Trifluoperazine information

Trifluoperazine
Clinical data
Trade names	Stelazine, Eskazinyl, Eskazine, Jatroneural, others
AHFS/Drugs.com	Monograph
MedlinePlus	a682121
Pregnancy; category	AU: C; ;
Routes of; administration	By mouth, IM
Drug class	Typical antipsychotic
ATC code	N05AB06 (WHO) ;
Legal status
Legal status	BR: Class C1 (Other controlled substances); UK: POM (Prescription only); US: WARNINGRx-only;
Pharmacokinetic data
Metabolism	Liver
Elimination half-life	10–20 hours
Identifiers
	IUPAC name 10-[3-(4-methylpiperazin-1-yl)propyl]-; 2-(trifluoromethyl)-10H-phenothiazine;
CAS Number	117-89-5 ;
PubChem CID	5566;
IUPHAR/BPS	214;
DrugBank	DB00831 ;
ChemSpider	5365 ;
UNII	214IZI85K3;
ChEBI	CHEBI:45951 ;
ChEMBL	ChEMBL422 ;
PDB ligand	TFP (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID1046928 ;
ECHA InfoCard	100.003.837
Chemical and physical data
Formula	C21H24F3N3S
Molar mass	407.50 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES FC(F)(F)c2cc1N(c3c(Sc1cc2)cccc3)CCCN4CCN(C)CC4;
	InChI InChI=1S/C21H24F3N3S/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24/h2-3,5-8,15H,4,9-14H2,1H3 ; Key:ZEWQUBUPAILYHI-UHFFFAOYSA-N ;
	(verify)

Trifluoperazine, marketed under the brand name Stelazine among others, is a typical antipsychotic primarily used to treat schizophrenia.^[3] It may also be used short term in those with generalized anxiety disorder but is less preferred to benzodiazepines.^[3] It is of the phenothiazine chemical class. It was approved for medical use in the United States in 1959.^[4]

^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^ ^a ^b "Trifluoperazine Hydrochloride". The American Society of Health-System Pharmacists. Retrieved 8 January 2017.
^ Howland RH (January 2016). "Trifluoperazine: A Sprightly Old Drug". Journal of Psychosocial Nursing and Mental Health Services. 54 (1): 20–2. doi:10.3928/02793695-20151223-01. PMID 26760133.

[FDA-AllBoxedWarnings-1] "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.

[2] Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

[AHFS2017-3] "Trifluoperazine Hydrochloride". The American Society of Health-System Pharmacists. Retrieved 8 January 2017.

[Howland2016-4] Howland RH (January 2016). "Trifluoperazine: A Sprightly Old Drug". Journal of Psychosocial Nursing and Mental Health Services. 54 (1): 20–2. doi:10.3928/02793695-20151223-01. PMID 26760133.

Trifluoperazine information

and 25 Related for: Trifluoperazine information

Trifluoperazine

List of antidepressants

Spontaneous orgasm

List of psychiatric medications

Cocaine

MDMA

Sedative

Phencyclidine

Ketamine

List of psychotropic medications

Methamphetamine

LSD

Brazilian Controlled Drugs and Substances Act

Amitriptyline

Barbiturate

Lorazepam

Dopaminergic

Chlorpromazine

Monoamine oxidase inhibitor

Sildenafil

Fregoli delusion

Antipsychotic

Olanzapine

Buprenorphine

Haloperidol