mature B cell differentiation involved in immune response
positive regulation of immunoglobulin production in mucosal tissue
adaptive immune response
immune system process
regulation of signaling receptor activity
signal transduction
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
100141515
77727
Ensembl
ENSG00000187997
ENSMUSG00000025573
UniProt
Q6UX52
Q9CX63
RefSeq (mRNA)
NM_001163075
NM_029964
RefSeq (protein)
NP_001156547
NP_084240
Location (UCSC)
Chr 17: 78.15 – 78.17 Mb
Chr 11: 117.69 – 117.7 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Interleukin 40 (IL-40), also known with other name C17orf99, is a protein belonging to a group of cytokines called interleukins. It is encoded by a gene that does not belong to any cytokine superfamily.[5] This cytokine is produced primarily by human expression tissues such as bone marrow and fetal liver, and its expression can be also induced in peripheral B cells after activation.[6] IL-40 is involved in immunoglobulin A (IgA) production, and plays an important role in humoral immune responses and B cell homeostasis and development.[7][8]
^ abcGRCh38: Ensembl release 89: ENSG00000187997 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000025573 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Zlotnik A (2020-05-15). "Perspective: Insights on the Nomenclature of Cytokines and Chemokines". Frontiers in Immunology. 11: 908. doi:10.3389/fimmu.2020.00908. PMC 7243804. PMID 32499780.
^Zingaretti C, Arigò M, Cardaci A, Moro M, Crosti M, Sinisi A, et al. (December 2012). "Identification of new autoantigens by protein array indicates a role for IL4 neutralization in autoimmune hepatitis". Molecular & Cellular Proteomics. 11 (12): 1885–1897. doi:10.1074/mcp.M112.018713. PMC 3518104. PMID 22997428.
^Catalan-Dibene J, McIntyre LL, Zlotnik A (October 2018). "Interleukin 30 to Interleukin 40". Journal of Interferon & Cytokine Research. 38 (10): 423–439. doi:10.1089/jir.2018.0089. PMC 6206549. PMID 30328794.
^Mertowska P, Mertowski S, Smarz-Widelska I, Grywalska E (January 2022). "Biological Role, Mechanism of Action and the Importance of Interleukins in Kidney Diseases". International Journal of Molecular Sciences. 23 (2): 647. doi:10.3390/ijms23020647. PMC 8775480. PMID 35054831.
Interleukin40 (IL-40), also known with other name C17orf99, is a protein belonging to a group of cytokines called interleukins. It is encoded by a gene...
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Interleukin 17F (IL-17F) is signaling protein that is in human is encoded by the IL17F gene and is considered a pro-inflammatory cytokine. This protein...
refer to: Interleukin-12 subunit beta Neutrophil cytosolic factor 4 Ribosomal protein SA Brazilian patrol boat Grajaú (P40) Carro Armato P 40, an Italian...
Interleukin-2 receptor subunit beta is a protein that in humans is encoded by the IL2RB gene. Also known as CD122; IL15RB; P70-75. The interleukin 2 receptor...
Interleukin 17 receptor A, also known as IL17RA and CDw217 (cluster of differentiation w217), is a human gene. Interleukin 17A (IL17A)is a proinflammatory...
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