negative regulation of transcription by RNA polymerase II
retinal cell programmed cell death
transcription, DNA-templated
response to lipopolysaccharide
positive regulation of neuron apoptotic process
positive regulation of endothelial cell apoptotic process
necroptotic signaling pathway
immune response
positive regulation of cell population proliferation
positive regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of angiogenesis
regulation of extrinsic apoptotic signaling pathway via death domain receptors
cellular chloride ion homeostasis
response to growth factor
inflammatory cell apoptotic process
positive regulation of epidermal growth factor receptor signaling pathway
extrinsic apoptotic signaling pathway via death domain receptors
signal transduction
extrinsic apoptotic signaling pathway
activation of cysteine-type endopeptidase activity involved in apoptotic process
necroptosis
apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
apoptotic process
release of sequestered calcium ion into cytosol by endoplasmic reticulum
regulation of signaling receptor activity
cytokine-mediated signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
356
14103
Ensembl
ENSG00000117560
ENSMUSG00000000817
UniProt
P48023
P41047
RefSeq (mRNA)
NM_001302746 NM_000639
NM_001205243 NM_010177
RefSeq (protein)
NP_000630 NP_001289675
NP_001192172 NP_034307
Location (UCSC)
Chr 1: 172.66 – 172.67 Mb
Chr 1: 161.61 – 161.62 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Fas ligand (FASL or CD95L) is a type-II transmembrane protein expressed on various types of cells, including cytotoxic T lymphocytes, monocytes, neutrophils, breast epithelial cells, vascular endothelial cells and natural killer (NK) cells. It binds with its receptor, called FAS receptor (also called CD95) and plays a crucial role in the regulation of the immune system and in induction of apoptosis, a programmed cell death. [5]
^ abcGRCh38: Ensembl release 89: ENSG00000117560 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000000817 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Liu W, Ramagopal U, Cheng H, Bonanno JB, Toro R, Bhosle R, Zhan C, Almo SC (2016-11-01). "Crystal Structure of the Complex of Human FasL and Its Decoy Receptor DcR3". Structure. 24 (11): 2016–2023. doi:10.1016/j.str.2016.09.009. ISSN 0969-2126. PMID 27806260.
Fasligand (FASL or CD95L) is a type-II transmembrane protein expressed on various types of cells, including cytotoxic T lymphocytes, monocytes, neutrophils...
The Fas receptor is a death receptor on the surface of cells that leads to programmed cell death (apoptosis) if it binds its ligand, Fasligand (FasL)....
expression on activated B and T lymphocytes and Fas-ligand on activated T lymphocytes. Fas and Fas-ligand interact to trigger the caspase cascade, leading...
associated with five ligand-receptor systems involved in cell death: tumor necrosis factor alpha (TNF alpha) and receptors Fasligand and receptors TNF-related...
The fas receptor (First apoptosis signal) – (also known as Apo-1 or CD95) is a transmembrane protein of the TNF family which binds the Fasligand (FasL)...
cleavage of cell surface receptors, the release of apoptotic ligands (such as the FASligand), and chemokine/cytokine inactivation. MMPs are also thought...
protein FASligand (FasL)(Apo1L)(CD95L), which can bind to Fas (Apo1)(CD95) molecules expressed on the target cell. However, this Fas-Fasligand interaction...
hydrophobic interactions. Upon stimulation by the Fasligand, the Fas receptor trimerises. Many receptors, including Fas, contain a cytoplasmic DD and are therefore...
for the fibroblast activation protein Fas-associated phosphatase, a molecule that inhibits the effect of Fasligand to make cells initiate apoptosis Final...
adherent cells and their effects on the cell surface expression of Fas receptor and Fasligand". Scientific Reports. 12 (1): 5713. Bibcode:2022NatSR..12.5713L...
programmed cell death caused by the interaction of Fas receptor (Fas, CD95)and Fasligand (FasL, CD95 ligand). It occurs as a result of repeated stimulation...
different part of the body. FAS/FAS-L system – expression of Fasligand (Fas-L) on the surface of SCs activates apoptotic death of Fas receptor-bearing cells...
protein of the tumor necrosis factor receptor superfamily which inhibits Fasligand-induced apoptosis. Dcr3 was identified in 1998 by the search of genes...
effect on cell growth or cell proliferation. Some cytokines, such as Fasligand, are used as "death" signals; they cause target cells to undergo programmed...
"Estrogen prevents bone loss via estrogen receptor alpha and induction of Fasligand in osteoclasts". Cell. 130 (5): 811–823. doi:10.1016/j.cell.2007.07.025...
P, Devadas S (August 2016). "Inherent low Erk and p38 activity reduce FasLigand expression and degranulation in T helper 17 cells leading to activation...
cytotoxicity receptors directly induce apoptosis (cell death) after binding to Fasligand that directly indicate infection of a cell. The MHC-independent receptors...
factor in 1986. He also identified a death factor (Fas receptor) in 1991 and its ligand (Fasligand) in 1993, and elucidated their physiological and pathological...
via a pathway dependent on caspase-8 activation but independent on Fas/Fasligand interaction in colon cancer HT-29 cells". Carcinogenesis. 23 (12): 2087–93...
fibrosis (IPF), chronic HP is related to increased expression of Fas antigen and Fasligand, leading to increased epithelial apoptosis activation in the alveoli...
editors. Open access. van Parijs L, Peterson DA, and Abbas AK (1998) The Fas/FasLigand Pathway and Bcl-2 Regulate T Cell Responses to Model Self and Foreign...
Global Information
