voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels
Cellular component
vesicle
cytosol
endosome
membrane
late endosome membrane
melanosome
ruffle
plasma membrane
lipid droplet
myelin sheath adaxonal region
Schmidt-Lanterman incisure
PCSK9-AnxA2 complex
macropinosome
basement membrane
cell surface
lysosomal membrane
basolateral plasma membrane
cell cortex
midbody
early endosome
perinuclear region of cytoplasm
sarcolemma
extrinsic component of plasma membrane
extracellular exosome
nucleus
extracellular space
azurophil granule lumen
cytoplasm
membrane raft
extracellular matrix
extracellular region
protein-containing complex
collagen-containing extracellular matrix
Biological process
negative regulation of low-density lipoprotein particle receptor catabolic process
positive regulation of protein phosphorylation
protein heterotetramerization
fibrinolysis
body fluid secretion
collagen fibril organization
positive regulation of fibroblast proliferation
response to thyroid hormone
positive regulation of binding
positive regulation of vesicle fusion
membrane raft assembly
angiogenesis
vesicle budding from membrane
osteoclast development
cell-cell adhesion
negative regulation of catalytic activity
positive regulation of receptor recycling
neutrophil degranulation
positive regulation of low-density lipoprotein particle clearance
positive regulation of low-density lipoprotein particle receptor binding
positive regulation of low-density lipoprotein receptor activity
positive regulation of receptor-mediated endocytosis involved in cholesterol transport
negative regulation of formation of structure involved in a symbiotic process
positive regulation of vacuole organization
interleukin-12-mediated signaling pathway
protein localization to plasma membrane
growth plate cartilage development
regulation of plasminogen activation
biomineral tissue development
positive regulation of chondrocyte differentiation
positive regulation by host of viral process
regulation of cytosolic calcium ion concentration
positive regulation of calcium ion transport
endocardial cell differentiation
calcium ion transmembrane transport
positive regulation of viral life cycle
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
302
12306
Ensembl
ENSG00000182718
ENSMUSG00000032231
UniProt
P07355
P07356
RefSeq (mRNA)
NM_001002857 NM_001002858 NM_001136015 NM_004039
NM_007585
RefSeq (protein)
NP_001002857 NP_001002858 NP_001129487 NP_004030
NP_031611
Location (UCSC)
Chr 15: 60.35 – 60.4 Mb
Chr 9: 69.36 – 69.4 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Annexin A2 also known as annexin II is a protein that in humans is encoded by the ANXA2 gene.[5]
Annexin 2 is involved in diverse cellular processes such as cell motility (especially that of the epithelial cells), linkage of membrane-associated protein complexes to the actin cytoskeleton, endocytosis, fibrinolysis, ion channel formation, and cell matrix interactions.
It is a calcium-dependent phospholipid-binding protein whose function is to help organize exocytosis of intracellular proteins to the extracellular domain. Annexin II is a pleiotropic protein meaning that its function is dependent on place and time in the body.
^ abcGRCh38: Ensembl release 89: ENSG00000182718 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032231 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Takahashi S, Reddy SV, Chirgwin JM, Devlin R, Haipek C, Anderson J, Roodman GD (November 1994). "Cloning and identification of annexin II as an autocrine/paracrine factor that increases osteoclast formation and bone resorption". The Journal of Biological Chemistry. 269 (46): 28696–28701. doi:10.1016/S0021-9258(19)61961-7. PMID 7961821.
AnnexinA2 also known as annexin II is a protein that in humans is encoded by the ANXA2 gene. Annexin 2 is involved in diverse cellular processes such...
and fungi). In humans, the annexins are found inside the cell. However some annexins (Annexin A1, AnnexinA2, and Annexin A5) can be secreted from the...
receptor AnnexinA2, a protein Apolipoprotein A-II, a protein Phospholipase A2, an enzyme Prokaryotic phospholipase A2, an enzyme Hemoglobin A2, a protein...
