antimicrobial humoral immune response mediated by antimicrobial peptide
regulation of signaling receptor activity
G protein-coupled receptor signaling pathway
cytokine-mediated signaling pathway
neutrophil chemotaxis
leukocyte chemotaxis
cellular response to lipopolysaccharide
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2920
14825
Ensembl
ENSG00000081041
ENSMUSG00000029380
UniProt
P19875
P12850
RefSeq (mRNA)
NM_002089
NM_008176
RefSeq (protein)
NP_002080
NP_032202
Location (UCSC)
Chr 4: 74.1 – 74.1 Mb
Chr 5: 91.04 – 91.04 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
chemokine (C-X-C motif) ligand 2
Identifiers
Symbol
CXCL2
Alt. symbols
SCYB2, GRO2, GROb, MIP-2a, MGSA-b, CINC-2a
NCBI gene
2920
HGNC
4603
OMIM
139110
RefSeq
NM_002089
UniProt
P19875
Other data
Locus
Chr. 4 q21
Search for
Structures
Swiss-model
Domains
InterPro
Chemokine (C-X-C motif) ligand 2 (CXCL2) is a small cytokine belonging to the CXC chemokine family that is also called macrophage inflammatory protein 2-alpha (MIP2-alpha), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2). CXCL2 is 90% identical in amino acid sequence as a related chemokine, CXCL1. This chemokine is secreted by monocytes and macrophages and is chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells.[5][6][7] The gene for CXCL2 is located on human chromosome 4 in a cluster of other CXC chemokines.[8] CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2.[7]
CXCL2, like related chemokines, is also a powerful neutrophil chemoattractant and is involved in many immune responses including wound healing, cancer metastasis, and angiogenesis.[9] A study was published in 2013 testing the role of CXCL2, CXCL3, and CXCL1 in the migration of airway smooth muscle cells (ASMCs) migration which plays a significant role in asthma. The results of this study showed that CXCL2 and CXCL3 both help with the mediation of normal and asthmatic ASMC migration through different mechanisms.[9]
^ abcGRCh38: Ensembl release 89: ENSG00000081041 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000029380 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Wolpe SD, Sherry B, Juers D, Davatelis G, Yurt RW, Cerami A (January 1989). "Identification and characterization of macrophage inflammatory protein 2". Proceedings of the National Academy of Sciences of the United States of America. 86 (2): 612–6. Bibcode:1989PNAS...86..612W. doi:10.1073/pnas.86.2.612. PMC 286522. PMID 2643119.
^Iida N, Grotendorst GR (October 1990). "Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue". Molecular and Cellular Biology. 10 (10): 5596–9. doi:10.1128/mcb.10.10.5596. PMC 361282. PMID 2078213.
^O'Donovan N, Galvin M, Morgan JG (1999). "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenetics and Cell Genetics. 84 (1–2): 39–42. doi:10.1159/000015209. PMID 10343098. S2CID 8087808.
^ abAl-Alwan LA, Chang Y, Mogas A, Halayko AJ, Baglole CJ, Martin JG, et al. (September 2013). "Differential roles of CXCL2 and CXCL3 and their receptors in regulating normal and asthmatic airway smooth muscle cell migration". Journal of Immunology. 191 (5): 2731–41. doi:10.4049/jimmunol.1203421. PMC 3748335. PMID 23904157.
Chemokine (C-X-C motif) ligand 2 (CXCL2) is a small cytokine belonging to the CXC chemokine family that is also called macrophage inflammatory protein...
conditions. The reaction mechanism involves free radicals of the general formula CXCl2 (X = Cl, H). For the precursors carbon tetrachloride and chloroform, the...
area. Typical inflammatory chemokines include: CCL2, CCL3 and CCL5, CXCL1, CXCL2 and CXCL8. A typical example is CXCL-8, which acts as a chemoattractant...
the infection site. Macrophages secrete many chemokines such as CXCL1, CXCL2, and CXCL8 (IL-8) that attract neutrophils to the site of infection. After...
skin IL-32 - Induces monocytes and macrophages to secrete TNF-α, IL-8 and CXCL2 IL-33 epithelial cells Induces helper T cells to produce type 2 cytokine...
also CCR1 and CCR3. MIP-2 belongs to the CXC chemokine family, is named CXCL2 and acts through binding of CXCR1 and CXCR2. It is produced mainly by macrophages...
Global Information
