SYT1 information

SYT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2K45, 2K4A, 2K8M, 2KI6, 2LHA, 2N1T, 2R83, 3F00, 3F01, 3F04, 3F05, 4ISQ, 4V11
Identifiers
Aliases	SYT1, P65, SVP65, SYT, synaptotagmin 1, BAGOS
External IDs	OMIM: 185605; MGI: 99667; HomoloGene: 4122; GeneCards: SYT1; OMA:SYT1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	79,452,008 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	108,846,843 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; endothelial cell; ; lateral nuclear group of thalamus; ; orbitofrontal cortex; ; frontal pole; ; superior frontal gyrus; ; pons; ; Brodmann area 10; ; cerebellar vermis;
	Top expressed in
	medial dorsal nucleus; ; subiculum; ; medial geniculate nucleus; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; lateral geniculate nucleus; ; lateral septal nucleus; ; primary motor cortex; ; primary visual cortex; ; neural layer of retina;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein C-terminus binding; metal ion binding; phosphatidylinositol-4,5-bisphosphate binding; calcium ion binding; clathrin binding; identical protein binding; calcium-dependent protein binding; phospholipid binding; SNARE binding; calmodulin binding; 1-phosphatidylinositol binding; phosphatidylserine binding; low-density lipoprotein particle receptor binding; syntaxin binding; protein binding; syntaxin-1 binding; calcium-dependent phospholipid binding; syntaxin-3 binding; protein heterodimerization activity; calcium ion sensor activity;
Cellular component	terminal bouton; SNARE complex; clathrin-sculpted glutamate transport vesicle membrane; intracellular organelle; cytoplasm; transport vesicle membrane; synapse; integral component of membrane; Golgi apparatus; cell junction; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane; presynaptic membrane; dense core granule; clathrin-sculpted monoamine transport vesicle membrane; neuron projection; chromaffin granule membrane; membrane; excitatory synapse; synaptic vesicle; secretory granule; clathrin-sculpted acetylcholine transport vesicle membrane; cytoplasmic vesicle; synaptic vesicle membrane; plasma membrane; integral component of synaptic vesicle membrane; axon; clathrin-coated vesicle membrane; neuron projection terminus; exocytic vesicle; hippocampal mossy fiber to CA3 synapse; glutamatergic synapse;
Biological process	detection of calcium ion; positive regulation of vesicle fusion; chemical synaptic transmission; synaptic vesicle exocytosis; positive regulation of calcium ion-dependent exocytosis; response to calcium ion; regulation of regulated secretory pathway; brain development; glutamate secretion; positive regulation of dendrite extension; positive regulation of synaptic transmission; regulation of synaptic transmission, glutamatergic; regulation of exocytosis; synaptic vesicle endocytosis; vesicle docking; cell differentiation; fast, calcium ion-dependent exocytosis of neurotransmitter; neurotransmitter secretion; cellular response to calcium ion; vesicle fusion; regulation of calcium ion-dependent exocytosis; calcium ion-regulated exocytosis of neurotransmitter; regulation of dopamine secretion; protein homooligomerization; protein heterooligomerization; membrane organization; vesicle-mediated transport; calcium-ion regulated exocytosis; calcium-dependent activation of synaptic vesicle fusion; spontaneous neurotransmitter secretion; synchronous neurotransmitter secretion; regulation of synaptic vesicle exocytosis; positive regulation of calcium ion-dependent exocytosis of neurotransmitter;
	Sources:Amigo / QuickGO
Orthologs
	6857
	20979
	ENSG00000067715
	ENSMUSG00000035864
	P21579
	P46096
	NM_001135805; NM_001135806; NM_001291901; NM_005639
NM_001252341; NM_001252342; NM_009306; NM_001358501; NM_001358502;
	NM_001358503; NM_001358504; NM_001358506
	NP_001129277; NP_001129278; NP_001278830; NP_005630
NP_001239270; NP_001239271; NP_033332; NP_001345430; NP_001345431;
	NP_001345432; NP_001345433; NP_001345435
	Wikidata
View/Edit Human	View/Edit Mouse

Synaptotagmin-1 is a protein that in humans is encoded by the SYT1 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000067715 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035864 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Perin MS, Johnston PA, Ozcelik T, Jahn R, Francke U, Südhof TC (Jan 1991). "Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans". The Journal of Biological Chemistry. 266 (1): 615–22. doi:10.1016/S0021-9258(18)52479-0. PMID 1840599.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000067715 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035864 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1840599-5] Perin MS, Johnston PA, Ozcelik T, Jahn R, Francke U, Südhof TC (Jan 1991). "Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans". The Journal of Biological Chemistry. 266 (1): 615–22. doi:10.1016/S0021-9258(18)52479-0. PMID 1840599.

SYT1 information

and 25 Related for: SYT1 information

SYT1

Synaptotagmin

FGF1

Annexin A5

SNARE protein

Inositol trisphosphate

Calbindin

Calmodulin

S100 protein

Calsequestrin

Calcium signaling

Annexin

Phospholamban

Annexin A1

Troponin C

Ryanodine receptor

Calreticulin

Calpain

Osteocalcin

Calretinin

FBLN5

S100G

Annexin A2

Calnexin

Regucalcin