Annexin A5 (or annexin V) is a cellular protein in the annexin group. In flow cytometry, annexin V is commonly used to detect apoptotic cells by its ability...
effects is to increase the synthesis and function of annexin A1. Annexin A1 both suppresses phospholipase A2, thereby blocking eicosanoid production, and inhibits...
detection in vivo. Specifically, HPV16 entry into Langerhans cells via the annexinA2/S100A10 heterotetramer results in suppressive signaling and lack of Langerhans...
in hepatocytes; it blocks aminopeptidase N and interrupts a caveolin 1–annexinA2 complex involved in trafficking cholesterol. Within 4–12 hours of the...
action contributes to the ability of berberine to lower serum cholesterol. AnnexinA2, an endogenous protein, is a natural inhibitor of PCSK9 activity. GRCh38:...
associates with putative receptors such as alpha integrins, laminins, and annexinA2 leading to entry of the virions into basal epithelial cells through clathrin-mediated...
Annexin A4 is a protein that in humans is encoded by the ANXA4 gene. Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid...
TCP protein domain Topoisomerase PCNA has been shown to interact with: AnnexinA2 CAF-1 CDC25C CHTF18 Cyclin D1 Cyclin O Cyclin-dependent kinase 4 Cyclin-dependent...
cytoskeleton-associated proteins, the small GTPases Rab5 and Rab7, AnnexinA2 (previously named Annexin II), the vacuolar ATPase, COP coat proteins, the N-ethylmaleimide...
Kwon M, MacLeod TJ, Zhang Y, Waisman DM (Jan 2005). "S100A10, annexinA2, and annexina2 heterotetramer as candidate plasminogen receptors". Frontiers...
Annexin A3 is a protein that in humans is encoded by the ANXA3 gene. It is abnormally expressed in fetuses of both IVF and ICSI, which may contribute...
be included in maternal profiling are endometrium-derived stathmin and annexinA2, whose down- and up-regulation, respectively, are associated with higher...
cargo. AnnexinA2, a membrane-bound protein, helps regulate vomocytosis and promote the fusing of vesicles to the plasma membranes. In annexinA2 deficient...
further research and development, Jaffee has hopes to make the protein, AnnexinA2, not as overworked to prevent the advancement of pancreatic cancer in...
in high-molecular weight complexes and interact with alpha-actinin and annexinA2". Biochimie. 84 (12): 1207–20. doi:10.1016/s0300-9084(02)00027-5. PMID 12628297...
RK, Bhattacharya SK (2011). "Cochlin induced TREK-1 co-expression and annexinA2 secretion: role in trabecular meshwork cell elongation and motility"....
regulated by MITF. CEACAM1 has been shown to interact with PTPN11 and AnnexinA2. Carcinoembryonic antigen Cluster of differentiation GRCh38: Ensembl release...
PMID 15159548. Knop M, Aareskjold E, Bode G, Gerke V (2005). "Rab3D and annexinA2 play a role in regulated secretion of vWF, but not tPA, from endothelial...
infection. Additionally, it has been shown that SLPI is able to bind the AnnexinA2/S100A10 heterotetramer (A2t), a co-factor HIV infection, on the surface...
Q, Weksler BB, Niesvizky R, Hajjar KA (July 2008). "Endothelial cell annexinA2 regulates polyubiquitination and degradation of its binding partner S100A10/p11"...
discovered the cell surface receptor for tissue plasminogen activator (annexinA2). Hajjar is an elected member of the Society for Pediatric Research, American...
protein , in some amphiphilic antimicrobial peptides , and in certain annexins . These proteins are usually described as peripheral as one of their conformational...
Annexin A8-like protein 2 is a protein that in humans is encoded by the ANXA8L2 gene. This gene encodes a member of the annexin family of evolutionarily...
Flower, Rod J. (2012-08-01). "Anti-inflammatory drugs, eicosanoids and the annexin A1/FPR2 anti-inflammatory system". Prostaglandins & Other Lipid Mediators...
They induce the lipocortin-1 (annexin-1) synthesis, which then binds to cell membranes preventing the phospholipase A2 from coming into contact with its...
Global Information
