5,6-Dihydroxyindole, the monomer out of which neuromelanin polymers are formed
Neuromelanin (NM) is a dark pigment found in the brain which is structurally related to melanin. It is a polymer of 5,6-dihydroxyindole monomers.[1] Neuromelanin is found in large quantities in catecholaminergic cells of the substantia nigra pars compacta and locus coeruleus, giving a dark color to the structures.[2]
^Charkoudian LK, Franz KJ (2006). "Fe(III)-coordination properties of neuromelanin components: 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid". Inorganic Chemistry. 45 (9): 3657–64. doi:10.1021/ic060014r. PMID 16634598.
^Fedorow, H; Tribl, F; Halliday, G; Gerlach, M; Riederer, P; Double, K. L. (2005). "Neuromelanin in human dopamine neurons: Comparison with peripheral melanins and relevance to Parkinson's disease". Progress in Neurobiology. 75 (2): 109–24. doi:10.1016/j.pneurobio.2005.02.001. PMID 15784302. S2CID 503902.
Neuromelanin (NM) is a dark pigment found in the brain which is structurally related to melanin. It is a polymer of 5,6-dihydroxyindole monomers. Neuromelanin...
melanocytes. There are five basic types of melanin: eumelanin, pheomelanin, neuromelanin, allomelanin and pyomelanin. Eumelanin is produced through a multistage...
nerve cell bodies of the pars compacta are coloured black by the pigment neuromelanin. The degree of pigmentation increases with age. This pigmentation is...
substantia nigra appear darker than neighboring areas due to high levels of neuromelanin in dopaminergic neurons. Parkinson's disease is characterized by the...
substantia nigra, the latter of which contains neuromelanin-pigmented neurons. The similarly neuromelanin-pigmented cell bodies of the locus coeruleus produce...
the pons." The neuromelanin is formed by the polymerization of norepinephrine and is analogous to the black dopamine-based neuromelanin in the substantia...
and ISO-3166-2:CN code NM) Nemaline myopathy, a neuromuscular disorder Neuromelanin, a dark pigment found in the brain Nuclear medicine, a medical imaging...
recovery (SPIR) This method exploits the paramagnetic properties of neuromelanin and can be used to visualize the substantia nigra and the locus coeruleus...
strand-like Lewy neurites and rounded Lewy bodies of various sizes. Neuromelanin-laden cells of the substantia nigra are visible in the background. Stains...
adrenochrome may be produced normally as an intermediate in the formation of neuromelanin. This finding may be significant because adrenochrome is detoxified at...
larger neurofibrils. Some neurons also contain pigment granules, such as neuromelanin (a brownish-black pigment that is byproduct of synthesis of catecholamines)...
sections because the dopamine neurons contain a black pigment called neuromelanin which is known to accumulate with age. The dopaminergic cell bodies in...
cells (origin of the Latin name, substantia nigra), but rather is due to neuromelanin. Outside the brain, hemoglobin has non-oxygen-carrying functions as an...
the major lipid component (14% by mass) of human substantia nigra (SN) neuromelanin. Dolichol phosphate was discovered at the University of Liverpool in...
The ‘’black substance’’ that the term translates as, refers to the neuromelanin found in the dopaminergic neurons. These are found in a darker region...
Halliday, GM; Garner, B; Brunk, UT (June 2008). "The comparative biology of neuromelanin and lipofuscin in the human brain". Cellular and Molecular Life Sciences...
cores, in structures that correlate to layers of ferritin outside of neuromelanin organelles. Evidence of ferritin layers in cell bodies of large dopamine...
precursor but not dopamine. However, there is substantial evidence that the neuromelanin that gives a dark color to the brain's substantia nigra is at least in...
strongly to facing bodies. Experiments have shown that ferritin and neuromelanin in fixed human substantia nigra pars compacta (SNc) tissue are able to...
containing neuromelanin are more susceptible to Parkinson's related cell death than nonmelanized catecholaminergic neurons. Neuromelanin is an autoxidation...
interactions between impaired neuronal iron uptake and the functions of the neuromelanin-containing and dopamine-producing cells have roles in RLS development...
postmortem brain samples argued for an SNpc alteration, evidenced by neuromelanin hypopigmentation, reduction in the structure area, and even, controversially...
pars compacta of the substantia nigra as seen from the accumulation of neuromelanin pigment in the midbrain of healthy, adult humans.[citation needed] Group...
OCLC 1003273264. Rourk, Christopher John (September 2018). "Ferritin and neuromelanin "quantum dot" array structures in dopamine neurons of the substantia...
which can be broken down into three major components: 1) Ferritin and neuromelanin are present in high concentrations in those neurons, but it was unknown...
norepinephrine), to an indole derivative that can serve as a precursor to neuromelanin. Human genes encoding proteins that contain this domain include DDT and...
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