regulation of ryanodine-sensitive calcium-release channel activity
negative regulation of calcium ion binding
regulation of cardiac conduction
regulation of calcium ion transport
negative regulation of catalytic activity
regulation of heart contraction
regulation of cytosolic calcium ion concentration
cardiac muscle tissue development
negative regulation of heart contraction
response to testosterone
regulation of the force of heart contraction
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
negative regulation of ATP-dependent activity
regulation of ATPase-coupled calcium transmembrane transporter activity
regulation of calcium ion import
response to zinc ion
cellular calcium ion homeostasis
regulation of relaxation of cardiac muscle
negative regulation of calcium ion transmembrane transporter activity
blood circulation
negative regulation of heart rate
negative regulation of calcium ion import
response to insulin
regulation of cardiac muscle cell contraction
negative regulation of ATPase-coupled calcium transmembrane transporter activity
negative regulation of calcium ion transport
adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
regulation of cardiac muscle cell membrane potential
regulation of the force of heart contraction by cardiac conduction
regulation of relaxation of muscle
negative regulation of calcium ion import into sarcoplasmic reticulum
protein homooligomerization
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
relaxation of cardiac muscle
calcium ion transport
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
5350
18821
Ensembl
ENSG00000198523
ENSMUSG00000038583
UniProt
P26678
P61014
RefSeq (mRNA)
NM_002667
NM_001141927 NM_023129
RefSeq (protein)
NP_002658
NP_001135399 NP_075618
Location (UCSC)
Chr 6: 118.55 – 118.56 Mb
Chr 10: 53.21 – 53.22 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Phospholamban, also known as PLN or PLB, is a micropeptide protein that in humans is encoded by the PLN gene.[5] Phospholamban is a 52-amino acid integral membrane protein that regulates the calcium (Ca2+) pump in cardiac muscle cells.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000198523 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000038583 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Fujii J, Zarain-Herzberg A, Willard HF, Tada M, MacLennan DH (June 1991). "Structure of the rabbit phospholamban gene, cloning of the human cDNA, and assignment of the gene to human chromosome 6". The Journal of Biological Chemistry. 266 (18): 11669–75. doi:10.1016/S0021-9258(18)99009-5. PMID 1828805.
^Rodriguez P, Kranias EG (December 2005). "Phospholamban: a key determinant of cardiac function and dysfunction". Archives des Maladies du Coeur et des Vaisseaux. 98 (12): 1239–43. PMID 16435604.
Phospholamban, also known as PLN or PLB, is a micropeptide protein that in humans is encoded by the PLN gene. Phospholamban is a 52-amino acid integral...
releasing the Ca2+ into the SR. A protein found in cardiac muscle, called phospholamban (PLB) has been shown to prevent SERCA from working. It does this by...
effects including phosphorylating phospholamban (via Protein kinase A). Phosphorylating phospholamban. When phospholamban is not phosphorylated, it inhibits...
up by the mitochondria. An enzyme, phospholamban, serves as a brake for SERCA. At low heart rates, phospholamban is active and slows down the activity...
across the SR membrane can be controlled by the regulatory protein phospholamban (PLB/PLN). SERCA is not as active when PLB is bound to it. Increased...
M, MacLennan DH (July 2002). "Sarcolipin inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases...
and phosphorylates numerous targets, namely: L-type calcium channels, phospholamban, troponin I, myosin binding protein C, and potassium channels. This...
(SERCA) by binding to transmembrane helices alone or in association with phospholamban". Proceedings of the National Academy of Sciences of the United States...
genotype-phenotype associations in DCM and mutations in lamin (LMNA), phospholamban (PLN), RNA Binding Motif Protein 20 (RBM20), Cardiac Myosin Binding...
by phospholamban and higher phospholamban-to-SERCA2a ratios cause SERCA inhibition and impaired relaxation. Istaroxime reduces SERCA2a-phospholamban interaction...
Perusahaan Listrik Negara, Indonesian government-owned electricity company Phospholamban, a protein Peripheral lymph node Pln, the abbreviation for the orchid...
relax more rapidly. This effect is mediated by the phosphorylation of phospholamban and troponin I via a cAMP-dependent pathway. Catecholamine-induced calcium...
stimuli by enhancing Ca2+ release from the SR during EC coupling. Also, phospholamban phosphorylation is increased in myostatin-knockout mice, leading to...
suggested to play a role in the development of heart failure. Modulated by phospholamban (PLB), SERCA2 regulates uptake of Ca2+ into the sarcoplasmic reticulum...
This activation of SERCA2a is indirectly by the phosphorylation of phospholamban (PLN) by calmodulin kinase II (CAMK). Positive Bowditch effect causes...
form of dilated cardiomyopathy due to a mutation in gene encoding the Phospholamban protein. Further activation proved therapeutic in a human induced pluripotent...
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