Tolazoline is a non-selective competitive α-adrenergic receptor antagonist.[1] It is a vasodilator that is used to treat spasms of peripheral blood vessels (as in acrocyanosis). It has also been used (in conjunction with sodium nitroprusside) successfully as an antidote to reverse the severe peripheral vasoconstriction which can occur as a result of overdose with certain 5-HT2A agonist drugs such as 25I-NBOMe,[2] DOB and Bromodragonfly (prolonged severe vasoconstriction can lead to gangrene if untreated).[3][4]
It is however most commonly used in veterinary medicine, to reverse xylazine-induced sedation.[5][6]
^Aronson, J. K. (2016). Meyler's side effects of drugs : the international encyclopedia of adverse drug reactions and interactions. Amsterdam: Elsevier Science. ISBN 978-0-444-53717-1. OCLC 927102885. Tolazoline is an α2 adrenoceptor antagonist that increases skin blood flow in healthy subjects and has been used to relieve acute vasospasm.
^Thorlacius K, Borna C, Personne M (2008). "[Bromo-dragon fly--life-threatening drug. Can cause tissue necrosis as demonstrated by the first described case]". Läkartidningen (in Swedish). 105 (16): 1199–200. PMID 18522262.
^Boothe DM (2001). "Anticonvulsant drugs and analeptic agents". In Adams HR (ed.). Veterinary pharmacology and therapeutics. Ames: Iowa State University Press. pp. 378–9. ISBN 0-8138-1743-9. Retrieved 8 September 2008.
^Hall LW, Clarke KW, Trim CM (2001). "Principles of sedation, analgesia and premedication". Veterinary anaesthesia. Philadelphia: W.B. Saunders. pp. 90–1. ISBN 0-7020-2035-4.
Tolazoline is a non-selective competitive α-adrenergic receptor antagonist. It is a vasodilator that is used to treat spasms of peripheral blood vessels...
and tolazoline in tissues from yearling cattle and milk from mature dairy cows after sedation with xylazine hydrochloride and reversal with tolazoline hydrochloride"...
mass: 160.22 g/mol) may refer to: Anabaseine Anatabine Echinopsidine Tolazoline Tryptamine This set index page lists chemical structure articles associated...
cryopreservation when used in conjunction with verapamil, phentolamine, nifedipine, tolazoline or nitroprusside. Papaverine is also being investigated as a topical growth...
dialysis and plasma exchange also may be of benefit.[citation needed] Tolazoline (Priscoline) has been shown to offer symptomatic relief from sympathetic...
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