in cell division

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Calcium plays a crucial role in regulating the events of cellular division. Calcium acts both to modulate intracellular signaling as a secondary messenger...

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Calcium in biology

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Calcium ions (Ca2+) contribute to the physiology and biochemistry of organisms' cells. They play an important role in signal transduction pathways, where...

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Calmodulin

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short-term and long-term memory, and the immune response. Calcium participates in an intracellular signaling system by acting as a diffusible second messenger...

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Calcium channel blocker

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Calcium channel blockers (CCB), calcium channel antagonists or calcium antagonists are a group of medications that disrupt the movement of calcium (Ca2+...

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Calcium channel

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membranes. Calcium channels can also be used to release calcium ions as second messengers within the cell, affecting downstream signaling pathways.  ...

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Ricardo Dolmetsch

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and store-operated calcium channels. The lab developed technologies to study cell signaling, including light-activated signaling proteins to control...

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Inositol trisphosphate

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Today the IP3 signaling pathway is well mapped out, and is known to be important in regulating a variety of calcium-dependent cell signaling pathways. Increases...

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Second messenger system

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intracellular signaling molecules released by the cell in response to exposure to extracellular signaling molecules—the first messengers. (Intercellular signals, a...

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GCaMP

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disrupts L-type calcium channel gating, the added calmodulin-binding motif prevents GCaMP-X from interfering with calcium-dependent signaling mechanisms....

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Phospholipase

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release of bound calcium from cellular stores and the consequent increase in free cytosolic Ca2+, an essential step in calcium signaling to regulate intracellular...

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Calcium imaging

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Calcium imaging is a microscopy technique to optically measure the calcium (Ca2+) status of an isolated cell, tissue or medium. Calcium imaging takes...

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Signal transduction

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signal sensing) in a receptor give rise to a biochemical cascade, which is a chain of biochemical events known as a signaling pathway. When signaling...

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Calmodulin 1

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interference of vital calcium signaling events within the heart muscle which disrupts membrane ion channels. The disruptions in cell signaling can lead to potentially...

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Calcium concentration microdomains

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(μM). These microdomains take part in calcium signaling, which has a diverse range of potential outcomes. Calcium concentration microdomains can be visualised...

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Dysferlin

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Dysferlin is linked with plasma membrane repair., stabilization of calcium signaling and the development of the T-tubule system of the muscle A defect...

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Ryanodine receptor

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found in different tissues and participate in different signaling pathways involving calcium release from intracellular organelles. The RYR2 ryanodine...

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Cardiac action potential

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blockers, and calcium channel blockers. Zhao, G; Qiu, Y; Zhang, HM; Yang, D (January 2019). "Intercalated discs: cellular adhesion and signaling in heart health...

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Gq alpha subunit

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downstream signaling enzymes. Gq/11/14/15 proteins all activate beta-type phospholipase C (PLC-β) to signal through calcium and PKC signaling pathways....

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Calretinin

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as calbindin 2 (formerly 29 kDa calbindin), is a calcium-binding protein involved in calcium signaling. In humans, the calretinin protein is encoded by...

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Mitochondrial calcium uniporter

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contains stores of cellular calcium ions for calcium signaling. The presence of 1,4,5-triphosphate (IP3) triggers the release of calcium from these intracellular...

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