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Molecular machinery driving vesicle fusion in neuromediator release. The core SNARE complex is formed by four α-helices contributed by synaptobrevin, syntaxin and SNAP-25, synaptotagmin serves as a calcium sensor and closely regulates the SNARE zipping.[1]
SNARE-fusion membrane complex proteins
Identifiers
Symbol
SNARE
InterPro
IPR010989
SCOP2
1kil / SCOPe / SUPFAM
TCDB
1.F.1
OPM superfamily
197
OPM protein
3hd7
Membranome
198
SNARE proteins – "SNAP REceptors" – are a large protein family consisting of at least 24 members in yeasts, more than 60 members in mammalian cells,[2][3] and some numbers in plants.[4] The primary role of SNARE proteins is to mediate the fusion of vesicles with the target membrane; this notably mediates exocytosis, but can also mediate the fusion of vesicles with membrane-bound compartments (such as a lysosome). The best studied SNAREs are those that mediate the release of synaptic vesicles containing neurotransmitters in neurons. These neuronal SNAREs are the targets of the neurotoxins responsible for botulism and tetanus produced by certain bacteria.
^Georgiev DD, Glazebrook JF (2007). "Subneuronal processing of information by solitary waves and stochastic processes". In Lyshevski SE (ed.). Nano and Molecular Electronics Handbook(PDF). Nano and Microengineering Series. CRC Press. pp. 17–1–17–41. doi:10.1201/9781315221670. ISBN 978-0-8493-8528-5.
^Burri L, Lithgow T (January 2004). "A complete set of SNAREs in yeast". Traffic. 5 (1): 45–52. doi:10.1046/j.1600-0854.2003.00151.x. PMID 14675424. S2CID 45480417.
^
Gerald K (2002). Cell and Molecular Biology (4th ed.). John Wiley & Sons.
SNAREproteins – "SNAP REceptors" – are a large protein family consisting of at least 24 members in yeasts, more than 60 members in mammalian cells, and...
Synaptosomal-Associated Protein, 25kDa (SNAP-25) is a Target Soluble NSF (N-ethylmaleimide-sensitive factor) Attachment Protein Receptor (t-SNARE) protein encoded by...
during intracellular transport and exocytosis. SNAPs interact with proteins of the SNARE complex and NSF to play a key role in recycling the components of...
universal secretory machinery in cells. Vesicle fusion may depend on SNAREproteins in the presence of increased intracellular calcium (Ca2+) concentration...
one of a small set of eukaryotic cytoplasmic neuronal proteins which binds to the SNAREprotein complex (SNAREpin) with a high affinity. These are called...
American silent film The Snare (1918 film), British silent film SNARE (protein), a family of proteins involved in vesicle fusion Snare technique (surgery)...
Synaptobrevin is one of the SNAREproteins involved in formation of the SNARE complexes. Out of four α-helices of the core SNARE complex one is contributed...
the CopII protein complexed with the snareprotein Bet1 (PDB: 1PCX). Conformation of the CopII protein that is complexed with the snareprotein Sed5 (PDB:...
Trafficking proteins are more complex. They include intrinsic membrane proteins, peripherally bound proteins, and proteins such as SNAREs. These proteins do not...
into the host cell cytoplasm where it cleaves the host protein SNAP-25, a member of the SNAREprotein family, which is responsible for fusion. The cleaved...
membrane integrated Q-SNAREproteins participating in exocytosis. Syntaxins possess a single C-terminal transmembrane domain, a SNARE domain (known as H3)...
Soluble NSF attachment protein, a family of proteins involved in vesicle membrane binding Proteins in the SNAP-receptor (SNAREprotein) family, including:...
use entirely different classes of fusion proteins, the best studied of which are the SNAREs. SNAREproteins are used to direct all vesicular intracellular...
immune cells secretion. In neurons and endocrine cells, the SNARE-proteins and SM-proteins catalyze the fusion by forming a complex that brings the two...
Freialdenhoven A, Somerville SC, Schulze-Lefert P (October 2003). "SNARE-protein-mediated disease resistance at the plant cell wall". Nature. 425 (6961):...
gradient. The calcium ions binds to the synaptotagmin 1 sub-unit of the SNAREprotein attached to the arginine-vasopressin (AVP) containing vesicle membrane...
with the presynaptic neuron's cell membrane in a process mediated by SNAREproteins. Fusion results in the emptying of the vesicle's contents of 7000–10...
t-SNAREs homolog 1A is a protein that in humans is encoded by the VTI1A gene. The protein encoded by the VTI1A gene is a vesicular-SNARE (v-SNARE) protein...
membranes. Rab proteins are key in targeting the membrane; SNAP and SNAREproteins are key in the fusion event. Initial glycosylation as assembly continues...
Synaptobrevin homolog YKT6 is a protein that in humans is encoded by the YKT6 gene. This gene product is one of the SNARE recognition molecules implicated...
of the vesicles contents mediated by proteins such as SNAREproteins. SNAREs are small, tail-anchored proteins which are often post-translationally inserted...
Shimomura H (Aug 2003). "Intracellular localisation of SNAREproteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane". Archives...
Syntaxin-10 (STX10) is a SNAREprotein that is encoded by the STX10 gene. This protein is found in most vertebrates (including humans) but is noticeably...
of SNAREproteins in the Golgi which would otherwise be bound to coat protein-coated vesicles and removed with the vesicles once they bud off. SNARE proteins...
types of SNAREproteins, v-SNARE's which are located on vesicle membranes, and t-SNARE's that are located on target membranes. SNAP29 is a t-SNARE, and as...
transient fusion of secretory vesicle membrane at a porosome, base via SNAREproteins, results in the formation of a fusion pore or continuity for the release...
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